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    HDLBP high density lipoprotein binding protein [ Homo sapiens (human) ]

    Gene ID: 3069, updated on 10-Dec-2024

    Summary

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    Official Symbol
    HDLBPprovided by HGNC
    Official Full Name
    high density lipoprotein binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:4857
    See related
    Ensembl:ENSG00000115677 MIM:142695; AllianceGenome:HGNC:4857
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HBP; VGL; PRO2900
    Summary
    The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in testis (RPKM 89.6), thyroid (RPKM 63.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HDLBP in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (241227291..241315672, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (241726284..241814658, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242166706..242255087, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17414 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17415 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57723 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57727 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242079269-242079769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12529 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12530 Neighboring gene PAS domain containing serine/threonine kinase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12531 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242097726-242098226 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:242106157-242106656 Neighboring gene uncharacterized LOC105373971 Neighboring gene protein phosphatase 1 regulatory subunit 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242125644-242126166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242127362-242128046 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242128047-242128730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242129664-242130164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242130165-242130665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242152515-242153074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242155713-242156244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17420 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242163435-242164395 Neighboring gene uncharacterized LOC105376810 Neighboring gene anoctamin 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:242175313-242175524 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:242189957-242190163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12534 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:242220649-242221149 Neighboring gene HDLBP antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242248819-242249320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17424 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242255088-242255812 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242255813-242256537 Neighboring gene septin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12537 Neighboring gene uncharacterized LOC105373973 Neighboring gene Sharpr-MPRA regulatory region 5168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12538 Neighboring gene FERM, ARH/RhoGEF and pleckstrin domain protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242386413-242387062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242407765-242408327 Neighboring gene microRNA 3133

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression of a cellular high density lipoprotein-binding protein that is up-regulated by cholesterol loading of cells. McKnight GL, et al. J Biol Chem, 1992 Jun 15. PMID 1318310
    2. High-density lipoprotein-binding protein (HBP)/vigilin is expressed in human atherosclerotic lesions and colocalizes with apolipoprotein E. Chiu DS, et al. Arterioscler Thromb Vasc Biol, 1997 Nov. PMID 9409201
    3. Two additional 5' exons in the human Vigilin gene distinguish it from the chicken gene and provide the structural basis for differential routes of gene expression. Kügler S, et al. Eur J Biochem, 1996 Jun 1. PMID 8681952
    4. Characterization of a 95 kDa high affinity human high density lipoprotein-binding protein. Bocharov AV, et al. Biochemistry, 2001 Apr 10. PMID 11284697
    5. Multifaceted functions of RNA-binding protein vigilin in gene silencing, genome stability, and autism-related disorders. Mushtaq A, et al. J Biol Chem, 2023 Mar. PMID 36758804, Free PMC Article

    See all (188) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Multifaceted functions of RNA-binding protein vigilin in gene silencing, genome stability, and autism-related disorders.
      Title: Multifaceted functions of RNA-binding protein vigilin in gene silencing, genome stability, and autism-related disorders.
    2. HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.
      Title: HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.
    3. HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma.
      Title: HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma.
    4. The lipid transporter HDLBP promotes hepatocellular carcinoma metastasis through BRAF-dependent epithelial-mesenchymal transition.
      Title: The lipid transporter HDLBP promotes hepatocellular carcinoma metastasis through BRAF-dependent epithelial-mesenchymal transition.
    5. HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
      Title: HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
    6. TSC2 Interacts with HDLBP/Vigilin and Regulates Stress Granule Formation.
      Title: TSC2 Interacts with HDLBP/Vigilin and Regulates Stress Granule Formation.
    7. Our data reveal that vigilin is essential for maintenance of imprinting of IGF2 gene via functional interaction between KH1-7 domains of vigilin and zinc-finger domains of CTCF.
      Title: Vigilin interacts with CTCF and is involved in the maintenance of imprinting of IGF2 through a novel RNA-mediated mechanism.
    8. vigilin has been shown to bind over 700 mRNAs and has been associated with cancer progression and cardiovascular disease.
      Title: A jack of all trades: the RNA-binding protein vigilin.
    9. this study shows that vigilin (HDLBP) binds and negatively regulates MICB expression through its 5'UTR, and that vigilin downregulation in target cells leads to NK cell activation against said target cells
      Title: Vigilin Regulates the Expression of the Stress-Induced Ligand MICB by Interacting with Its 5' Untranslated Region.
    10. progressively upregulated vigilin may serve as a molecular risk marker for hepatocellular carcinoma development, and targeting vigilin may help to inhibit hepatocellular carcinoma cell growth, survival and migration.
      Title: Vigilin is overexpressed in hepatocellular carcinoma and is required for HCC cell proliferation and tumor growth.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated high density lipoprotein binding protein (HDLBP, Vigilin) is incorporated into HIV-1 Gag virus-like particles PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16432

