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    Prkag2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit [ Mus musculus (house mouse) ]

    Gene ID: 108099, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prkag2provided by MGI
    Official Full Name
    protein kinase, AMP-activated, gamma 2 non-catalytic subunitprovided by MGI
    Primary source
    MGI:MGI:1336153
    See related
    Ensembl:ENSMUSG00000028944 AllianceGenome:MGI:1336153
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AAKG; WPWS; AAKG2; H91620p; 2410051C13Rik
    Summary
    Predicted to enable adenyl ribonucleotide binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to contribute to AMP-activated protein kinase activity. Predicted to be involved in several processes, including positive regulation of gluconeogenesis; regulation of carbon utilization; and regulation of phosphate metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; heart and pericardium; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 21.5), testis adult (RPKM 20.9) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Prkag2 in Genome Data Viewer
    Location:
    5 A3; 5 11.93 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (25067733..25311576, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24862735..25106282, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12648 Neighboring gene STARR-seq mESC enhancer starr_12649 Neighboring gene predicted gene, 33591 Neighboring gene crystallin, gamma N Neighboring gene STARR-positive B cell enhancer ABC_E666 Neighboring gene STARR-seq mESC enhancer starr_12651 Neighboring gene Ras homolog enriched in brain Neighboring gene protein kinase, AMP-activated, gamma 2 non-catalytic subunit, opposite strand 1 Neighboring gene predicted gene, 52767 Neighboring gene RIKEN cDNA 1500035N22 gene Neighboring gene STARR-seq mESC enhancer starr_12654 Neighboring gene RIKEN cDNA 2900005J15 gene Neighboring gene predicted gene, 42232 Neighboring gene predicted gene, 57732 Neighboring gene STARR-seq mESC enhancer starr_12657 Neighboring gene complement component 1, q subcomponent binding protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_12659 Neighboring gene predicted gene, 33836

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables AMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables AMP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to AMP-activated protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables AMP-activated protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cAMP-dependent protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cAMP-dependent protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cAMP-dependent protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphorylase kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphorylase kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to nutrient levels ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of carbon utilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nucleotide-activated protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nucleotide-activated protein kinase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    5'-AMP-activated protein kinase subunit gamma-2
    Names
    AMPK gamma-2 chain
    AMPK subunit gamma-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170555.1NP_001164026.1  5'-AMP-activated protein kinase subunit gamma-2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a large portion of the 5' coding region, and contains an alternate in-frame splice site compared to variant 1. It initiates translation at a downstream start codon. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC125270, AK032238, BQ572978, BU707674, BY128345
      UniProtKB/TrEMBL
      Q8BM63
      Conserved Domains (2) summary
      cd04618
      Location:27164
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:190313
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
    2. NM_001170556.1NP_001164027.1  5'-AMP-activated protein kinase subunit gamma-2 isoform 3

      See identical proteins and their annotated locations for NP_001164027.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks a large portion of the 5' coding region compared to variant 1. It initiates translation at a downstream start codon. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC125270, AK032238, AY348864, BY128345
      Consensus CDS
      CCDS51437.1
      UniProtKB/TrEMBL
      Q3TMN8, Q8BM63
      Related
      ENSMUSP00000110626.2, ENSMUST00000114975.8
      Conserved Domains (2) summary
      cd04618
      Location:26163
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:189312
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
    3. NM_001310480.1NP_001297409.1  5'-AMP-activated protein kinase subunit gamma-2 isoform 4

      See identical proteins and their annotated locations for NP_001297409.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains an alternate in-frame splice site compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC116151, AC125270, AK032238
      Consensus CDS
      CCDS80231.1
      UniProtKB/TrEMBL
      Q8BIQ9
      Related
      ENSMUSP00000075651.6, ENSMUST00000076306.12
      Conserved Domains (3) summary
      COG0517
      Location:309425
      CBS; CBS domain [Signal transduction mechanisms]
      cd04618
      Location:152281
      CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
      cd04641
      Location:308427
      CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    4. NM_145401.2NP_663376.2  5'-AMP-activated protein kinase subunit gamma-2 isoform 1

      See identical proteins and their annotated locations for NP_663376.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC116151, AC125270
      Consensus CDS
      CCDS19130.1
      UniProtKB/Swiss-Prot
      E9QK80, Q6V7V5, Q91WG5
      UniProtKB/TrEMBL
      Q3U4D5
      Related
      ENSMUSP00000030784.8, ENSMUST00000030784.14
      Conserved Domains (3) summary
      COG0517
      Location:432548
      CBS; CBS domain [Signal transduction mechanisms]
      cd04618
      Location:275404
      CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
      cd04641
      Location:431550
      CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      25067733..25311576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164724.1XP_036020617.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X5

      UniProtKB/TrEMBL
      Q3U4D5
      Conserved Domains (3) summary
      cd02205
      Location:274346
      CBS_pair_SF; CBS repeat [structural motif]
      cd04641
      Location:353476
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
      cl15354
      Location:266391
      CBS_pair_SF; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily
    2. XM_017320595.3XP_017176084.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X4

      UniProtKB/TrEMBL
      Q3U4D5
      Conserved Domains (3) summary
      cd02205
      Location:275347
      CBS_pair_SF; CBS repeat [structural motif]
      cd04641
      Location:354477
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
      cl15354
      Location:267392
      CBS_pair_SF; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily
    3. XM_006535611.5XP_006535674.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X1

      UniProtKB/TrEMBL
      Q3U4D5
      Conserved Domains (2) summary
      cd04618
      Location:267404
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:430553
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
    4. XM_006535612.5XP_006535675.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X2

      UniProtKB/TrEMBL
      Q3U4D5
      Conserved Domains (2) summary
      cd04618
      Location:223360
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:386509
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
    5. XM_030254043.2XP_030109903.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X3

      UniProtKB/TrEMBL
      Q3U4D5
      Conserved Domains (2) summary
      cd04618
      Location:222359
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:385508
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
    6. XM_006535614.4XP_006535677.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X6

      Conserved Domains (2) summary
      cd04618
      Location:115252
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:278401
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
    7. XM_030254044.2XP_030109904.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X9

      UniProtKB/TrEMBL
      Q8BM63
      Conserved Domains (2) summary
      cd04618
      Location:8145
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:171294
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
    8. XM_011249740.2XP_011248042.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X8

      UniProtKB/TrEMBL
      Q8BM63
      Conserved Domains (2) summary
      cd04618
      Location:24161
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:187310
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
    9. XM_017320596.2XP_017176085.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X7

      UniProtKB/TrEMBL
      Q8BM63
      Conserved Domains (2) summary
      cd04618
      Location:25162
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:188311
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
    10. XM_030254045.1XP_030109905.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X9

      UniProtKB/TrEMBL
      Q8BM63
      Conserved Domains (2) summary
      cd04618
      Location:8145
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:171294
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

    RNA

    1. XR_004942419.1 RNA Sequence

    2. XR_004942418.1 RNA Sequence

    3. XR_880821.4 RNA Sequence

    4. XR_389738.5 RNA Sequence