U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Tmem109 transmembrane protein 109 [ Mus musculus (house mouse) ]

    Gene ID: 68539, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmem109provided by MGI
    Official Full Name
    transmembrane protein 109provided by MGI
    Primary source
    MGI:MGI:1915789
    See related
    Ensembl:ENSMUSG00000034659 AllianceGenome:MGI:1915789
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110006I15Rik
    Summary
    Predicted to enable voltage-gated monoatomic cation channel activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Predicted to be located in nuclear membrane and sarcoplasmic reticulum membrane. Predicted to be part of monoatomic ion channel complex. Is expressed in central nervous system; early conceptus; retina; and secondary oocyte. Orthologous to human TMEM109 (transmembrane protein 109). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 107.7), lung adult (RPKM 86.9) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tmem109 in Genome Data Viewer
    Location:
    19 A; 19 7.29 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10848021..10859107, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10870657..10881743, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CD6 antigen Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10903953-10904062 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10904315-10904608 Neighboring gene STARR-seq mESC enhancer starr_45559 Neighboring gene STARR-positive B cell enhancer ABC_E5688 Neighboring gene solute carrier family 15, member 3 Neighboring gene transmembrane protein 132A Neighboring gene STARR-positive B cell enhancer ABC_E2520 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10956481-10956590 Neighboring gene STARR-positive B cell enhancer ABC_E8738 Neighboring gene pre-mRNA processing factor 19 Neighboring gene zona pellucida glycoprotein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables voltage-gated monoatomic cation channel activity  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum  
    part_of monoatomic ion channel complex  
    located_in nuclear membrane  
    located_in nuclear outer membrane  
    located_in sarcoplasmic reticulum membrane  

    General protein information

    Preferred Names
    voltage-gated monoatomic cation channel TMEM109
    Names
    mg23
    mitsugumin-23
    mitsugumin23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134142.1NP_598903.1  voltage-gated monoatomic cation channel TMEM109 precursor

      See identical proteins and their annotated locations for NP_598903.1

      Status: PROVISIONAL

      Source sequence(s)
      BC022997
      Consensus CDS
      CCDS29590.1
      UniProtKB/Swiss-Prot
      Q3UBX0, Q8R006
      UniProtKB/TrEMBL
      D3Z0I8
      Related
      ENSMUSP00000039529.9, ENSMUST00000038128.15
      Conserved Domains (1) summary
      pfam14965
      Location:57231
      BRI3BP; Negative regulator of p53/TP53

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      10848021..10859107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527317.1XP_006527380.1  voltage-gated monoatomic cation channel TMEM109 isoform X1

      See identical proteins and their annotated locations for XP_006527380.1

      UniProtKB/Swiss-Prot
      Q3UBX0, Q8R006
      UniProtKB/TrEMBL
      D3Z0I8
      Related
      ENSMUSP00000120261.2, ENSMUST00000133303.8
      Conserved Domains (1) summary
      pfam14965
      Location:57231
      BRI3BP; Negative regulator of p53/TP53
    External link. Please review our privacy policy.