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables cadherin binding HDA PubMed 
    enables lipid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of high-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    vigilin
    Names
    HDL-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243900.3 → NP_001230829.1  vigilin isoform b

      See identical proteins and their annotated locations for NP_001230829.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses a downstream promoter compared to variant 1.
      Source sequence(s)
      AC104841, AI434711, AK300312, BP359370
      Consensus CDS
      CCDS58760.1
      UniProtKB/TrEMBL
      B2R5V9
      Related
      ENSP00000399139.2, ENST00000427183.6
      Conserved Domains (1) summary
      cd02394
      Location:622 → 684
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...

    2. NM_001320965.3 → NP_001307894.1  vigilin isoform a

      Status: REVIEWED

      Source sequence(s)
      AC104841, AI434711, AK312335, DC400438
      Consensus CDS
      CCDS2547.1
      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9
      Related
      ENSP00000375837.2, ENST00000391976.6
      Conserved Domains (15) summary
      cd02394
      Location:435 → 502
      KH-I_Vigilin_rpt6; sixth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22405
      Location:77 → 144
      KH-I_Vigilin_rpt1; first type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22406
      Location:147 → 221
      KH-I_Vigilin_rpt2; second type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22407
      Location:224 → 283
      KH-I_Vigilin_rpt3; third type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22408
      Location:297 → 358
      KH-I_Vigilin_rpt4; fourth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22409
      Location:364 → 433
      KH-I_Vigilin_rpt5; fifth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22410
      Location:507 → 573
      KH-I_Vigilin_rpt7; seventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22411
      Location:583 → 644
      KH-I_Vigilin_rpt8; eighth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22412
      Location:653 → 722
      KH-I_Vigilin_rpt9; ninth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22413
      Location:726 → 791
      KH-I_Vigilin_rpt10; tenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22414
      Location:802 → 867
      KH-I_Vigilin_rpt11; eleventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22415
      Location:875 → 970
      KH-I_Vigilin_rpt12; twelfth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22416
      Location:972 → 1049
      KH-I_Vigilin_rpt13; thirteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22417
      Location:1053 → 1126
      KH-I_Vigilin_rpt14; fourteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22418
      Location:1128 → 1196
      KH-I_Vigilin_rpt15; fifteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins

    3. NM_001320966.3 → NP_001307895.1  vigilin isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses a downstream promoter compared to variant 1.
      Source sequence(s)
      AC104841, AI434711, AK312335, BP283713
      Consensus CDS
      CCDS2547.1
      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9
      Conserved Domains (15) summary
      cd02394
      Location:435 → 502
      KH-I_Vigilin_rpt6; sixth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22405
      Location:77 → 144
      KH-I_Vigilin_rpt1; first type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22406
      Location:147 → 221
      KH-I_Vigilin_rpt2; second type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22407
      Location:224 → 283
      KH-I_Vigilin_rpt3; third type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22408
      Location:297 → 358
      KH-I_Vigilin_rpt4; fourth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22409
      Location:364 → 433
      KH-I_Vigilin_rpt5; fifth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22410
      Location:507 → 573
      KH-I_Vigilin_rpt7; seventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22411
      Location:583 → 644
      KH-I_Vigilin_rpt8; eighth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22412
      Location:653 → 722
      KH-I_Vigilin_rpt9; ninth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22413
      Location:726 → 791
      KH-I_Vigilin_rpt10; tenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22414
      Location:802 → 867
      KH-I_Vigilin_rpt11; eleventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22415
      Location:875 → 970
      KH-I_Vigilin_rpt12; twelfth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22416
      Location:972 → 1049
      KH-I_Vigilin_rpt13; thirteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22417
      Location:1053 → 1126
      KH-I_Vigilin_rpt14; fourteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22418
      Location:1128 → 1196
      KH-I_Vigilin_rpt15; fifteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins

    4. NM_001320967.3 → NP_001307896.1  vigilin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses a downstream promoter compared to variant 1.
      Source sequence(s)
      AC104841, AI434711, AK312335, BP359370, DB282620
      UniProtKB/TrEMBL
      B2R5V9
      Conserved Domains (1) summary
      cd02394
      Location:655 → 717
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...

