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    PPP6R3 protein phosphatase 6 regulatory subunit 3 [ Homo sapiens (human) ]

    Gene ID: 55291, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PPP6R3provided by HGNC
    Official Full Name
    protein phosphatase 6 regulatory subunit 3provided by HGNC
    Primary source
    HGNC:HGNC:1173
    See related
    Ensembl:ENSG00000110075 MIM:610879; AllianceGenome:HGNC:1173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SAPL; PP6R3; SAPLa; SAPS3; SAP190; C11orf23
    Summary
    Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 14.0), testis (RPKM 11.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PPP6R3 in Genome Data Viewer
    Location:
    11q13.2
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (68460752..68615334)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (68465656..68620220)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (68228220..68382802)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68080045-68080920 Neighboring gene uncharacterized LOC124900302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68080921-68081795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68082507-68083006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68084075-68084742 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68095823-68096400 Neighboring gene uncharacterized LOC124902698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68099859-68100434 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68110204-68111055 Neighboring gene LDL receptor related protein 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68120602-68121235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68121869-68122501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5135 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68141212-68141935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5136 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:68154179-68154402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68164501-68165000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3671 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:68185667-68186590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68213843-68214446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68214447-68215051 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68215052-68215655 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68237400-68237900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68278329-68278907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68278908-68279485 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 2 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:68307752-68308457 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68310718-68311218 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68311219-68311719 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68351250-68351750 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:68370649-68370853 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68376961-68377462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68377463-68377962 Neighboring gene NANOG hESC enhancer GRCh37_chr11:68390073-68390603 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:68399697-68400286 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:68400287-68400875 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:68400876-68401464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68419596-68420268 Neighboring gene uncharacterized LOC107984343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68450731-68451406 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68452083-68452758 Neighboring gene Sharpr-MPRA regulatory region 1260 Neighboring gene NANOG hESC enhancer GRCh37_chr11:68462220-68462721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68474187-68474945 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68479758-68480258 Neighboring gene galanin and GMAP prepropeptide Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68518115-68519100 Neighboring gene testis expressed metallothionein like protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PPP6R3-USP6 amplification: Novel oncogenic mechanism in malignant nodular fasciitis. Guo R, et al. Genes Chromosomes Cancer, 2016 Aug. PMID 27113271
    2. Involvement of DPP9 in gene fusions in serous ovarian carcinoma. Smebye ML, et al. BMC Cancer, 2017 Sep 11. PMID 28893231, Free PMC Article
    3. Protein kinase CK2 phosphorylation of SAPS3 subunit increases PP6 phosphatase activity with Aurora A kinase. Heo J, et al. Biochem J, 2020 Jan 31. PMID 31904830
    4. The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13. Twells RC, et al. Genomics, 2001 Mar 15. PMID 11401438
    5. Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX. Douglas P, et al. Mol Cell Biol, 2010 Mar. PMID 20065038, Free PMC Article

    See all (144) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The substitution of Ala in nine putative phosphorylation sites in SAPS3 was required to prevent CK2 activation of the phosphatase. Different CK2 chemical inhibitors equally increased phosphorylation of endogenous AURKA in living cells, consistent with reduction in PP6 activity.
      Title: Protein kinase CK2 phosphorylation of SAPS3 subunit increases PP6 phosphatase activity with Aurora A kinase.
    2. Results from a study on gene expression variability markers in early-stage human embryos shows that PPP6R3 is a putative expression variability marker for the 3-day, 8-cell embryo stage.
      Title: Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
    3. we found a DPP9-PPP6R3 fusion transcript in one tumor showing a matching genomic 11;19-translocation. Another tumor had a rearrangement of DPP9 with PLIN3. Both rearrangements were associated with diminished expression of the 3' end of DPP9 corresponding to the breakpoints identified by RNA-seq.
      Title: Involvement of DPP9 in gene fusions in serous ovarian carcinoma.
    4. Molecular analyses revealed the presence and amplification of the novel PPPR6-USP6 gene fusion, which resulted in USP6 mRNA transcriptional upregulation. These findings further support the oncogenic role of the USP6 protease in mesenchymal neoplasia and expand the biologic potential of Nodular fasciitis
      Title: PPP6R3-USP6 amplification: Novel oncogenic mechanism in malignant nodular fasciitis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of protein phosphatase 6, regulatory subunit 3 (PPP6R3; C11orf23) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11058, FLJ43065, KIAA1558, MGC125711, MGC125712, DKFZp781E2374, DKFZp781O2362, DKFZp781E17107

