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    Tmprss13 transmembrane serine protease 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300682, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Tmprss13provided by RGD
    Official Full Name
    transmembrane serine protease 13provided by RGD
    Primary source
    RGD:1310872
    See related
    EnsemblRapid:ENSRNOG00000016397 AllianceGenome:RGD:1310872
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310872
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within establishment of skin barrier. Predicted to be located in endomembrane system and membrane. Orthologous to human TMPRSS13 (transmembrane serine protease 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 51.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmprss13 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (54522069..54550673)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (45625759..45653943)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (49621568..49650863)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene interleukin 10 receptor subunit alpha Neighboring gene glutathione S-transferase pi 1, pseudogene 4 Neighboring gene uncharacterized LOC120094137 Neighboring gene FXYD domain-containing ion transport regulator 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TMPRSS13 deficiency impairs stratum corneum formation and epidermal barrier acquisition. Madsen DH, et al. Biochem J, 2014 Aug 1. PMID 24832573, Free PMC Article
    2. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of skin barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protease serine 13
    Names
    transmembrane protease, serine 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127528.2 → NP_001121000.1  transmembrane protease serine 13

      See identical proteins and their annotated locations for NP_001121000.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AUK0, B2RYJ5
      Related
      ENSRNOP00000021949.6, ENSRNOT00000021949.7
      Conserved Domains (5) summary
      smart00020
      Location:297 → 526
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:298 → 526
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00530
      Location:216 → 288
      SRCR; Scavenger receptor cysteine-rich domain
      pfam15494
      Location:203 → 292
      SRCR_2; Scavenger receptor cysteine-rich domain
      cl23807
      Location:1 → 69
      WWbp; WW-domain ligand protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      54522069..54550673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265112.1 → XP_063121182.1  transmembrane protease serine 13 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AUK0, F7FMG3
    Nucleotide Protein Strain
    Heading Accession and Version

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