    5. NM_005336.6 → NP_005327.1  vigilin isoform a

      See identical proteins and their annotated locations for NP_005327.1

      Status: REVIEWED

      Source sequence(s)
      AC104841, KF456779
      Consensus CDS
      CCDS2547.1
      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9
      Related
      ENSP00000312042.4, ENST00000310931.10
      Conserved Domains (15) summary
      cd02394
      Location:435 → 502
      KH-I_Vigilin_rpt6; sixth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22405
      Location:77 → 144
      KH-I_Vigilin_rpt1; first type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22406
      Location:147 → 221
      KH-I_Vigilin_rpt2; second type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22407
      Location:224 → 283
      KH-I_Vigilin_rpt3; third type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22408
      Location:297 → 358
      KH-I_Vigilin_rpt4; fourth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22409
      Location:364 → 433
      KH-I_Vigilin_rpt5; fifth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22410
      Location:507 → 573
      KH-I_Vigilin_rpt7; seventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22411
      Location:583 → 644
      KH-I_Vigilin_rpt8; eighth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22412
      Location:653 → 722
      KH-I_Vigilin_rpt9; ninth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22413
      Location:726 → 791
      KH-I_Vigilin_rpt10; tenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22414
      Location:802 → 867
      KH-I_Vigilin_rpt11; eleventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22415
      Location:875 → 970
      KH-I_Vigilin_rpt12; twelfth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22416
      Location:972 → 1049
      KH-I_Vigilin_rpt13; thirteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22417
      Location:1053 → 1126
      KH-I_Vigilin_rpt14; fourteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22418
      Location:1128 → 1196
      KH-I_Vigilin_rpt15; fifteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins

    6. NM_203346.6 → NP_976221.1  vigilin isoform a

      See identical proteins and their annotated locations for NP_976221.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a downstream promoter compared to variant 1.
      Source sequence(s)
      AC104841, AI434711, AK312335, BP359370, DB282620
      Consensus CDS
      CCDS2547.1
      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9
      Related
      ENSP00000375836.1, ENST00000391975.5
      Conserved Domains (15) summary
      cd02394
      Location:435 → 502
      KH-I_Vigilin_rpt6; sixth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22405
      Location:77 → 144
      KH-I_Vigilin_rpt1; first type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22406
      Location:147 → 221
      KH-I_Vigilin_rpt2; second type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22407
      Location:224 → 283
      KH-I_Vigilin_rpt3; third type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22408
      Location:297 → 358
      KH-I_Vigilin_rpt4; fourth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22409
      Location:364 → 433
      KH-I_Vigilin_rpt5; fifth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22410
      Location:507 → 573
      KH-I_Vigilin_rpt7; seventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22411
      Location:583 → 644
      KH-I_Vigilin_rpt8; eighth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22412
      Location:653 → 722
      KH-I_Vigilin_rpt9; ninth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22413
      Location:726 → 791
      KH-I_Vigilin_rpt10; tenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22414
      Location:802 → 867
      KH-I_Vigilin_rpt11; eleventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22415
      Location:875 → 970
      KH-I_Vigilin_rpt12; twelfth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22416
      Location:972 → 1049
      KH-I_Vigilin_rpt13; thirteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22417
      Location:1053 → 1126
      KH-I_Vigilin_rpt14; fourteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22418
      Location:1128 → 1196
      KH-I_Vigilin_rpt15; fifteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      241227291..241315672 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017003941.3 → XP_016859430.1  vigilin isoform X2

      UniProtKB/TrEMBL
      B2R5V9
      Conserved Domains (1) summary
      cd02394
      Location:655 → 717
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...

