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    ELMO1 engulfment and cell motility 1 [ Homo sapiens (human) ]

    Gene ID: 9844, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ELMO1provided by HGNC
    Official Full Name
    engulfment and cell motility 1provided by HGNC
    Primary source
    HGNC:HGNC:16286
    See related
    Ensembl:ENSG00000155849 MIM:606420; AllianceGenome:HGNC:16286
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CED12; CED-12; ELMO-1
    Summary
    This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
    Expression
    Broad expression in brain (RPKM 17.7), thyroid (RPKM 16.1) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ELMO1 in Genome Data Viewer
    Location:
    7p14.2-p14.1
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (36852906..37449326, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (36993255..37589754, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (36892511..37488929, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:36655105-36655606 Neighboring gene acyloxyacyl hydrolase Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:36693505-36694049 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:36701053-36701595 Neighboring gene AOAH intronic transcript 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:36802118-36803317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25844 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:36894293-36894794 Neighboring gene NANOG hESC enhancer GRCh37_chr7:36908573-36909127 Neighboring gene uncharacterized LOC105375235 Neighboring gene nucleophosmin 1 pseudogene 18 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25847 Neighboring gene MPRA-validated peak6484 silencer Neighboring gene Sharpr-MPRA regulatory region 8653 Neighboring gene microRNA 1200 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:37052330-37053529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25849 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:37071299-37072498 Neighboring gene ELMO1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25851 Neighboring gene NANOG hESC enhancer GRCh37_chr7:37156919-37157420 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:37193283-37193902 Neighboring gene small nucleolar RNA U13 Neighboring gene ribosomal protein S17 pseudogene 13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25852 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:37243623-37244822 Neighboring gene origin-enriched sequence 8 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:37287752-37288372 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:37288373-37288992 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:37318405-37318906 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:37318907-37319406 Neighboring gene Sharpr-MPRA regulatory region 7000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:37392751-37393252 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:37393979-37395178 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:37415805-37417004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25858 Neighboring gene RNA, U6 small nuclear 565, pseudogene Neighboring gene uncharacterized LOC124900242 Neighboring gene ribosomal protein S10 pseudogene 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18103 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:37569874-37570374 Neighboring gene Sharpr-MPRA regulatory region 7218 Neighboring gene NECAP endocytosis associated 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25859 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:37745514-37745731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25861 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18106 Neighboring gene G protein-coupled receptor 141

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Association between ELMO1 gene polymorphisms and diabetic kidney disease: A systematic review and meta-analysis. Azarboo A, et al. PLoS One, 2024. PMID 38277369, Free PMC Article
    2. Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy. Shimazaki A, et al. Diabetes, 2005 Apr. PMID 15793258
    3. ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion. Jarzynka MJ, et al. Cancer Res, 2007 Aug 1. PMID 17671188, Free PMC Article
    4. Variants in intron 13 of the ELMO1 gene are associated with diabetic nephropathy in African Americans. Leak TS, et al. Ann Hum Genet, 2009 Mar. PMID 19183347, Free PMC Article
    5. Confirmation of genetic associations at ELMO1 in the GoKinD collection supports its role as a susceptibility gene in diabetic nephropathy. Pezzolesi MG, et al. Diabetes, 2009 Nov. PMID 19651817, Free PMC Article

