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    Ptk6 protein tyrosine kinase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366275, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ptk6provided by RGD
    Official Full Name
    protein tyrosine kinase 6provided by RGD
    Primary source
    RGD:1309098
    See related
    EnsemblRapid:ENSRNOG00000012987 AllianceGenome:RGD:1309098
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity; non-membrane spanning protein tyrosine kinase activity; and signaling receptor binding activity. Predicted to be involved in several processes, including cellular response to retinoic acid; negative regulation of protein tyrosine kinase activity; and protein phosphorylation. Predicted to be located in cytosol; nuclear body; and ruffle. Predicted to be active in plasma membrane. Orthologous to human PTK6 (protein tyrosine kinase 6). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Liver (RPKM 21.2) and Lung (RPKM 1.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptk6 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188684633..188693224, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168307073..168315664, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176698305..176706896, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486215 Neighboring gene pancreatic progenitor cell differentiation and proliferation factor Neighboring gene src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites Neighboring gene uncharacterized LOC108350541 Neighboring gene fibronectin type III domain containing 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The intracellular tyrosine kinase Brk sensitizes non-transformed cells to inducers of apoptosis. Haegebarth A, et al. Cell Cycle, 2005 Sep. PMID 16082217
    2. Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition. Qiu H, et al. J Biol Chem, 2002 Sep 13. PMID 12121988
    3. Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain. Hong E, et al. J Biol Chem, 2004 Jul 9. PMID 15056653
    4. Structural basis of the auto-inhibition mechanism of nonreceptor tyrosine kinase PTK6. Ko S, et al. Biochem Biophys Res Commun, 2009 Jun 26. PMID 19401189
    5. Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine. Haegebarth A, et al. Mol Cell Biol, 2006 Jul. PMID 16782882, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Brk does not promote proliferation of non-transformed cells, but plays a positive role in the regulation of the apoptotic response to DNA-damage and stress
      Title: The intracellular tyrosine kinase Brk sensitizes non-transformed cells to inducers of apoptosis.
    2. Sam68 suppresses BRK-induced cell proliferation, and regulates intranuclear localization and cell cycle progression
      Title: Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intestinal epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein-tyrosine kinase 6
    Names
    PTK6 protein tyrosine kinase 6
    NP_001102438.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108968.1 → NP_001102438.1  protein-tyrosine kinase 6

      Status: PROVISIONAL

      Source sequence(s)
      CH474066
      UniProtKB/TrEMBL
      A6KM34, D3ZDS3
      Related
      ENSRNOP00000017337.4, ENSRNOT00000017337.6
      Conserved Domains (4) summary
      cd10358
      Location:75 → 174
      SH2_PTK6_Brk; Src homology 2 domain found in protein-tyrosine kinase-6 (PTK6) which is also known as breast tumor kinase (Brk)
      cd11847
      Location:12 → 69
      SH3_Brk; Src homology 3 domain of Brk (Breast tumor kinase) Protein Tyrosine Kinase (PTK), also called PTK6
      smart00221
      Location:192 → 441
      STYKc; Protein kinase; unclassified specificity
      cl21453
      Location:184 → 444
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      188684633..188693224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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