    2. XM_011511060.4 → XP_011509362.1  vigilin isoform X1

      See identical proteins and their annotated locations for XP_011509362.1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9
      Conserved Domains (15) summary
      cd02394
      Location:435 → 502
      KH-I_Vigilin_rpt6; sixth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22405
      Location:77 → 144
      KH-I_Vigilin_rpt1; first type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22406
      Location:147 → 221
      KH-I_Vigilin_rpt2; second type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22407
      Location:224 → 283
      KH-I_Vigilin_rpt3; third type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22408
      Location:297 → 358
      KH-I_Vigilin_rpt4; fourth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22409
      Location:364 → 433
      KH-I_Vigilin_rpt5; fifth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22410
      Location:507 → 573
      KH-I_Vigilin_rpt7; seventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22411
      Location:583 → 644
      KH-I_Vigilin_rpt8; eighth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22412
      Location:653 → 722
      KH-I_Vigilin_rpt9; ninth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22413
      Location:726 → 791
      KH-I_Vigilin_rpt10; tenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22414
      Location:802 → 867
      KH-I_Vigilin_rpt11; eleventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22415
      Location:875 → 970
      KH-I_Vigilin_rpt12; twelfth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22416
      Location:972 → 1049
      KH-I_Vigilin_rpt13; thirteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22417
      Location:1053 → 1126
      KH-I_Vigilin_rpt14; fourteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22418
      Location:1128 → 1196
      KH-I_Vigilin_rpt15; fifteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins

    3. XM_011511058.4 → XP_011509360.1  vigilin isoform X1

      See identical proteins and their annotated locations for XP_011509360.1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9
      Conserved Domains (15) summary
      cd02394
      Location:435 → 502
      KH-I_Vigilin_rpt6; sixth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22405
      Location:77 → 144
      KH-I_Vigilin_rpt1; first type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22406
      Location:147 → 221
      KH-I_Vigilin_rpt2; second type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22407
      Location:224 → 283
      KH-I_Vigilin_rpt3; third type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22408
      Location:297 → 358
      KH-I_Vigilin_rpt4; fourth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22409
      Location:364 → 433
      KH-I_Vigilin_rpt5; fifth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22410
      Location:507 → 573
      KH-I_Vigilin_rpt7; seventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22411
      Location:583 → 644
      KH-I_Vigilin_rpt8; eighth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22412
      Location:653 → 722
      KH-I_Vigilin_rpt9; ninth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22413
      Location:726 → 791
      KH-I_Vigilin_rpt10; tenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22414
      Location:802 → 867
      KH-I_Vigilin_rpt11; eleventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22415
      Location:875 → 970
      KH-I_Vigilin_rpt12; twelfth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22416
      Location:972 → 1049
      KH-I_Vigilin_rpt13; thirteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22417
      Location:1053 → 1126
      KH-I_Vigilin_rpt14; fourteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22418
      Location:1128 → 1196
      KH-I_Vigilin_rpt15; fifteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins

    4. XM_024452833.2 → XP_024308601.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9
      Conserved Domains (15) summary
      cd02394
      Location:435 → 502
      KH-I_Vigilin_rpt6; sixth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22405
      Location:77 → 144
      KH-I_Vigilin_rpt1; first type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22406
      Location:147 → 221
      KH-I_Vigilin_rpt2; second type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22407
      Location:224 → 283
      KH-I_Vigilin_rpt3; third type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22408
      Location:297 → 358
      KH-I_Vigilin_rpt4; fourth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22409
      Location:364 → 433
      KH-I_Vigilin_rpt5; fifth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22410
      Location:507 → 573
      KH-I_Vigilin_rpt7; seventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22411
      Location:583 → 644
      KH-I_Vigilin_rpt8; eighth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22412
      Location:653 → 722
      KH-I_Vigilin_rpt9; ninth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22413
      Location:726 → 791
      KH-I_Vigilin_rpt10; tenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22414
      Location:802 → 867
      KH-I_Vigilin_rpt11; eleventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22415
      Location:875 → 970
      KH-I_Vigilin_rpt12; twelfth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22416
      Location:972 → 1049
      KH-I_Vigilin_rpt13; thirteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22417
      Location:1053 → 1126
      KH-I_Vigilin_rpt14; fourteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22418
      Location:1128 → 1196
      KH-I_Vigilin_rpt15; fifteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins

    5. XM_047444077.1 → XP_047300033.1  vigilin isoform X2

      UniProtKB/TrEMBL
      B2R5V9

    6. XM_047444067.1 → XP_047300023.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    7. XM_047444073.1 → XP_047300029.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    8. XM_047444079.1 → XP_047300035.1  vigilin isoform X2

      UniProtKB/TrEMBL
      B2R5V9

    9. XM_047444068.1 → XP_047300024.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    10. XM_047444071.1 → XP_047300027.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    11. XM_047444070.1 → XP_047300026.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    12. XM_017003942.2 → XP_016859431.1  vigilin isoform X2

      UniProtKB/TrEMBL
      B2R5V9
      Conserved Domains (1) summary
      cd02394
      Location:655 → 717
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...