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Acetylation of ELMO1 correlates with Rac1 activity and colorectal cancer progress.
      Title: Acetylation of ELMO1 correlates with Rac1 activity and colorectal cancer progress.
    2. The Potential Impact of MYH9 (rs3752462) and ELMO1 (rs741301) Genetic Variants on the Risk of Nephrotic Syndrome Incidence.
      Title: The Potential Impact of MYH9 (rs3752462) and ELMO1 (rs741301) Genetic Variants on the Risk of Nephrotic Syndrome Incidence.
    3. Association between ELMO1 gene polymorphisms and diabetic kidney disease: A systematic review and meta-analysis.
      Title: Association between ELMO1 gene polymorphisms and diabetic kidney disease: A systematic review and meta-analysis.
    4. Engulfment and cell motility protein 1 fosters reprogramming of tumor-associated macrophages in colorectal cancer.
      Title: Engulfment and cell motility protein 1 fosters reprogramming of tumor-associated macrophages in colorectal cancer.
    5. Engulfment and Cell Motility 1 (ELMO1) Regulates Tumor Cell Behavior and Predicts Prognosis in Colorectal Cancer.
      Title: Engulfment and Cell Motility 1 (ELMO1) Regulates Tumor Cell Behavior and Predicts Prognosis in Colorectal Cancer.
    6. Role of ELMO1 in inflammation and cancer-clinical implications.
      Title: Role of ELMO1 in inflammation and cancer-clinical implications.
    7. The single nucleotide polymorphism rs11643718 in SLC12A3 is associated with the development of diabetic kidney disease in Chinese people with type 2 diabetes.
      Title: The single nucleotide polymorphism rs11643718 in SLC12A3 is associated with the development of diabetic kidney disease in Chinese people with type 2 diabetes.
    8. TNF-alpha-mediated m(6)A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis.
      Title: TNF-α-mediated m(6)A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis.
    9. Engulfment and cell motility 1 (ELMO1) and apolipoprotein A1 (APOA1) as candidate genes for sickle cell nephropathy.
      Title: Engulfment and cell motility 1 (ELMO1) and apolipoprotein A1 (APOA1) as candidate genes for sickle cell nephropathy.
    10. Association of ELMO1 gene polymorphism and diabetic nephropathy among Egyptian patients with type 2 diabetes mellitus.
      Title: Association of ELMO1 gene polymorphism and diabetic nephropathy among Egyptian patients with type 2 diabetes mellitus.
    Submit: New GeneRIF Correction See all GeneRIFs (55)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.
    EBI GWAS Catalog
    A genome-wide association study of the Protein C anticoagulant pathway.
    EBI GWAS Catalog
    Genetic variants associated with breast size also influence breast cancer risk.
    EBI GWAS Catalog
    Genetic variations associated with diabetic nephropathy and type II diabetes in a Japanese population.
    EBI GWAS Catalog
    Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
    EBI GWAS Catalog
    Genome-wide association study of smoking behaviours in patients with COPD.
    EBI GWAS Catalog
    Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
    EBI GWAS Catalog
    Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
    EBI GWAS Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Interaction of HIV-1 Nef with a protein complex, which includes Rac2, DOCK2, and ELMO1, activates Rac activity in T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0281, MGC126406

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell motility IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phagocytosis, engulfment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of guanyl-nucleotide exchange factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of guanyl-nucleotide exchange factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    engulfment and cell motility protein 1
    Names
    ced-12 homolog 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039459.3 → NP_001034548.1  engulfment and cell motility protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001034548.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC007349, BC064635, BI600726
      Consensus CDS
      CCDS5450.1
      UniProtKB/Swiss-Prot
      Q92556
      Related
      ENSP00000379355.2, ENST00000396040.6
      Conserved Domains (1) summary
      cd13359
      Location:66 → 195
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain

    2. NM_001206480.2 → NP_001193409.1  engulfment and cell motility protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001193409.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AC007349, AF398885, AK314349, DA238090, DA312397
      Consensus CDS
      CCDS5449.1
      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5, B4DJV6
      Related
      ENSP00000394458.1, ENST00000448602.5
      Conserved Domains (3) summary
      cd13359
      Location:546 → 675
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:303 → 481
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 279
      DUF3361; Domain of unknown function (DUF3361)

    3. NM_001206482.2 → NP_001193411.1  engulfment and cell motility protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001193411.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AC007349, AK291784
      Consensus CDS
      CCDS5449.1
      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5, B4DJV6
      Related
      ENSP00000406952.1, ENST00000442504.5
      Conserved Domains (3) summary
      cd13359
      Location:546 → 675
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:303 → 481
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 279
      DUF3361; Domain of unknown function (DUF3361)

