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    PPP3CB protein phosphatase 3 catalytic subunit beta [ Homo sapiens (human) ]

    Gene ID: 5532, updated on 10-Dec-2024

    Summary

    Official Symbol
    PPP3CBprovided by HGNC
    Official Full Name
    protein phosphatase 3 catalytic subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:9315
    See related
    Ensembl:ENSG00000107758 MIM:114106; AllianceGenome:HGNC:9315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CNA2; CALNB; CALNA2; PP2Bbeta
    Summary
    Enables several functions, including calmodulin binding activity; calmodulin-dependent protein phosphatase activity; and protein phosphatase 2B binding activity. Involved in several processes, including calcineurin-NFAT signaling cascade; positive regulation of lysosome organization; and positive regulation of protein localization to nucleus. Located in cytoplasm. Part of calcineurin complex. Implicated in aortic valve stenosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 40.2), fat (RPKM 17.4) and 24 other tissues See more
    Orthologs
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    Genomic context

    See PPP3CB in Genome Data Viewer
    Location:
    10q22.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73436433..73496024, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74307846..74367439, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75196191..75255782, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L26 pseudogene 6 Neighboring gene MSS51 mitochondrial translational activator Neighboring gene MPRA-validated peak1010 silencer Neighboring gene MPRA-validated peak1011 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3564 Neighboring gene PPP3CB antisense RNA 1 (head to head) Neighboring gene ubiquitin specific peptidase 54 Neighboring gene Sharpr-MPRA regulatory region 13746 Neighboring gene RNA, U6 small nuclear 883, pseudogene Neighboring gene ribosomal protein S26 pseudogene 41

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-induced dephosphorylation of KV2.1 is dependent on NMDA receptor-mediated activation of protein phosphatase 2B or calcineurin PubMed
    Tat tat Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT, suggesting Tat activates calcineurin PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity  
    enables calcium ion binding PubMed 
    enables calmodulin binding  
    enables calmodulin binding PubMed 
    enables calmodulin binding PubMed 
    enables calmodulin-dependent protein phosphatase activity  
    enables calmodulin-dependent protein phosphatase activity PubMed 
    enables calmodulin-dependent protein phosphatase activity  
    enables calmodulin-dependent protein phosphatase activity PubMed 
    enables enzyme binding PubMed 
    enables histone H2AXS140 phosphatase activity  
    enables myosin phosphatase activity  
    enables protein binding PubMed 
    enables protein dimerization activity PubMed 
    enables protein phosphatase 2B binding PubMed 
    enables protein serine/threonine phosphatase activity PubMed 
    Items 1 - 25 of 37
    Process Evidence Code Pubs
    involved_in T cell activation PubMed 
    involved_in T cell differentiation  
    involved_in T cell homeostasis  
    involved_in T cell mediated cytotoxicity  
    involved_in T cell proliferation PubMed 
    involved_in axon extension PubMed 
    involved_in calcineurin-NFAT signaling cascade PubMed 
    involved_in calcineurin-mediated signaling  
    involved_in calcineurin-mediated signaling PubMed 
    involved_in calcium-ion regulated exocytosis  
    involved_in chromatin remodeling  
    involved_in dephosphorylation PubMed 
    involved_in heart development  
    involved_in learning PubMed 
    involved_in locomotion involved in locomotory behavior  
    involved_in lymphangiogenesis  
    involved_in memory PubMed 
    involved_in negative regulation of T cell mediated cytotoxicity  
    involved_in negative regulation of calcium ion import across plasma membrane PubMed 
    involved_in negative regulation of signaling  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of calcineurin-NFAT signaling cascade PubMed 
    involved_in positive regulation of calcium ion import across plasma membrane PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus  
    involved_in positive regulation of lysosome organization PubMed 
    involved_in positive regulation of protein localization to nucleus PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in protein dephosphorylation PubMed 
    involved_in protein dephosphorylation  
    involved_in protein phosphorylation  
    involved_in regulation of insulin secretion  
    involved_in regulation of synaptic plasticity PubMed 
    involved_in regulation of synaptic vesicle endocytosis  
    involved_in response to cytokine  
    involved_in response to stress  
    involved_in signal transduction PubMed 
    involved_in skeletal muscle fiber development  
    Items 1 - 25 of 37
    Component Evidence Code Pubs
    located_in T-tubule  
    located_in Z disc  
    part_of calcineurin complex  
    part_of calcineurin complex PubMed 
    part_of calcineurin complex PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytosol PubMed 
    located_in cytosol  
    located_in glutamatergic synapse  
    located_in nucleoplasm  
    located_in plasma membrane  
    part_of protein serine/threonine phosphatase complex PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
    Names
    CAM-PRP catalytic subunit
    CNA beta
    calcineurin A beta
    calcineurin A2
    protein phosphatase 3, catalytic subunit, beta isozyme
    protein phosphatase from PCR fragment H32
    NP_001135825.1
    NP_001135826.1
    NP_001276897.1
    NP_001276898.1
    NP_066955.1
    XP_005270001.1
    XP_047281382.1
    XP_047281383.1
    XP_047281384.1
    XP_047281385.1
    XP_047281386.1
    XP_047281387.1
    XP_047281388.1
    XP_047281389.1
    XP_047281390.1
    XP_054222186.1
    XP_054222187.1
    XP_054222188.1
    XP_054222189.1
    XP_054222190.1
    XP_054222191.1
    XP_054222192.1
    XP_054222193.1
    XP_054222194.1
    XP_054222195.1
    XP_054222196.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142353.3 → NP_001135825.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform a

