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    UTP14A UTP14A small subunit processome component [ Homo sapiens (human) ]

    Gene ID: 10813, updated on 10-Dec-2024

    Summary

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    Official Symbol
    UTP14Aprovided by HGNC
    Official Full Name
    UTP14A small subunit processome componentprovided by HGNC
    Primary source
    HGNC:HGNC:10665
    See related
    Ensembl:ENSG00000156697 MIM:300508; AllianceGenome:HGNC:10665
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Utp14; NYCO16; SDCCAG16; dJ537K23.3
    Summary
    This gene encodes a member of the uridine triphosphate 14 family. As an essential component of a large ribonucleoprotein complex bound to the U3 small nucleolar RNA, the encoded protein is involved in ribosome biogenesis and 18S rRNA synthesis. An autosomal retrotransposed copy of this X-linked gene exists on chromosome 13. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
    Expression
    Ubiquitous expression in lymph node (RPKM 5.9), appendix (RPKM 5.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See UTP14A in Genome Data Viewer
    Location:
    Xq26.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (129906164..129929752)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (128224954..128248543)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (129040140..129063728)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type palmitoyltransferase 9 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:128983483-128984298 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:128984299-128985112 Neighboring gene spalt like transcription factor 4 pseudogene 2 Neighboring gene uncharacterized LOC105373335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29931 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20983 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20984 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129086824-129087554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129093062-129093562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20985 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:129117440-129117676 Neighboring gene BCL6 corepressor like 1 Neighboring gene uncharacterized LOC124905216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:129159157-129159656 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20986 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20988 Neighboring gene Sharpr-MPRA regulatory region 15346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20989 Neighboring gene Sharpr-MPRA regulatory region 9263 Neighboring gene E74 like ETS transcription factor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20994 Neighboring gene RAB33A, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [Expression of hUTP14a in non-small cell lung cancer]. Zhang CF, et al. Beijing Da Xue Xue Bao Yi Xue Ban, 2019 Feb 18. PMID 30773559, Free PMC Article
    2. Overexpression of U three protein 14a (UTP14a) is associated with poor prognosis of esophageal squamous cell carcinoma. Li KK, et al. Thorac Cancer, 2019 Nov. PMID 31496055, Free PMC Article
    3. Human U3 protein 14a plays an anti-apoptotic role in cancer cells. Ma T, et al. Biol Chem, 2017 Oct 26. PMID 28672776
    4. Human U Three Protein 14a Expression is Increased in Hepatocellular Carcinoma and Associated with Poor Prognosis. Zhang JY, et al. Chin Med J (Engl), 2017 Feb 20. PMID 28218222, Free PMC Article
    5. Human UTP14a promotes angiogenesis through upregulating PDGFA expression in colorectal cancer. Ren P, et al. Biochem Biophys Res Commun, 2019 May 14. PMID 30929921

    See all (119) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that UTP14a expression is correlated with tumor proliferation and invasion; higher expression of UTP14a is a predictor of poor prognosis in patients with esophageal squamous cell carcinoma (ESCC). Additionally, knockdown of UTP14a inhibits cell proliferation and invasion in ESCC cell line, ECA109.
      Title: Overexpression of U three protein 14a (UTP14a) is associated with poor prognosis of esophageal squamous cell carcinoma.
    2. UTP14a promotes angiogenesis through upregulating transcription and secretion of PDGFA in colorectal cancer.
      Title: Human UTP14a promotes angiogenesis through upregulating PDGFA expression in colorectal cancer.
    3. hUTP14a interacts with c-Myc and protects c-Myc from ubiquitination and degradation in a USP36-dependent way.
      Title: Human UTP14a promotes colorectal cancer progression by forming a positive regulation loop with c-Myc.
    4. suggesting that hUTP14a might possess a potential as a candidate marker for the early diagnosis screening of non-small cell lung cancer
      Title: [Expression of hUTP14a in non-small cell lung cancer].
    5. The hUTP14a protected tumor cells from chemotherapeutic drug-induced apoptosis and thus might possess a potential as a target for anti-tumor therapy.
      Title: Human U3 protein 14a plays an anti-apoptotic role in cancer cells.
    6. The positivity rate of hUTP14a expression was significantly higher in HCC specimens. Positive expression of nucleolar hUTP14a might act as a novel prognostic predictor for patients with HCC
      Title: Human U Three Protein 14a Expression is Increased in Hepatocellular Carcinoma and Associated with Poor Prognosis.
    7. hUTP14a physically interacts with p53 and functionally promotes p53 turn-over
      Title: A small ribosomal subunit (SSU) processome component, the human U3 protein 14A (hUTP14A) binds p53 and promotes p53 degradation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ37089, KIAA0266

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    U3 small nucleolar RNA-associated protein 14 homolog A
    Names
    UTP14, U3 small nucleolar ribonucleoprotein, homolog A
    UTP14A small subunit (SSU) processome component
    antigen NY-CO-16
    serologically defined colon cancer antigen 16

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166221.2 → NP_001159693.1  U3 small nucleolar RNA-associated protein 14 homolog A isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AK291918, AK298578, BQ017502, BU942896
      Consensus CDS
      CCDS55489.1
      UniProtKB/TrEMBL
      B4E343
      Related
      ENSP00000388669.2, ENST00000425117.6
      Conserved Domains (1) summary
      pfam04615
      Location:29 → 681
      Utp14; Utp14 protein

    2. NM_006649.4 → NP_006640.2  U3 small nucleolar RNA-associated protein 14 homolog A isoform 1

      See identical proteins and their annotated locations for NP_006640.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK291918, BQ017502
      Consensus CDS
      CCDS14615.1
      UniProtKB/Swiss-Prot
      A8K7A3, A8MVQ1, B4DQ08, E9PEL7, Q5JYF1, Q9BVJ6
      UniProtKB/TrEMBL
      B4E343
      Related
      ENSP00000377944.3, ENST00000394422.8
      Conserved Domains (1) summary
      pfam04615
      Location:29 → 733
      Utp14; Utp14 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      129906164..129929752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441790.1 → XP_047297746.1  U3 small nucleolar RNA-associated protein 14 homolog A isoform X1

      UniProtKB/TrEMBL
      B4E343

    2. XM_047441791.1 → XP_047297747.1  U3 small nucleolar RNA-associated protein 14 homolog A isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      128224954..128248543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326402.1 → XP_054182377.1  U3 small nucleolar RNA-associated protein 14 homolog A isoform X1

      UniProtKB/TrEMBL
      B4E343

    2. XM_054326403.1 → XP_054182378.1  U3 small nucleolar RNA-associated protein 14 homolog A isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BVJ6.1 GenPept UniProtKB/Swiss-Prot:Q9BVJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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