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 6 regulatory subunit 3
    Names
    SAPS domain family, member 3
    sporulation-induced transcript 4-associated protein SAPL

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164160.2 → NP_001157632.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 4

      See identical proteins and their annotated locations for NP_001157632.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons, compared to variant 1. The resulting isoform (4) lacks two internal segments, compared to isoform 1. Variants 4, 24, and 39 all encode the same isoform (4).
      Source sequence(s)
      AB046778, BC007738, BP314824
      Consensus CDS
      CCDS53671.1
      UniProtKB/Swiss-Prot
      Q5H9R7
      Related
      ENSP00000377390.3, ENST00000393801.7
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    2. NM_001164161.2 → NP_001157633.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 6

      See identical proteins and their annotated locations for NP_001157633.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) includes an additional exon in the 5' UTR, lacks three alternate in-frame exons, and uses an alternate splice site resulting in a distinct 3' coding region, compared to variant 1. The resulting isoform (6) lacks three internal segments and has a distinct C-terminus, compared to isoform 1. Variants 6, 28, and 35 all encode the same isoform (6).
      Source sequence(s)
      AB046778, BC007738, BP314824, CR933658
      Consensus CDS
      CCDS53672.1
      UniProtKB/Swiss-Prot
      Q3B7I1, Q3I4Y0, Q3KR35, Q5H9R7, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3
      Related
      ENSP00000377389.2, ENST00000393800.7
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    3. NM_001164162.2 → NP_001157634.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 1

      See identical proteins and their annotated locations for NP_001157634.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), as well as variant 8, encodes isoform 1.
      Source sequence(s)
      BC007738, BC105933, BP314824, CR749815
      Consensus CDS
      CCDS53673.1
      UniProtKB/Swiss-Prot
      Q5H9R7
      Related
      ENSP00000433058.1, ENST00000524904.5
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    4. NM_001164163.2 → NP_001157635.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 2

      See identical proteins and their annotated locations for NP_001157635.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment near the C-terminus, compared to isoform 1. Variants 2 and 23 both encode the same isoform (2).
      Source sequence(s)
      AK315136, BC007738, BC107599
      Consensus CDS
      CCDS53674.1
      UniProtKB/Swiss-Prot
      Q5H9R7
      Related
      ENSP00000431415.1, ENST00000524845.5
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    5. NM_001164164.2 → NP_001157636.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 3

      See identical proteins and their annotated locations for NP_001157636.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (3) lacks two internal segments, compared to isoform 1.
      Source sequence(s)
      AF264780, BC007738, DB207620
      Consensus CDS
      CCDS53675.1
      UniProtKB/Swiss-Prot
      Q5H9R7
      Related
      ENSP00000437329.1, ENST00000529710.5
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 462
      SAPS; SIT4 phosphatase-associated protein

    6. NM_001352347.2 → NP_001339276.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096
      UniProtKB/TrEMBL
      H0YEN2
      Conserved Domains (1) summary
      pfam04499
      Location:1 → 288
      SAPS; SIT4 phosphatase-associated protein

    7. NM_001352348.2 → NP_001339277.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variant 1, encodes isoform 1.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Consensus CDS
      CCDS53673.1
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    8. NM_001352350.2 → NP_001339279.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 36 and 40, encodes isoform 8.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    9. NM_001352351.2 → NP_001339280.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096
      UniProtKB/TrEMBL
      E9PQP7
      Conserved Domains (1) summary
      pfam04499
      Location:37 → 422
      SAPS; SIT4 phosphatase-associated protein

    10. NM_001352352.2 → NP_001339281.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variant 31, encodes isoform 10.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    11. NM_001352353.2 → NP_001339282.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096
      UniProtKB/TrEMBL
      H0YEN2
      Conserved Domains (1) summary
      pfam04499
      Location:1 → 351
      SAPS; SIT4 phosphatase-associated protein

