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    Rnf114 ring finger protein 114 [ Mus musculus (house mouse) ]

    Gene ID: 81018, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf114provided by MGI
    Official Full Name
    ring finger protein 114provided by MGI
    Primary source
    MGI:MGI:1933159
    See related
    Ensembl:ENSMUSG00000006418 AllianceGenome:MGI:1933159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp228; Zfp313; Znf228; 1110008J21Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and plasma membrane. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human RNF114 (ring finger protein 114). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 45.5), large intestine adult (RPKM 37.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf114 in Genome Data Viewer
    Location:
    2 H3; 2 87.25 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (167334565..167358093)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (167492645..167516173)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5 Neighboring gene STARR-positive B cell enhancer ABC_E2061 Neighboring gene STARR-positive B cell enhancer ABC_E7887 Neighboring gene STARR-positive B cell enhancer ABC_E419 Neighboring gene STARR-positive B cell enhancer mm9_chr2:167200540-167200841 Neighboring gene STARR-positive B cell enhancer ABC_E4522 Neighboring gene STARR-seq mESC enhancer starr_06429 Neighboring gene STARR-positive B cell enhancer ABC_E7888 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 8 Neighboring gene STARR-seq mESC enhancer starr_06433 Neighboring gene STARR-positive B cell enhancer ABC_E9075 Neighboring gene spermatogenesis associated 2 Neighboring gene STARR-seq mESC enhancer starr_06435 Neighboring gene STARR-positive B cell enhancer mm9_chr2:167363409-167363710 Neighboring gene predicted gene 11474 Neighboring gene snail family zinc finger 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Maternal RNF114-mediated target substrate degradation regulates zygotic genome activation in mouse embryos. Zhou S, et al. Development, 2021 Jul 1. PMID 34104941
    2. Cloning and expression analysis of a novel mouse zinc finger protein gene Znf313 abundantly expressed in testis. Li N, et al. J Biochem Mol Biol, 2007 Mar 31. PMID 17394778
    3. The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal-to-zygotic transition. Yang Y, et al. EMBO Rep, 2017 Feb. PMID 28073917, Free PMC Article
    4. ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.). Han J, et al. Cell Death Differ, 2013 Aug. PMID 23645206, Free PMC Article
    5. Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114. Lin B, et al. Cytokine, 2017 Nov. PMID 28625874

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maternal RNF114-mediated target substrate degradation regulates zygotic genome activation in mouse embryos.
      Title: Maternal RNF114-mediated target substrate degradation regulates zygotic genome activation in mouse embryos.
    2. These data suggested the potential physiological function of RNF114 in inflammation and host antiviral responses, but demonstrate complexity in the regulation of innate immunity by ubiquitin ligases.
      Title: Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114.
    3. our study uncovers that RNF114-mediated ubiquitination and degradation of TAB1 activate the NF-kappaB pathway during MZT, and thus directly link maternal clearance to early embryo development.
      Title: The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal-to-zygotic transition.
    4. ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).
      Title: ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).
    5. Present data suggests that Znf313 gene might play a fundamental role in gene transcription and regulation and relates to spermatogenesis.
      Title: Cloning and expression analysis of a novel mouse zinc finger protein gene Znf313 abundantly expressed in testis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF114
    Names
    RING-type E3 ubiquitin transferase RNF114
    zinc finger protein 313
    NP_001347859.1
    NP_109668.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360930.1 → NP_001347859.1  E3 ubiquitin-protein ligase RNF114 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AF502145, AK148290
      Consensus CDS
      CCDS17101.1
      UniProtKB/Swiss-Prot
      Q3UFU8, Q8K5A2, Q9ET26
      Related
      ENSMUSP00000077197.7, ENSMUST00000078050.7
      Conserved Domains (2) summary
      pfam05605
      Location:141 → 201
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
      cd16540
      Location:28 → 69
      RING-HC_RNF114; RING finger, HC subclass, found in RING finger protein 114 (RNF114) and similar proteins

    2. NM_030743.6 → NP_109668.2  E3 ubiquitin-protein ligase RNF114 isoform 1

      See identical proteins and their annotated locations for NP_109668.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AL589870
      Consensus CDS
      CCDS17101.1
      UniProtKB/Swiss-Prot
      Q3UFU8, Q8K5A2, Q9ET26
      Related
      ENSMUSP00000104837.2, ENSMUST00000109214.8
      Conserved Domains (2) summary
      pfam05605
      Location:141 → 201
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
      cd16540
      Location:28 → 69
      RING-HC_RNF114; RING finger, HC subclass, found in RING finger protein 114 (RNF114) and similar proteins

    RNA

    1. NR_153838.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two 5' exons and an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF502145, AK148290, AK163062
      Related
      ENSMUST00000127939.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      167334565..167358093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001356496.1: Suppressed sequence

      Description
      NM_001356496.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ET26.2 GenPept UniProtKB/Swiss-Prot:Q9ET26

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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