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    Aip aryl-hydrocarbon receptor-interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 11632, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aipprovided by MGI
    Official Full Name
    aryl-hydrocarbon receptor-interacting proteinprovided by MGI
    Primary source
    MGI:MGI:109622
    See related
    Ensembl:ENSMUSG00000024847 AllianceGenome:MGI:109622
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ara9; Xap2; Fkbp16; D19Bwg1412e
    Summary
    This gene encodes an Hsp90-associated protein that is localized to the cytoplasm. The encoded protein interacts with the aryl hydrocarbon receptor (AhR) and the tyrosine kinase receptor RET, inhibits AhR ubiquitination, and regulates the intracellular localization of AhR. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
    Expression
    Ubiquitous expression in ovary adult (RPKM 29.8), cerebellum adult (RPKM 28.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Aip in Genome Data Viewer
    Location:
    19 A; 19 3.82 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4163756..4177233, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4113756..4126559, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene calcium binding protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E84 Neighboring gene cyclin dependent kinase 2 associated protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:4103876-4104077 Neighboring gene phosphatidylinositol transfer protein, membrane-associated 1 Neighboring gene STARR-positive B cell enhancer ABC_E1965 Neighboring gene STARR-positive B cell enhancer ABC_E1966 Neighboring gene transmembrane protein 134 Neighboring gene STARR-positive B cell enhancer ABC_E5674 Neighboring gene calcium binding protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E11665 Neighboring gene G protein-coupled receptor 152

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality. Lin BC, et al. J Biol Chem, 2007 Dec 7. PMID 17916558
    2. A hypomorphic allele of aryl hydrocarbon receptor-associated protein-9 produces a phenocopy of the AHR-null mouse. Lin BC, et al. Mol Pharmacol, 2008 Nov. PMID 18669605, Free PMC Article
    3. In vivo siRNA delivery to the mouse hypothalamus shows a role of the co-chaperone XAP2 in regulating TRH transcription. Decherf S, et al. Methods Mol Biol, 2008. PMID 18679634
    4. Mice with inactivation of aryl hydrocarbon receptor-interacting protein (Aip) display complete penetrance of pituitary adenomas with aberrant ARNT expression. Raitila A, et al. Am J Pathol, 2010 Oct. PMID 20709796, Free PMC Article
    5. Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice. Schernthaner-Reiter MH, et al. Hum Mol Genet, 2020 Oct 10. PMID 32821937, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas.
      Title: RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas.
    2. Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice.
      Title: Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice.
    3. Results demonstrated that Aip inactivation promoted somatotroph tumorigenesis and overproduction of growth hormone probably through increased Stat3 activation.
      Title: Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line.
    4. Results provide novel evidence that AIP has an important role in the regulation of cAMP synthesis.
      Title: AIP inactivation leads to pituitary tumorigenesis through defective Gαi-cAMP signaling.
    5. XAP2 exerts a negative effect on ERalpha transcriptional activity and may thus prevent ERalpha-dependent events.
      Title: The immunophilin-like protein XAP2 is a negative regulator of estrogen signaling through interaction with estrogen receptor α.
    6. Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein
      Title: Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein.
    7. Mice with inactivation of aryl hydrocarbon receptor-interacting protein display complete penetrance of pituitary adenomas with aberrant ARNT expression.
      Title: Mice with inactivation of aryl hydrocarbon receptor-interacting protein (Aip) display complete penetrance of pituitary adenomas with aberrant ARNT expression.
    8. Data show that AIP is not required for the induction of the Cyp1a1 and Cyp1a2 genes.
      Title: The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes.
    9. expression level of ARA9 correlates with the frequency of a phenocopy of the Ahr-null allele supports the conclusion that the ARA9 protein is essential for AHR signaling during development
      Title: A hypomorphic allele of aryl hydrocarbon receptor-associated protein-9 produces a phenocopy of the AHR-null mouse.
    10. XAP2 affects triiodothyronine-transcriptional repression of the hypothalamic gene, throtropin releasing hormone.
      Title: In vivo siRNA delivery to the mouse hypothalamus shows a role of the co-chaperone XAP2 in regulating TRH transcription.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GAF domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GAF domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aryl hydrocarbon receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unfolded protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation by protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation by protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein kinase A signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within xenobiotic metabolic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of aryl hydrocarbon receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AH receptor-interacting protein
    NP_001263213.1
    NP_001396682.1
    NP_001396683.1
    NP_057875.1
    XP_036017297.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276284.2 → NP_001263213.1  AH receptor-interacting protein

      See identical proteins and their annotated locations for NP_001263213.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a portion of the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC109138
      Consensus CDS
      CCDS29415.1
      UniProtKB/Swiss-Prot
      O08915, Q3UJM2
      Related
      ENSMUSP00000025767.8, ENSMUST00000025767.14
      Conserved Domains (2) summary
      sd00006
      Location:181 → 225
      TPR; TPR repeat [structural motif]
      cl19519
      Location:29 → 90
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    2. NM_001409753.1 → NP_001396682.1  AH receptor-interacting protein

      Status: VALIDATED

      Source sequence(s)
      AC109138, FO082289
      UniProtKB/Swiss-Prot
      O08915, Q3UJM2

    3. NM_001409754.1 → NP_001396683.1  AH receptor-interacting protein

      Status: VALIDATED

      Source sequence(s)
      AC109138
      UniProtKB/Swiss-Prot
      O08915, Q3UJM2

    4. NM_016666.4 → NP_057875.1  AH receptor-interacting protein

      See identical proteins and their annotated locations for NP_057875.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC109138, FO082289
      Consensus CDS
      CCDS29415.1
      UniProtKB/Swiss-Prot
      O08915, Q3UJM2
      Related
      ENSMUSP00000113807.2, ENSMUST00000117831.8
      Conserved Domains (2) summary
      sd00006
      Location:181 → 225
      TPR; TPR repeat [structural motif]
      cl19519
      Location:29 → 90
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4163756..4177233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161404.1 → XP_036017297.1  AH receptor-interacting protein isoform X1

      UniProtKB/Swiss-Prot
      O08915, Q3UJM2
      Conserved Domains (2) summary
      sd00006
      Location:181 → 225
      TPR; TPR repeat [structural motif]
      cl19519
      Location:29 → 90
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08915.1 GenPept UniProtKB/Swiss-Prot:O08915

    Gene LinkOut

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