    12. NM_001352354.2 → NP_001339283.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 12

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variant 16, encodes isoform 12.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    13. NM_001352355.2 → NP_001339284.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096
      UniProtKB/TrEMBL
      E9PQP7
      Conserved Domains (1) summary
      pfam04499
      Location:37 → 422
      SAPS; SIT4 phosphatase-associated protein

    14. NM_001352356.2 → NP_001339285.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 12

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variant 14, encodes isoform 12.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    15. NM_001352357.2 → NP_001339286.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096
      UniProtKB/TrEMBL
      H0YEN2
      Related
      ENSP00000436209.1, ENST00000534190.5
      Conserved Domains (1) summary
      pfam04499
      Location:1 → 288
      SAPS; SIT4 phosphatase-associated protein

    16. NM_001352358.2 → NP_001339287.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 462
      SAPS; SIT4 phosphatase-associated protein

    17. NM_001352359.2 → NP_001339288.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096
      UniProtKB/TrEMBL
      E9PQP7
      Conserved Domains (1) summary
      pfam04499
      Location:37 → 422
      SAPS; SIT4 phosphatase-associated protein

    18. NM_001352360.2 → NP_001339289.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 17

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20), as well as variant 33, encodes isoform 17.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    19. NM_001352361.2 → NP_001339290.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096
      UniProtKB/TrEMBL
      E9PQP7
      Related
      ENSP00000434429.1, ENST00000534534.5
      Conserved Domains (1) summary
      pfam04499
      Location:37 → 422
      SAPS; SIT4 phosphatase-associated protein

    20. NM_001352362.2 → NP_001339291.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 19

      Status: VALIDATED

      Description
      Transcript Variant: This variant (22), as well as variant 25, encodes isoform 19.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    21. NM_001352363.2 → NP_001339292.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (23), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Consensus CDS
      CCDS53674.1
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    22. NM_001352364.2 → NP_001339293.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (24), as well as variants 4 and 39, encodes isoform 4.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Consensus CDS
      CCDS53671.1
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    23. NM_001352365.2 → NP_001339294.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 19

      Status: VALIDATED

      Description
      Transcript Variant: This variant (25), as well as variant 22, encodes isoform 19.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    24. NM_001352366.2 → NP_001339295.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 23

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    25. NM_001352368.2 → NP_001339297.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (28), as well as variants 6 and 35, encodes isoform 6.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Consensus CDS
      CCDS53672.1
      UniProtKB/Swiss-Prot
      Q3B7I1, Q3I4Y0, Q3KR35, Q5H9R7, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    26. NM_001352369.2 → NP_001339298.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096
      UniProtKB/TrEMBL
      H0YEN2
      Conserved Domains (1) summary
      pfam04499
      Location:1 → 288
      SAPS; SIT4 phosphatase-associated protein

    27. NM_001352370.2 → NP_001339299.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096
      UniProtKB/TrEMBL
      E9PQP7
      Conserved Domains (1) summary
      pfam04499
      Location:37 → 422
      SAPS; SIT4 phosphatase-associated protein

    28. NM_001352371.2 → NP_001339300.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (31), as well as variant 12, encodes isoform 10.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    29. NM_001352372.2 → NP_001339301.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 24

      Status: VALIDATED

      Description
      Transcript Variant: This variant (32), as well as variant 37, encodes isoform 24.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    30. NM_001352373.2 → NP_001339302.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 17

      Status: VALIDATED

      Description
      Transcript Variant: This variant (33), as well as variant 20, encodes isoform 17.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    31. NM_001352374.2 → NP_001339303.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 22

      Status: VALIDATED

      Description
      Transcript Variant: This variant (34), as well as variant 38, encodes isoform 22.
      Source sequence(s)
      AP000807, AP001788, AP003096
      UniProtKB/TrEMBL
      E9PQP7
      Conserved Domains (1) summary
      pfam04499
      Location:37 → 422
      SAPS; SIT4 phosphatase-associated protein

    32. NM_001352375.2 → NP_001339304.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (35), as well as variants 6 and 28, encodes isoform 6.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Consensus CDS
      CCDS53672.1
      UniProtKB/Swiss-Prot
      Q3B7I1, Q3I4Y0, Q3KR35, Q5H9R7, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    33. NM_001352376.2 → NP_001339305.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (36), as well as variants 10 and 40, encodes isoform 8.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    34. NM_001352377.2 → NP_001339306.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 24

