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    Ralgdsl3 ral guanine nucleotide dissociation stimulator like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300444, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ralgdsl3provided by RGD
    Official Full Name
    ral guanine nucleotide dissociation stimulator like 3provided by RGD
    Primary source
    RGD:1309756
    See related
    EnsemblRapid:ENSRNOG00000013027 AllianceGenome:RGD:1309756
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rgl3
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. Orthologous to human RGL3 (ral guanine nucleotide dissociation stimulator like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 84.2), Kidney (RPKM 48.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ralgdsl3 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28775187..28796765, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20500846..20520471, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22980727..23000881, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene SWIM-type zinc finger 7 associated protein 1 Neighboring gene erythropoietin receptor Neighboring gene uncharacterized LOC134480147 Neighboring gene outer dynein arm docking complex subunit 3 Neighboring gene PRKCSH beta subunit of glucosidase II

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras. Shao H, et al. J Biol Chem, 2000 Sep 1. PMID 10869344
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ral guanine nucleotide dissociation stimulator-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429149.1 → NP_001416078.1  ral guanine nucleotide dissociation stimulator-like 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    2. NM_001429151.1 → NP_001416080.1  ral guanine nucleotide dissociation stimulator-like 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6JNW8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      28775187..28796765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265062.1 → XP_063121132.1  ral guanine nucleotide dissociation stimulator-like 3 isoform X5

    2. XM_063265061.1 → XP_063121131.1  ral guanine nucleotide dissociation stimulator-like 3 isoform X4

      Related
      ENSRNOP00000101883.1, ENSRNOT00000017493.5

    3. XM_063265060.1 → XP_063121130.1  ral guanine nucleotide dissociation stimulator-like 3 isoform X3

    4. XM_063265059.1 → XP_063121129.1  ral guanine nucleotide dissociation stimulator-like 3 isoform X2

    5. XM_063265064.1 → XP_063121134.1  ral guanine nucleotide dissociation stimulator-like 3 isoform X7

    6. XM_063265063.1 → XP_063121133.1  ral guanine nucleotide dissociation stimulator-like 3 isoform X6

    7. XM_063265058.1 → XP_063121128.1  ral guanine nucleotide dissociation stimulator-like 3 isoform X1

    8. XM_063265065.1 → XP_063121135.1  ral guanine nucleotide dissociation stimulator-like 3 isoform X8

    RNA

    1. XR_010053939.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106805.1: Suppressed sequence

      Description
      NM_001106805.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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