      See identical proteins and their annotated locations for NP_001135825.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      BC028049, BX114972, DA854064
      Consensus CDS
      CCDS44437.1
      UniProtKB/TrEMBL
      Q5F2F8
      Related
      ENSP00000378306.2, ENST00000394829.6
      Conserved Domains (1) summary
      cd07416
      Location:50 → 354
      MPP_PP2B; PP2B, metallophosphatase domain
    2. NM_001142354.3 → NP_001135826.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform c

      See identical proteins and their annotated locations for NP_001135826.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform c, which is shorter than isoform a.
      Source sequence(s)
      AJ488506, BX114972, DA854064
      Consensus CDS
      CCDS44436.1
      UniProtKB/TrEMBL
      Q5F2F8
      Related
      ENSP00000378305.2, ENST00000394828.6
      Conserved Domains (1) summary
      cd07416
      Location:50 → 354
      MPP_PP2B; PP2B, metallophosphatase domain
    3. NM_001289968.2 → NP_001276897.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform d

      See identical proteins and their annotated locations for NP_001276897.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region, one of which results in a frameshift and early stop codon, compared to variant 1. The resulting protein (isoform d) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK301582, CA429703, DA128707, M29550
      UniProtKB/TrEMBL
      Q5F2F8
      Related
      ENSP00000343147.3, ENST00000342558.3
      Conserved Domains (2) summary
      smart00156
      Location:67 → 356
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:50 → 372
      MPP_PP2B; PP2B, metallophosphatase domain
    4. NM_001289969.2 → NP_001276898.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform e

      See identical proteins and their annotated locations for NP_001276898.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region, one of which results in a frameshift and early stop codon, compared to variant 1. The resulting protein (isoform e) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK301582, AL359074, CA429703, DB479220, M29550
      UniProtKB/TrEMBL
      B7Z781
      Conserved Domains (2) summary
      cd07416
      Location:1 → 268
      MPP_PP2B; PP2B, metallophosphatase domain
      pfam00149
      Location:7 → 205
      Metallophos; Calcineurin-like phosphoesterase
    5. NM_021132.4 → NP_066955.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform b

      See identical proteins and their annotated locations for NP_066955.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform b which is shorter than isoform a.
      Source sequence(s)
      BC028049, BC035464, BX114972, DA854064
      Consensus CDS
      CCDS7328.1
      UniProtKB/Swiss-Prot
      P16298, P16299, Q5F2F9, Q8N1F0, Q8N3W4
      UniProtKB/TrEMBL
      Q5F2F8
      Related
      ENSP00000353881.5, ENST00000360663.10
      Conserved Domains (1) summary
      cd07416
      Location:50 → 354
      MPP_PP2B; PP2B, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      73436433..73496024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005269944.2 → XP_005270001.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3

      See identical proteins and their annotated locations for XP_005270001.1

      UniProtKB/TrEMBL
      Q5F2F8
      Conserved Domains (1) summary
      cd07416
      Location:50 → 354
      MPP_PP2B; PP2B, metallophosphatase domain
    2. XM_047425427.1 → XP_047281383.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2

      UniProtKB/TrEMBL
      Q5F2F8
    3. XM_047425426.1 → XP_047281382.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1

      UniProtKB/TrEMBL
      Q5F2F8
    4. XM_047425430.1 → XP_047281386.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4

      UniProtKB/TrEMBL
      B7Z781
    5. XM_047425434.1 → XP_047281390.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X8

      UniProtKB/TrEMBL
      B7Z781
    6. XM_047425432.1 → XP_047281388.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X6

      UniProtKB/TrEMBL
      B7Z781
    7. XM_047425433.1 → XP_047281389.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7

      UniProtKB/TrEMBL
      B7Z781
    8. XM_047425431.1 → XP_047281387.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X5

      UniProtKB/TrEMBL
      B7Z781
    9. XM_047425428.1 → XP_047281384.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4

      UniProtKB/TrEMBL
      B7Z781
    10. XM_047425429.1 → XP_047281385.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4

      UniProtKB/TrEMBL
      B7Z781

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      74307846..74367439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366213.1 → XP_054222188.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3

      UniProtKB/TrEMBL
      Q5F2F8
    2. XM_054366212.1 → XP_054222187.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2

      UniProtKB/TrEMBL
      Q5F2F8
    3. XM_054366211.1 → XP_054222186.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1

      UniProtKB/TrEMBL
      Q5F2F8
    4. XM_054366216.1 → XP_054222191.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4

      UniProtKB/TrEMBL
      B7Z781
    5. XM_054366221.1 → XP_054222196.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X8

      UniProtKB/TrEMBL
      B7Z781
    6. XM_054366219.1 → XP_054222194.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X6

      UniProtKB/TrEMBL
      B7Z781
    7. XM_054366220.1 → XP_054222195.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7

      UniProtKB/TrEMBL
      B7Z781
    8. XM_054366218.1 → XP_054222193.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X5

      UniProtKB/TrEMBL
      B7Z781
    9. XM_054366214.1 → XP_054222189.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4

      UniProtKB/TrEMBL
      B7Z781
    10. XM_054366215.1 → XP_054222190.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4

      UniProtKB/TrEMBL
      B7Z781
    11. XM_054366217.1 → XP_054222192.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4

      UniProtKB/TrEMBL
      B7Z781
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