      Status: VALIDATED

      Description
      Transcript Variant: This variant (37), as well as variant 32, encodes isoform 24.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    35. NM_001352378.2 → NP_001339307.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 22

      Status: VALIDATED

      Description
      Transcript Variant: This variant (38), as well as variant 34, encodes isoform 22.
      Source sequence(s)
      AP000807, AP001788, AP003096
      UniProtKB/TrEMBL
      E9PQP7
      Conserved Domains (1) summary
      pfam04499
      Location:37 → 422
      SAPS; SIT4 phosphatase-associated protein

    36. NM_001352379.2 → NP_001339308.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (39), as well as variants 4 and 24, encodes isoform 4.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Consensus CDS
      CCDS53671.1
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    37. NM_001352380.2 → NP_001339309.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (40), as well as variants 10 and 36, encodes isoform 8.
      Source sequence(s)
      AP000807, AP001788, AP003096
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    38. NM_001411030.1 → NP_001397959.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 25

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096
      Consensus CDS
      CCDS91521.1
      UniProtKB/TrEMBL
      E9PKF6

    39. NM_018312.5 → NP_060782.2  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 5

      See identical proteins and their annotated locations for NP_060782.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) includes an additional exon in the 5' UTR and lacks three alternate in-frame exons in the coding region, compared to variant 1. The resulting isoform (5) lacks three internal segments, compared to isoform 1.
      Source sequence(s)
      AF264779, BC007738, DB207620
      Consensus CDS
      CCDS8182.1
      Related
      ENSP00000265636.4, ENST00000265636.9
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 462
      SAPS; SIT4 phosphatase-associated protein

    RNA

    1. NR_147965.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096

    2. NR_147966.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096

    3. NR_147967.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096

    4. NR_147968.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096

    5. NR_147969.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096

    6. NR_147970.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096

    7. NR_147971.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000807, AP001788, AP003096

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      68460752..68615334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427204.1 → XP_047283160.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X3

      UniProtKB/Swiss-Prot
      Q3B7I1, Q3I4Y0, Q3KR35, Q5H9R7, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3

    2. XM_047427206.1 → XP_047283162.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

    3. XM_047427212.1 → XP_047283168.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

    4. XM_006718608.4 → XP_006718671.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    5. XM_006718612.4 → XP_006718675.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2

      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    6. XM_006718614.3 → XP_006718677.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

      See identical proteins and their annotated locations for XP_006718677.1

      UniProtKB/Swiss-Prot
      Q5H9R7
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    7. XM_047427209.1 → XP_047283165.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X5

    8. XM_017017969.2 → XP_016873458.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    9. XM_047427215.1 → XP_047283171.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

    10. XM_047427219.1 → XP_047283175.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X9

      UniProtKB/TrEMBL
      E9PKF6

    11. XM_006718621.3 → XP_006718684.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X10

      UniProtKB/TrEMBL
      H7BXH2
      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    12. XM_047427225.1 → XP_047283181.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X11

    13. XM_047427228.1 → XP_047283184.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X12

    14. XM_024448601.2 → XP_024304369.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X13

      Conserved Domains (1) summary
      pfam04499
      Location:128 → 462
      SAPS; SIT4 phosphatase-associated protein

    15. XM_006718624.3 → XP_006718687.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X15

      See identical proteins and their annotated locations for XP_006718687.1

      Conserved Domains (1) summary
      pfam04499
      Location:128 → 462
      SAPS; SIT4 phosphatase-associated protein

    16. XM_047427205.1 → XP_047283161.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X3

      UniProtKB/Swiss-Prot
      Q3B7I1, Q3I4Y0, Q3KR35, Q5H9R7, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3

    17. XM_047427207.1 → XP_047283163.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

    18. XM_047427213.1 → XP_047283169.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

    19. XM_047427208.1 → XP_047283164.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

    20. XM_047427211.1 → XP_047283167.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

    21. XM_047427216.1 → XP_047283172.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

    22. XM_047427218.1 → XP_047283174.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X8

    23. XM_047427223.1 → XP_047283179.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X10

      UniProtKB/TrEMBL
      H7BXH2

    24. XM_047427227.1 → XP_047283183.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X11

    25. XM_047427229.1 → XP_047283185.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X12

    26. XM_006718623.4 → XP_006718686.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X14

      See identical proteins and their annotated locations for XP_006718686.1

      Conserved Domains (1) summary
      pfam04499
      Location:128 → 462
      SAPS; SIT4 phosphatase-associated protein

