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    Entrep1 endosomal transmembrane epsin interactor 1 [ Mus musculus (house mouse) ]

    Gene ID: 381217, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Entrep1provided by MGI
    Official Full Name
    endosomal transmembrane epsin interactor 1provided by MGI
    Primary source
    MGI:MGI:2685813
    See related
    Ensembl:ENSMUSG00000071604 AllianceGenome:MGI:2685813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm967; Fam189a2
    Summary
    Predicted to enable ubiquitin ligase activator activity. Predicted to be involved in CXCL12-activated CXCR4 signaling pathway and negative adaptation of signaling pathway. Predicted to be located in endosome membrane and plasma membrane. Is expressed in brain. Orthologous to human ENTREP1 (endosomal transmembrane epsin interactor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 35.1), genital fat pad adult (RPKM 20.0) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Entrep1 in Genome Data Viewer
    Location:
    19 B; 19 19.0 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (23950114..24008800, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (23972750..24031436, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene protein prenyltransferase alpha subunit repeat containing 1 Neighboring gene amyloid beta precursor protein binding family A member 1 Neighboring gene predicted gene, 34076 Neighboring gene STARR-seq mESC enhancer starr_45783 Neighboring gene predicted gene, 54056 Neighboring gene predicted gene, 41823

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genome-Scale CRISPRa Screen Identifies Novel Factors for Cellular Reprogramming. Yang J, et al. Stem Cell Reports, 2019 Apr 9. PMID 30905739, Free PMC Article
    2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    3. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin ligase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin ligase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in CXCL12-activated CXCR4 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CXCL12-activated CXCR4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative adaptation of signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative adaptation of signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    endosomal transmembrane epsin interactor 1
    Names
    family with sequence similarity 189, member A2
    protein FAM189A2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114174.1 → NP_001107646.1  endosomal transmembrane epsin interactor 1

      Status: VALIDATED

      Source sequence(s)
      AC140378, BC099492, BE994985, BQ032571, BY718707, CK624738, DV649334, DV650276
      Consensus CDS
      CCDS50408.1
      UniProtKB/Swiss-Prot
      Q4FZH1
      UniProtKB/TrEMBL
      E9QP68
      Related
      ENSMUSP00000093878.5, ENSMUST00000096164.6
      Conserved Domains (1) summary
      pfam04103
      Location:100 → 253
      CD20; CD20-like family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      23950114..24008800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527156.4 → XP_006527219.1  endosomal transmembrane epsin interactor 1 isoform X1

      Conserved Domains (1) summary
      pfam04103
      Location:100 → 234
      CD20; CD20-like family

    RNA

    1. XR_386486.4 RNA Sequence

    2. XR_001782594.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4FZH1.3 GenPept UniProtKB/Swiss-Prot:Q4FZH1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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