    4. NM_014800.11 → NP_055615.8  engulfment and cell motility protein 1 isoform 1

      See identical proteins and their annotated locations for NP_055615.8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 4 and 5 encode the same isoform.
      Source sequence(s)
      AC007349, AC078843, AL136787
      Consensus CDS
      CCDS5449.1
      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5, B4DJV6
      Related
      ENSP00000312185.4, ENST00000310758.9
      Conserved Domains (3) summary
      cd13359
      Location:546 → 675
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:303 → 481
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 279
      DUF3361; Domain of unknown function (DUF3361)

    5. NM_130442.4 → NP_569709.1  engulfment and cell motility protein 1 isoform 2

      See identical proteins and their annotated locations for NP_569709.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC007349, BC077074, DC366992
      UniProtKB/Swiss-Prot
      Q92556
      Related
      ENSP00000379360.3, ENST00000396045.7
      Conserved Domains (1) summary
      cd13359
      Location:66 → 195
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain

    RNA

    1. NR_038120.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate 5' exon structure and lacks an alternate internal exon compared to variant 1 and lacks an alternate internal exon compared to variant 2. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC007349, AK301151

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      36852906..37449326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515654.3 → XP_011513956.1  engulfment and cell motility protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011513956.1

      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5, B4DJV6
      Conserved Domains (3) summary
      cd13359
      Location:546 → 675
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:303 → 481
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 279
      DUF3361; Domain of unknown function (DUF3361)

    2. XM_005249919.4 → XP_005249976.1  engulfment and cell motility protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005249976.1

      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5, B4DJV6
      Conserved Domains (3) summary
      cd13359
      Location:546 → 675
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:303 → 481
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 279
      DUF3361; Domain of unknown function (DUF3361)

    3. XM_047421086.1 → XP_047277042.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5

    4. XM_047421087.1 → XP_047277043.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5

    5. XM_047421088.1 → XP_047277044.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5

    6. XM_024447008.2 → XP_024302776.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5, B4DJV6
      Conserved Domains (3) summary
      cd13359
      Location:546 → 675
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:303 → 481
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 279
      DUF3361; Domain of unknown function (DUF3361)

    7. XM_017012839.2 → XP_016868328.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5, B4DJV6
      Conserved Domains (3) summary
      cd13359
      Location:546 → 675
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:303 → 481
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 279
      DUF3361; Domain of unknown function (DUF3361)

    8. XM_006715805.2 → XP_006715868.1  engulfment and cell motility protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006715868.1

      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5, B4DJV6
      Conserved Domains (3) summary
      cd13359
      Location:546 → 675
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:303 → 481
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 279
      DUF3361; Domain of unknown function (DUF3361)

    9. XM_047421089.1 → XP_047277045.1  engulfment and cell motility protein 1 isoform X2

    10. XM_047421091.1 → XP_047277047.1  engulfment and cell motility protein 1 isoform X3

    11. XM_047421090.1 → XP_047277046.1  engulfment and cell motility protein 1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      36993255..37589754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359429.1 → XP_054215404.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5

    2. XM_054359427.1 → XP_054215402.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5

    3. XM_054359426.1 → XP_054215401.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5

    4. XM_054359430.1 → XP_054215405.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5

    5. XM_054359431.1 → XP_054215406.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5

    6. XM_054359425.1 → XP_054215400.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5

    7. XM_054359428.1 → XP_054215403.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5

    8. XM_054359424.1 → XP_054215399.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
      UniProtKB/TrEMBL
      A4D1X5

    9. XM_054359432.1 → XP_054215407.1  engulfment and cell motility protein 1 isoform X2

    10. XM_054359434.1 → XP_054215409.1  engulfment and cell motility protein 1 isoform X3

    11. XM_054359433.1 → XP_054215408.1  engulfment and cell motility protein 1 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92556.2 GenPept UniProtKB/Swiss-Prot:Q92556

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