NOP14 NOP14 nucleolar protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: NOP14provided by HGNC
Official Full Name: NOP14 nucleolar proteinprovided by HGNC
Primary source: HGNC:HGNC:16821
See related: Ensembl:ENSG00000087269 MIM:611526; AllianceGenome:HGNC:16821
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: UTP2; NOL14; C4orf9; RES425; RES4-25
Summary: This gene encodes a protein that plays a role in pre-18s rRNA processing and small ribosomal subunit assembly. The encoded protein may be involved in the regulation of pancreatic cancer cell proliferation and migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression: Ubiquitous expression in lymph node (RPKM 10.9), appendix (RPKM 9.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4p16.3

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (2937936..2963406, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (2936399..2962082, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (2939663..2965133, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NOP14-mediated ribosome biogenesis is required for mTORC2 activation and predicts rapamycin sensitivity.
Title: NOP14-mediated ribosome biogenesis is required for mTORC2 activation and predicts rapamycin sensitivity.
Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer.
Title: Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer.
NOP14 regulates the growth, migration, and invasion of colorectal cancer cells by modulating the NRIP1/GSK-3beta/beta-catenin signaling pathway.
Title: NOP14 regulates the growth, migration, and invasion of colorectal cancer cells by modulating the NRIP1/GSK-3β/β-catenin signaling pathway.
CCND1, DNMT3B and NOP14 were identified as direct targets of miR-502-5p.
Title: CCND1, NOP14 and DNMT3B are involved in miR-502-5p-mediated inhibition of cell migration and proliferation in bladder cancer.
we identified an identical homozygous NOP14 variant as a possible contributing factor for RPL in two Iranian families.
Title: A homozygous NOP14 variant is likely to cause recurrent pregnancy loss.
Targeting NOP14 allows for effective suppression of tumor invasion in a mutp53-dependent manner, implicating NOP14 inhibition as a potential approach for attenuating metastasis in p53-mutant tumors
Title: Pancreatic Cancer Progression Relies upon Mutant p53-Induced Oncogenic Signaling Mediated by NOP14.
NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/beta-catenin pathway.
Title: NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway.
our study provides new evidence for NOP14 in regulating PC cell proliferation and migration, and may provide new insights for clinical diagnosis and therapy.
Title: NOP14 promotes proliferation and metastasis of pancreatic cancer cells.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

D4S95 (e-PCR)
- UniSTS:147237

D11S2560 (e-PCR)
- UniSTS:37928

SHGC-67833 (e-PCR)
- UniSTS:64558

D8S2279 (e-PCR)
- UniSTS:473907

D15S1477 (e-PCR)
- UniSTS:474482

D4S95 (e-PCR)
- UniSTS:146852

A006Q42 (e-PCR)
- UniSTS:50860

D4S95 (e-PCR)
- UniSTS:147933

RH103975 (e-PCR)
- UniSTS:98300

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables snoRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISS Inferred from Sequence or Structural Similarity more info
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISS Inferred from Sequence or Structural Similarity more info
involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISS Inferred from Sequence or Structural Similarity more info
involved_in maturation of SSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISS Inferred from Sequence or Structural Similarity more info
involved_in rRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of 90S preribosome	ISS Inferred from Sequence or Structural Similarity more info
part_of Noc4p-Nop14p complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Noc4p-Nop14p complex	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	HDA more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nucleolar protein 14

Names: NOP14 nucleolar protein homolog; probable nucleolar complex protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291978.2 → NP_001278907.1 nucleolar protein 14 isoform 1

See identical proteins and their annotated locations for NP_001278907.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AK025692, AK292939

Consensus CDS

CCDS33945.1

UniProtKB/Swiss-Prot

D3DVR6, P78316, Q7LGI5, Q7Z6K0, Q8TBR6

UniProtKB/TrEMBL

A8KA74

Related

ENSP00000405068.2, ENST00000416614.7

Conserved Domains (2) summary

pfam04147
Location:20 → 846

Nop14; Nop14-like family

cl03951
Location:202 → 321

CDC37_N; Cdc37 N terminal kinase binding
NM_001291979.2 → NP_001278908.1 nucleolar protein 14 isoform 2

See identical proteins and their annotated locations for NP_001278908.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains multiple differences in the 3' coding region and differs in the 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK025692, AK292939, BC026035

Consensus CDS

CCDS77893.1

UniProtKB/TrEMBL

E9PFK5

Related

ENSP00000381146.4, ENST00000398071.4

Conserved Domains (2) summary

pfam04147
Location:20 → 776

Nop14; Nop14-like family

cl03951
Location:202 → 321

CDC37_N; Cdc37 N terminal kinase binding
NM_003703.3 → NP_003694.1 nucleolar protein 14 isoform 1

See identical proteins and their annotated locations for NP_003694.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 2. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AF040965, AK025692, AK292939

Consensus CDS

CCDS33945.1

UniProtKB/Swiss-Prot

D3DVR6, P78316, Q7LGI5, Q7Z6K0, Q8TBR6

UniProtKB/TrEMBL

A8KA74

Related

ENSP00000315674.6, ENST00000314262.10

Conserved Domains (2) summary

pfam04147
Location:20 → 846

Nop14; Nop14-like family

cl03951
Location:202 → 321

CDC37_N; Cdc37 N terminal kinase binding