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    Arhgap25 Rho GTPase activating protein 25 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500246, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Arhgap25provided by RGD
    Official Full Name
    Rho GTPase activating protein 25provided by RGD
    Primary source
    RGD:1562105
    See related
    EnsemblRapid:ENSRNOG00000009347 AllianceGenome:RGD:1562105
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562105
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in actin filament organization; negative regulation of small GTPase mediated signal transduction; and phagocytosis, engulfment. Predicted to be active in phagocytic cup. Orthologous to human ARHGAP25 (Rho GTPase activating protein 25). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Spleen (RPKM 159.7), Thymus (RPKM 86.5) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgap25 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (121454151..121532293, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (119896844..119974982, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (119249682..119327822, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene gastrokine 3 Neighboring gene bone morphogenetic protein 10 Neighboring gene prokineticin receptor 1 Neighboring gene uncharacterized LOC120102330 Neighboring gene aprataxin and PNKP like factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins. Schlam D, et al. Nat Commun, 2015 Oct 14. PMID 26465210, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phagocytosis, engulfment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in phagocytic cup IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic cup ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109247.1 → NP_001102717.1  rho GTPase-activating protein 25

      Status: PROVISIONAL

      Source sequence(s)
      CH473957
      UniProtKB/TrEMBL
      A0A8I6A5M6, A6IB08, D3ZGL1
      Related
      ENSRNOP00000012645.5, ENSRNOT00000012645.7
      Conserved Domains (3) summary
      cd04390
      Location:156 → 354
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13263
      Location:45 → 157
      PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:47 → 149
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      121454151..121532293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108163.2 → XP_038964091.1  rho GTPase-activating protein 25 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5M6
      Conserved Domains (3) summary
      COG1196
      Location:518 → 619
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd04390
      Location:130 → 328
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      cd13263
      Location:19 → 131
      PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain

    2. XM_063286534.1 → XP_063142604.1  rho GTPase-activating protein 25 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A5M6

    3. XM_006236839.5 → XP_006236901.1  rho GTPase-activating protein 25 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A5M6
      Conserved Domains (4) summary
      cd04390
      Location:74 → 272
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      pfam00169
      Location:6 → 67
      PH; PH domain
      pfam07989
      Location:490 → 561
      Cnn_1N; Centrosomin N-terminal motif 1
      cl17171
      Location:4 → 75
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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