Dusp22 dual specificity phosphatase 22 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dusp22provided by RGD
Official Full Name: dual specificity phosphatase 22provided by RGD
Primary source: RGD:1307146
See related: EnsemblRapid:ENSRNOG00000056376 AllianceGenome:RGD:1307146
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phosphoprotein phosphatase activity; protein tyrosine kinase binding activity; and protein tyrosine kinase inhibitor activity. Predicted to be involved in several processes, including cellular response to epidermal growth factor stimulus; negative regulation of focal adhesion assembly; and positive regulation of JNK cascade. Predicted to act upstream of or within several processes, including negative regulation of T cell mediated immunity; negative regulation of T cell receptor signaling pathway; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and leading edge of lamellipodium. Predicted to be part of filamentous actin. Predicted to be active in cytosol and plasma membrane. Orthologous to human DUSP22 (dual specificity phosphatase 22). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 126.9), Heart (RPKM 98.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (33989637..34040021, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (33780980..33831241, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (34986589..35037297, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH143737 (e-PCR)
- UniSTS:232983

RH131606 (e-PCR)
- UniSTS:214889

MKPX (e-PCR)
- UniSTS:266142

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables non-membrane spanning protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine/serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell mediated immunity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
located_in leading edge of lamellipodium	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dual specificity protein phosphatase 22

NP_001101882.1

EC 3.1.3.16

EC 3.1.3.48

NP_001386177.1

EC 3.1.3.16

EC 3.1.3.48

XP_006253950.1

EC 3.1.3.16

EC 3.1.3.48

XP_017456091.2

EC 3.1.3.16

EC 3.1.3.48

XP_017456092.2

EC 3.1.3.16

EC 3.1.3.48

XP_038951812.1

EC 3.1.3.16

EC 3.1.3.48

XP_063132659.1

EC 3.1.3.16

EC 3.1.3.48

XP_063132660.1

EC 3.1.3.16

EC 3.1.3.48

XP_063132661.1

EC 3.1.3.16

EC 3.1.3.48

XP_063132662.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108412.2 → NP_001101882.1 dual specificity protein phosphatase 22 isoform 1

See identical proteins and their annotated locations for NP_001101882.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A6J7L5

Conserved Domains (1) summary

cd14581
Location:2 → 150

DUSP22; dual specificity protein phosphatase 22
NM_001399248.2 → NP_001386177.1 dual specificity protein phosphatase 22 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I6AGY7, A6J7L7

Related

ENSRNOP00000092639.1, ENSRNOT00000094585.2

Conserved Domains (1) summary

cd14581
Location:2 → 150

DUSP22; dual specificity protein phosphatase 22

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

33989637..34040021 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276590.1 → XP_063132660.1 dual specificity protein phosphatase 22 isoform X6
XM_063276591.1 → XP_063132661.1 dual specificity protein phosphatase 22 isoform X7
XM_006253888.4 → XP_006253950.1 dual specificity protein phosphatase 22 isoform X2

Conserved Domains (1) summary

cd00127
Location:1 → 136

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
XM_063276589.1 → XP_063132659.1 dual specificity protein phosphatase 22 isoform X4

Related

ENSRNOP00000071916.3, ENSRNOT00000090946.3
XM_039095884.2 → XP_038951812.1 dual specificity protein phosphatase 22 isoform X5

Conserved Domains (1) summary

cl28904
Location:13 → 152

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_017600602.3 → XP_017456091.2 dual specificity protein phosphatase 22 isoform X1

Conserved Domains (1) summary

cd14581
Location:13 → 156

DUSP22; dual specificity protein phosphatase 22
XM_017600603.3 → XP_017456092.2 dual specificity protein phosphatase 22 isoform X3

UniProtKB/TrEMBL

D3ZC16

Conserved Domains (1) summary

cd14581
Location:13 → 156

DUSP22; dual specificity protein phosphatase 22
XM_063276592.1 → XP_063132662.1 dual specificity protein phosphatase 22 isoform X7