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    Znrf4 zinc and ring finger 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301127, updated on 4-Jan-2025

    Summary

    Official Symbol
    Znrf4provided by RGD
    Official Full Name
    zinc and ring finger 4provided by RGD
    Primary source
    RGD:1563631
    See related
    EnsemblRapid:ENSRNOG00000048875 AllianceGenome:RGD:1563631
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of cell cycle; negative regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ZNRF4 (zinc and ring finger 4). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See Znrf4 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1440444..1441632, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1353308..1354496, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (10535340..10536528)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene lysine demethylase 4B Neighboring gene transfer RNA lysine (anticodon CUU) 11 Neighboring gene protein tyrosine phosphatase, receptor type, S Neighboring gene TINCR ubiquitin domain containing Neighboring gene TINCR ubiquitin domain containing

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase ZNRF4
    Names
    zinc/RING finger protein 4
    NP_001020049.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024878.1NP_001020049.1  E3 ubiquitin-protein ligase ZNRF4 precursor

      See identical proteins and their annotated locations for NP_001020049.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098025
      UniProtKB/TrEMBL
      M0R940, Q4V7C2
      Related
      ENSRNOP00000066001.1, ENSRNOT00000075408.3
      Conserved Domains (2) summary
      pfam13639
      Location:207252
      zf-RING_2; Ring finger domain
      cl10459
      Location:3193
      Peptidases_S8_S53; Peptidase domain in the S8 and S53 families

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      1440444..1441632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)