    13. XM_005247002.5 → XP_005247059.2  vigilin isoform X1

      See identical proteins and their annotated locations for XP_005247059.2

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9
      Conserved Domains (15) summary
      cd02394
      Location:435 → 502
      KH-I_Vigilin_rpt6; sixth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22405
      Location:77 → 144
      KH-I_Vigilin_rpt1; first type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22406
      Location:147 → 221
      KH-I_Vigilin_rpt2; second type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22407
      Location:224 → 283
      KH-I_Vigilin_rpt3; third type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22408
      Location:297 → 358
      KH-I_Vigilin_rpt4; fourth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22409
      Location:364 → 433
      KH-I_Vigilin_rpt5; fifth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22410
      Location:507 → 573
      KH-I_Vigilin_rpt7; seventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22411
      Location:583 → 644
      KH-I_Vigilin_rpt8; eighth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22412
      Location:653 → 722
      KH-I_Vigilin_rpt9; ninth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22413
      Location:726 → 791
      KH-I_Vigilin_rpt10; tenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22414
      Location:802 → 867
      KH-I_Vigilin_rpt11; eleventh type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22415
      Location:875 → 970
      KH-I_Vigilin_rpt12; twelfth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22416
      Location:972 → 1049
      KH-I_Vigilin_rpt13; thirteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22417
      Location:1053 → 1126
      KH-I_Vigilin_rpt14; fourteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
      cd22418
      Location:1128 → 1196
      KH-I_Vigilin_rpt15; fifteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins

    14. XM_047444078.1 → XP_047300034.1  vigilin isoform X2

      UniProtKB/TrEMBL
      B2R5V9

    15. XM_047444075.1 → XP_047300031.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    16. XM_047444069.1 → XP_047300025.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    17. XM_047444076.1 → XP_047300032.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    18. XM_047444072.1 → XP_047300028.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    19. XM_047444074.1 → XP_047300030.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      241726284..241814658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341627.1 → XP_054197602.1  vigilin isoform X2

      UniProtKB/TrEMBL
      B2R5V9

    2. XM_054341615.1 → XP_054197590.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    3. XM_054341620.1 → XP_054197595.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    4. XM_054341626.1 → XP_054197601.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    5. XM_054341625.1 → XP_054197600.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    6. XM_054341629.1 → XP_054197604.1  vigilin isoform X2

      UniProtKB/TrEMBL
      B2R5V9

    7. XM_054341628.1 → XP_054197603.1  vigilin isoform X2

      UniProtKB/TrEMBL
      B2R5V9

    8. XM_054341613.1 → XP_054197588.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    9. XM_054341621.1 → XP_054197596.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    10. XM_054341632.1 → XP_054197607.1  vigilin isoform X2

      UniProtKB/TrEMBL
      B2R5V9

    11. XM_054341614.1 → XP_054197589.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    12. XM_054341618.1 → XP_054197593.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    13. XM_054341630.1 → XP_054197605.1  vigilin isoform X2

      UniProtKB/TrEMBL
      B2R5V9

    14. XM_054341617.1 → XP_054197592.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    15. XM_054341624.1 → XP_054197599.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    16. XM_054341619.1 → XP_054197594.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    17. XM_054341631.1 → XP_054197606.1  vigilin isoform X2

      UniProtKB/TrEMBL
      B2R5V9

    18. XM_054341623.1 → XP_054197598.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    19. XM_054341616.1 → XP_054197591.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9

    20. XM_054341622.1 → XP_054197597.1  vigilin isoform X1

      UniProtKB/Swiss-Prot
      B4DTQ2, E7EM71, Q00341, Q53QU2, Q9UCY3
      UniProtKB/TrEMBL
      A0A024R4E5, A0A0A0MR28, A0A9K3Y7D7, B2R5V9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00341.3 GenPept UniProtKB/Swiss-Prot:Q00341

    Gene LinkOut

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