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    TRPT1 tRNA phosphotransferase 1 [ Homo sapiens (human) ]

    Gene ID: 83707, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TRPT1provided by HGNC
    Official Full Name
    tRNA phosphotransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:20316
    See related
    Ensembl:ENSG00000149743 MIM:610470; AllianceGenome:HGNC:20316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable tRNA 2'-phosphotransferase activity. Predicted to be involved in tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to act upstream of or within regulation of protein kinase activity. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart (RPKM 18.8), duodenum (RPKM 15.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRPT1 in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64223799..64226257, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64213745..64216203, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63991271..63993658, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3460 Neighboring gene uncharacterized LOC105369339 Neighboring gene MPRA-validated peak1294 silencer Neighboring gene uncharacterized LOC124902686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63948751-63949252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63949253-63949752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63951637-63952142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3461 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3462 Neighboring gene stress induced phosphoprotein 1 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr11:63972802-63973364 and GRCh37_chr11:63973365-63973927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4888 Neighboring gene FERM domain containing kindlin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4889 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:63992564-63993286 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63993887-63994406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63994407-63994924 Neighboring gene uncharacterized LOC124902687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3465 Neighboring gene nudix hydrolase 22 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3466 Neighboring gene DnaJ heat shock protein family (Hsp40) member C4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ADP-ribosylation of RNA in mammalian cells is mediated by TRPT1 and multiple PARPs. Weixler L, et al. Nucleic Acids Res, 2022 Sep 9. PMID 36018800, Free PMC Article
    2. A human homolog of the yeast gene encoding tRNA 2'-phosphotransferase: cloning, characterization and complementation analysis. Hu QD, et al. Cell Mol Life Sci, 2003 Aug. PMID 14504659, Free PMC Article
    3. Structural and biochemical insights into the molecular mechanism of TRPT1 for nucleic acid ADP-ribosylation. Yang X, et al. Nucleic Acids Res, 2023 Aug 11. PMID 37334830, Free PMC Article
    4. Genome-wide association study of the child behavior checklist dysregulation profile. Mick E, et al. J Am Acad Child Adolesc Psychiatry, 2011 Aug. PMID 21784300, Free PMC Article
    5. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural and biochemical insights into the molecular mechanism of TRPT1 for nucleic acid ADP-ribosylation.
      Title: Structural and biochemical insights into the molecular mechanism of TRPT1 for nucleic acid ADP-ribosylation.
    2. ADP-ribosylation of RNA in mammalian cells is mediated by TRPT1 and multiple PARPs.
      Title: ADP-ribosylation of RNA in mammalian cells is mediated by TRPT1 and multiple PARPs.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of the child behavior checklist dysregulation profile.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of tRNA phosphotransferase 1 (TRPT1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11134

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tRNA 2'-phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA splicing, via endonucleolytic cleavage and ligation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA 2'-phosphotransferase 1
    Names
    tRNA splicing 2' phosphotransferase 1
    NP_001028850.2
    NP_001153861.1
    NP_001153862.1
    NP_001153864.1
    NP_001153865.1
    NP_001317227.1
    NP_113660.1
    XP_005274402.1
    XP_005274403.1
    XP_005274404.1
    XP_006718770.1
    XP_016873889.1
    XP_024304476.1
    XP_024304477.1
    XP_047283635.1
    XP_047283636.1
    XP_047283637.1
    XP_047283638.1
    XP_054226108.1
    XP_054226109.1
    XP_054226110.1
    XP_054226111.1
    XP_054226112.1
    XP_054226113.1
    XP_054226114.1
    XP_054226115.1
    XP_054226116.1
    XP_054226117.1
    XP_054226118.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033678.4 → NP_001028850.2  tRNA 2'-phosphotransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_001028850.2

      Status: VALIDATED

      Source sequence(s)
      AP005668, AP006334
      Consensus CDS
      CCDS31595.1
      UniProtKB/Swiss-Prot
      A8MU17, A8MYC9, F5H2B2, Q86TN4, Q9BSB9
      Related
      ENSP00000314073.6, ENST00000317459.11
      Conserved Domains (1) summary
      pfam01885
      Location:26 → 203
      PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

    2. NM_001160389.2 → NP_001153861.1  tRNA 2'-phosphotransferase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AP005668, AP006334
      Consensus CDS
      CCDS53652.1
      UniProtKB/Swiss-Prot
      Q86TN4
      Related
      ENSP00000378050.2, ENST00000394546.6
      Conserved Domains (1) summary
      pfam01885
      Location:31 → 204
      PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

    3. NM_001160390.2 → NP_001153862.1  tRNA 2'-phosphotransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_001153862.1

      Status: VALIDATED

      Source sequence(s)
      AP005668, AP006334
      Consensus CDS
      CCDS31595.1
      UniProtKB/Swiss-Prot
      A8MU17, A8MYC9, F5H2B2, Q86TN4, Q9BSB9
      Conserved Domains (1) summary
      pfam01885
      Location:26 → 203
      PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

    4. NM_001160392.2 → NP_001153864.1  tRNA 2'-phosphotransferase 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AP005668, AP006334
      Consensus CDS
      CCDS53653.1
      UniProtKB/TrEMBL
      F5H8A0
      Related
      ENSP00000438683.1, ENST00000541278.5
      Conserved Domains (1) summary
      pfam01885
      Location:31 → 186
      PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

