U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Adam15 ADAM metallopeptidase domain 15 [ Mus musculus (house mouse) ]

    Gene ID: 11490, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adam15provided by MGI
    Official Full Name
    ADAM metallopeptidase domain 15provided by MGI
    Primary source
    MGI:MGI:1333882
    See related
    Ensembl:ENSMUSG00000028041 AllianceGenome:MGI:1333882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AD56; MDC15
    Summary
    This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is prominently expressed in vascular cells, the endocardium, hypertrophic cells in developing bone, and specific areas of hippocampus and cerebellum. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein have increased bone mass resulting from osteoblast proliferation, and exhibit reduced neovascularization in a mouse model for retinopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing. [provided by RefSeq, May 2016]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 62.5), colon adult (RPKM 58.6) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Adam15 in Genome Data Viewer
    Location:
    3 F1; 3 39.07 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89246947..89257589, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89339640..89350028, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08230 Neighboring gene predicted gene, 34118 Neighboring gene ephrin A4 Neighboring gene STARR-positive B cell enhancer ABC_E4553 Neighboring gene DC-STAMP domain containing 1 Neighboring gene DC-STAMP domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_08235 Neighboring gene zinc finger and BTB domain containing 7B Neighboring gene STARR-seq mESC enhancer starr_08237 Neighboring gene STARR-positive B cell enhancer ABC_E3446 Neighboring gene predicted gene 15417

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables immunoglobulin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables immunoglobulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cardiac epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to phorbol 13-acetate 12-myristate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to phorbol 13-acetate 12-myristate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in collagen catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immune response to tumor cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immune response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypobaric hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tissue regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 15
    Names
    a disintegrin and metallopeptidase domain 15 (metargidin)
    a disintegrin and metalloprotease domain 15 (metargidin)
    metalloprotease RGD disintegrin protein
    metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037722.4NP_001032811.2  disintegrin and metalloproteinase domain-containing protein 15 isoform a preproprotein

      See identical proteins and their annotated locations for NP_001032811.2

      Status: VALIDATED

      Source sequence(s)
      AC171273
      Consensus CDS
      CCDS17502.1
      UniProtKB/Swiss-Prot
      A4ZYV2, O88839, Q3TDN7, Q3U7C2, Q3UE21, Q8C7Z0, Q91VS9, Q9QYL2
      UniProtKB/TrEMBL
      Q3TD57
      Related
      ENSMUSP00000029676.6, ENSMUST00000029676.12
      Conserved Domains (5) summary
      smart00050
      Location:431504
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:509650
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:214412
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:214414
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:67155
      Pep_M12B_propep; Reprolysin family propeptide
    2. NM_001409479.1NP_001396408.1  disintegrin and metalloproteinase domain-containing protein 15 isoform c preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC171273
      UniProtKB/TrEMBL
      Q3TD57
    3. NM_001409480.1NP_001396409.1  disintegrin and metalloproteinase domain-containing protein 15 isoform d preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC171273
      UniProtKB/TrEMBL
      Q3TD57
    4. NM_001409481.1NP_001396410.1  disintegrin and metalloproteinase domain-containing protein 15 isoform e preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC171273
      UniProtKB/TrEMBL
      Q3TD57
    5. NM_001409482.1NP_001396411.1  disintegrin and metalloproteinase domain-containing protein 15 isoform f precursor

      Status: VALIDATED

      Source sequence(s)
      AC171273
      UniProtKB/TrEMBL
      Q3TD57
    6. NM_001409483.1NP_001396412.1  disintegrin and metalloproteinase domain-containing protein 15 isoform g precursor

      Status: VALIDATED

      Source sequence(s)
      AC171273
      UniProtKB/TrEMBL
      Q3TD57
      Related
      ENSMUSP00000103072.3, ENSMUST00000107448.9
    7. NM_001409484.1NP_001396413.1  disintegrin and metalloproteinase domain-containing protein 15 isoform h precursor

      Status: VALIDATED

      Source sequence(s)
      AC171273
      UniProtKB/TrEMBL
      Q3TD57
    8. NM_001409485.1NP_001396414.1  disintegrin and metalloproteinase domain-containing protein 15 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC171273
      UniProtKB/TrEMBL
      Q3TD57
    9. NM_001409486.1NP_001396415.1  disintegrin and metalloproteinase domain-containing protein 15 isoform j precursor

      Status: VALIDATED

      Source sequence(s)
      AC171273
      UniProtKB/TrEMBL
      Q3TD57
    10. NM_001409487.1NP_001396416.1  disintegrin and metalloproteinase domain-containing protein 15 isoform k precursor

      Status: VALIDATED

      Source sequence(s)
      AC171273
      UniProtKB/TrEMBL
      Q3TD57
    11. NM_001409488.1NP_001396417.1  disintegrin and metalloproteinase domain-containing protein 15 isoform m

      Status: VALIDATED

      Source sequence(s)
      AC171273
      UniProtKB/TrEMBL
      Q3TD57
    12. NM_001409489.1NP_001396418.1  disintegrin and metalloproteinase domain-containing protein 15 isoform l

      Status: VALIDATED

      Source sequence(s)
      AC171273
      UniProtKB/TrEMBL
      Q3TD57
    13. NM_009614.4NP_033744.1  disintegrin and metalloproteinase domain-containing protein 15 isoform b precursor

      See identical proteins and their annotated locations for NP_033744.1

      Status: VALIDATED

      Source sequence(s)
      AC171273
      Consensus CDS
      CCDS17503.1
      UniProtKB/TrEMBL
      Q3TD57
      Related
      ENSMUSP00000074167.7, ENSMUST00000074582.7
      Conserved Domains (5) summary
      smart00050
      Location:431504
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:509650
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:214412
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:214414
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:67155
      Pep_M12B_propep; Reprolysin family propeptide

    RNA

    1. NR_176854.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC171273
    2. NR_176855.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC171273

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89246947..89257589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_375479.5 RNA Sequence

    2. XR_375480.5 RNA Sequence