U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    SELENOT selenoprotein T [ Homo sapiens (human) ]

    Gene ID: 51714, updated on 10-Dec-2024

    Summary

    Official Symbol
    SELENOTprovided by HGNC
    Official Full Name
    selenoprotein Tprovided by HGNC
    Primary source
    HGNC:HGNC:18136
    See related
    Ensembl:ENSG00000198843 MIM:607912; AllianceGenome:HGNC:18136
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SELT
    Summary
    This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. Pseudogenes of this locus have been identified on chromosomes 9 and 5. [provided by RefSeq, Sep 2017]
    Expression
    Ubiquitous expression in brain (RPKM 31.9), adrenal (RPKM 30.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SELENOT in Genome Data Viewer
    Location:
    3q25.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (150603321..150630436)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (153354557..153381680)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (150321108..150348223)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:150263870-150265069 Neighboring gene stress associated endoplasmic reticulum protein 1 Neighboring gene eukaryotic translation initiation factor 2A Neighboring gene uncharacterized LOC124900547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20691 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:150321219-150321992 Neighboring gene SAP30 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 4372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20694 Neighboring gene glutamate rich 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20695 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20696 Neighboring gene ERICH6 antisense RNA 1 Neighboring gene small nuclear ribonucleoprotein polypeptide C pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables selenium binding PubMed 
    enables thioredoxin-disulfide reductase (NADPH) activity  
    enables thioredoxin-disulfide reductase (NADPH) activity  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis  
    involved_in cell redox homeostasis PubMed 
    involved_in cellular oxidant detoxification  
    involved_in glucose homeostasis  
    involved_in insulin secretion involved in cellular response to glucose stimulus  
    involved_in pancreas development  
    involved_in positive regulation of cytosolic calcium ion concentration  
    involved_in positive regulation of growth hormone secretion  
    involved_in response to glucose  
    involved_in selenocysteine incorporation PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  

    General protein information

    Preferred Names
    thioredoxin reductase-like selenoprotein T
    Names
    thioredoxin reductase-like enzyme
    NP_057359.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016275.5 → NP_057359.2  thioredoxin reductase-like selenoprotein T precursor

      See identical proteins and their annotated locations for NP_057359.2

      Status: REVIEWED

      Source sequence(s)
      AI686634, AK075006, BC026350, BC071699, DA997063
      Consensus CDS
      CCDS46936.1
      UniProtKB/Swiss-Prot
      O95904, P62341, Q8IY80, Q9CZ45, Q9NZJ3
      Related
      ENSP00000418910.1, ENST00000471696.6
      Conserved Domains (1) summary
      TIGR02174
      Location:41 → 179
      CXXU_selWTH; selT/selW/selH selenoprotein domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      150603321..150630436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      153354557..153381680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.