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    Rec8 REC8 meiotic recombination protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290227, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rec8provided by RGD
    Official Full Name
    REC8 meiotic recombination proteinprovided by RGD
    Primary source
    RGD:1309376
    See related
    EnsemblRapid:ENSRNOG00000019503 AllianceGenome:RGD:1309376
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rec8L1
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in double-strand break repair and meiotic sister chromatid cohesion. Predicted to act upstream of or within several processes, including germ cell development; meiosis I; and seminiferous tubule development. Predicted to be located in kinetochore; lateral element; and male germ cell nucleus. Predicted to be part of meiotic cohesin complex. Orthologous to human REC8 (REC8 meiotic recombination protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 85.5), Spleen (RPKM 9.1) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rec8 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33079818..33087283)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29109862..29117327)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34296922..34304387)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene interferon regulatory factor 9 Neighboring gene small ribosomal subunit protein uS19-like Neighboring gene importin 4 Neighboring gene transmembrane 9 superfamily member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Meiotic cohesin REC8 marks the axial elements of rat synaptonemal complexes before cohesins SMC1beta and SMC3. Eijpe M, et al. J Cell Biol, 2003 Mar 3. PMID 12615909, Free PMC Article
    2. Shugoshin-2 is essential for the completion of meiosis but not for mitotic cell division in mice. Llano E, et al. Genes Dev, 2008 Sep 1. PMID 18765791, Free PMC Article
    3. Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells. Lee J, et al. Nat Cell Biol, 2008 Jan. PMID 18084284
    4. SYCP2 and SYCP3 are required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division. Kouznetsova A, et al. J Cell Sci, 2005 May 15. PMID 15870106
    5. Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes. Ishiguro K, et al. Genes Dev, 2014 Mar 15. PMID 24589552, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homologous chromosome pairing at meiosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within male meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within meiotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within oocyte maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within seminiferous tubule development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within synaptonemal complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in condensed chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lateral element ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of meiotic cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of meiotic cohesin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptonemal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    meiotic recombination protein REC8 homolog
    Names
    REC8 homolog
    REC8-like 1
    cohesin Rec8p
    meiosis specific sister chromatid cohesion protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011916.2 → NP_001011916.1  meiotic recombination protein REC8 homolog

      See identical proteins and their annotated locations for NP_001011916.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q6AYJ4, Q6QQR2
      UniProtKB/TrEMBL
      A6KH22
      Related
      ENSRNOP00000026430.4, ENSRNOT00000026430.7
      Conserved Domains (2) summary
      pfam04824
      Location:538 → 592
      Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
      pfam04825
      Location:1 → 112
      Rad21_Rec8_N; N terminus of Rad21 / Rec8 like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      33079818..33087283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYJ4.1 GenPept UniProtKB/Swiss-Prot:Q6AYJ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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