    5. NM_001160393.1 → NP_001153865.1  tRNA 2'-phosphotransferase 1 isoform 5

      See identical proteins and their annotated locations for NP_001153865.1

      Status: VALIDATED

      Source sequence(s)
      AY211494, BC005133, BM982538
      UniProtKB/Swiss-Prot
      Q86TN4
      Conserved Domains (1) summary
      pfam01885
      Location:31 → 203
      PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

    6. NM_001330298.2 → NP_001317227.1  tRNA 2'-phosphotransferase 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AP005668, AP006334
      Consensus CDS
      CCDS81579.1
      UniProtKB/TrEMBL
      F5H6B6
      Related
      ENSP00000437741.1, ENST00000546089.5

    7. NM_031472.4 → NP_113660.1  tRNA 2'-phosphotransferase 1 isoform 2

      See identical proteins and their annotated locations for NP_113660.1

      Status: VALIDATED

      Source sequence(s)
      AP005668, AP006334
      Consensus CDS
      CCDS44639.1
      Related
      ENSP00000378051.3, ENST00000394547.7
      Conserved Domains (1) summary
      pfam01885
      Location:1 → 154
      PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      64223799..64226257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448709.2 → XP_024304477.1  tRNA 2'-phosphotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A8MU17, A8MYC9, F5H2B2, Q86TN4, Q9BSB9
      Conserved Domains (1) summary
      pfam01885
      Location:26 → 203
      PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

    2. XM_047427679.1 → XP_047283635.1  tRNA 2'-phosphotransferase 1 isoform X3

      UniProtKB/TrEMBL
      F5H8A0

    3. XM_006718707.4 → XP_006718770.1  tRNA 2'-phosphotransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006718770.1

      Conserved Domains (1) summary
      pfam01885
      Location:31 → 203
      PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

    4. XM_024448708.2 → XP_024304476.1  tRNA 2'-phosphotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A8MU17, A8MYC9, F5H2B2, Q86TN4, Q9BSB9
      Conserved Domains (1) summary
      pfam01885
      Location:26 → 203
      PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

    5. XM_005274346.5 → XP_005274403.1  tRNA 2'-phosphotransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_005274403.1

      Conserved Domains (1) summary
      pfam01885
      Location:31 → 203
      PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

    6. XM_047427682.1 → XP_047283638.1  tRNA 2'-phosphotransferase 1 isoform X6

      UniProtKB/TrEMBL
      F5H1K3
      Related
      ENSP00000439586.1, ENST00000546133.5

    7. XM_047427681.1 → XP_047283637.1  tRNA 2'-phosphotransferase 1 isoform X5

    8. XM_017018400.2 → XP_016873889.1  tRNA 2'-phosphotransferase 1 isoform X4

      Conserved Domains (1) summary
      pfam01885
      Location:1 → 154
      PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

    9. XM_047427680.1 → XP_047283636.1  tRNA 2'-phosphotransferase 1 isoform X3

      UniProtKB/TrEMBL
      F5H8A0

    10. XM_005274347.5 → XP_005274404.1  tRNA 2'-phosphotransferase 1 isoform X4

      Conserved Domains (1) summary
      pfam01885
      Location:1 → 154
      PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

    11. XM_005274345.5 → XP_005274402.1  tRNA 2'-phosphotransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_005274402.1

      Conserved Domains (1) summary
      pfam01885
      Location:31 → 203
      PTS_2-RNA; RNA 2'-phosphotransferase, Tpt1 / KptA family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      64213745..64216203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370136.1 → XP_054226111.1  tRNA 2'-phosphotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A8MU17, A8MYC9, F5H2B2, Q86TN4, Q9BSB9

    2. XM_054370137.1 → XP_054226112.1  tRNA 2'-phosphotransferase 1 isoform X3

      UniProtKB/TrEMBL
      F5H8A0

    3. XM_054370135.1 → XP_054226110.1  tRNA 2'-phosphotransferase 1 isoform X1

    4. XM_054370143.1 → XP_054226118.1  tRNA 2'-phosphotransferase 1 isoform X6

      UniProtKB/TrEMBL
      F5H1K3

    5. XM_054370142.1 → XP_054226117.1  tRNA 2'-phosphotransferase 1 isoform X5

    6. XM_054370141.1 → XP_054226116.1  tRNA 2'-phosphotransferase 1 isoform X4

    7. XM_054370139.1 → XP_054226114.1  tRNA 2'-phosphotransferase 1 isoform X3

      UniProtKB/TrEMBL
      F5H8A0

    8. XM_054370140.1 → XP_054226115.1  tRNA 2'-phosphotransferase 1 isoform X4

    9. XM_054370138.1 → XP_054226113.1  tRNA 2'-phosphotransferase 1 isoform X1

    10. XM_054370134.1 → XP_054226109.1  tRNA 2'-phosphotransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A8MU17, A8MYC9, F5H2B2, Q86TN4, Q9BSB9

    11. XM_054370133.1 → XP_054226108.1  tRNA 2'-phosphotransferase 1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86TN4.2 GenPept UniProtKB/Swiss-Prot:Q86TN4

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