    27. XM_047427214.1 → XP_047283170.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

    28. XM_047427202.1 → XP_047283158.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

    29. XM_047427203.1 → XP_047283159.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2

    30. XM_047427210.1 → XP_047283166.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X5

    31. XM_047427217.1 → XP_047283173.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

    32. XM_047427221.1 → XP_047283177.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X9

      UniProtKB/TrEMBL
      E9PKF6
      Related
      ENSP00000433565.1, ENST00000527403.6

    33. XM_047427224.1 → XP_047283180.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X10

      UniProtKB/TrEMBL
      H7BXH2
      Related
      ENSP00000265637.4, ENST00000265637.8

    34. XM_047427226.1 → XP_047283182.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X11

    35. XM_047427230.1 → XP_047283186.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X12

    36. XM_006718627.4 → XP_006718690.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X16

      Conserved Domains (1) summary
      pfam04499
      Location:128 → 513
      SAPS; SIT4 phosphatase-associated protein

    37. XM_047427232.1 → XP_047283188.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X16

    38. XM_047427231.1 → XP_047283187.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X16

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      68465656..68620220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369257.1 → XP_054225232.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X3

      UniProtKB/Swiss-Prot
      Q3B7I1, Q3I4Y0, Q3KR35, Q5H9R7, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3

    2. XM_054369260.1 → XP_054225235.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

    3. XM_054369266.1 → XP_054225241.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

    4. XM_054369253.1 → XP_054225228.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

    5. XM_054369255.1 → XP_054225230.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2

    6. XM_054369259.1 → XP_054225234.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

    7. XM_054369263.1 → XP_054225238.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X5

    8. XM_054369269.1 → XP_054225244.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

    9. XM_054369270.1 → XP_054225245.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

    10. XM_054369274.1 → XP_054225249.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X9

      UniProtKB/TrEMBL
      E9PKF6

    11. XM_054369276.1 → XP_054225251.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X10

      UniProtKB/TrEMBL
      H7BXH2

    12. XM_054369279.1 → XP_054225254.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X11

    13. XM_054369282.1 → XP_054225257.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X12

    14. XM_054369285.1 → XP_054225260.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X13

    15. XM_054369287.1 → XP_054225262.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X15

    16. XM_054369258.1 → XP_054225233.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X3

      UniProtKB/Swiss-Prot
      Q3B7I1, Q3I4Y0, Q3KR35, Q5H9R7, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3

    17. XM_054369261.1 → XP_054225236.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

    18. XM_054369267.1 → XP_054225242.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

    19. XM_054369262.1 → XP_054225237.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

    20. XM_054369265.1 → XP_054225240.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

    21. XM_054369271.1 → XP_054225246.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

    22. XM_054369273.1 → XP_054225248.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X8

    23. XM_054369277.1 → XP_054225252.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X10

      UniProtKB/TrEMBL
      H7BXH2

    24. XM_054369281.1 → XP_054225256.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X11

    25. XM_054369283.1 → XP_054225258.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X12

    26. XM_054369286.1 → XP_054225261.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X14

    27. XM_054369268.1 → XP_054225243.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

    28. XM_054369254.1 → XP_054225229.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

    29. XM_054369256.1 → XP_054225231.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2

    30. XM_054369264.1 → XP_054225239.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X5

    31. XM_054369272.1 → XP_054225247.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

    32. XM_054369275.1 → XP_054225250.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X9

      UniProtKB/TrEMBL
      E9PKF6

    33. XM_054369278.1 → XP_054225253.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X10

      UniProtKB/TrEMBL
      H7BXH2

    34. XM_054369280.1 → XP_054225255.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X11

    35. XM_054369284.1 → XP_054225259.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X12

    36. XM_054369288.1 → XP_054225263.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X16

    37. XM_054369290.1 → XP_054225265.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X16

    38. XM_054369289.1 → XP_054225264.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X16

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5H9R7.2 GenPept UniProtKB/Swiss-Prot:Q5H9R7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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