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    ZC3H12B zinc finger CCCH-type containing 12B [ Homo sapiens (human) ]

    Gene ID: 340554, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZC3H12Bprovided by HGNC
    Official Full Name
    zinc finger CCCH-type containing 12Bprovided by HGNC
    Primary source
    HGNC:HGNC:17407
    See related
    Ensembl:ENSG00000102053 MIM:300889; AllianceGenome:HGNC:17407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCPIP2; CXorf32
    Summary
    The protein encoded by this gene belongs to a family of CCCH-type zinc finger proteins that are involved in the proinflammatory activation of macrophages. The exact function of this family member is unknown, but it is thought to function as a ribonuclease. [provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in brain (RPKM 1.1), ovary (RPKM 0.5) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZC3H12B in Genome Data Viewer
    Location:
    Xq11.2-q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (65034826..65507887)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (63460180..63934332)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (64254706..64727767)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373239 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:64195850-64196393 Neighboring gene zinc finger C4H2-type containing Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20879 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29712 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:64394379-64394544 Neighboring gene karyopherin subunit alpha 2 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:64416296-64416796 Neighboring gene Sharpr-MPRA regulatory region 9838 Neighboring gene NANOG hESC enhancer GRCh37_chrX:64519957-64520668 Neighboring gene chaperonin containing TCP1 subunit 4 pseudogene 2 Neighboring gene mortality factor 4 like 1 pseudogene 5 Neighboring gene NANOG hESC enhancer GRCh37_chrX:64612699-64613200 Neighboring gene PRXL2C pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chrX:64658617-64659137 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:64683306-64683834 Neighboring gene TLE family member 1 pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:64713210-64713789 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:64722192-64722692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:64722693-64723193 Neighboring gene AP1M2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29713 Neighboring gene LAS1 like ribosome biogenesis factor Neighboring gene FERM domain containing 8 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The homeostatic function of Regnase-2 restricts neuroinflammation. Sowinska W, et al. FASEB J, 2023 Mar. PMID 36753401, Free PMC Article
    2. Bayesian Genome-wide TWAS Method to Leverage both cis- and trans-eQTL Information through Summary Statistics. Luningham JM, et al. Am J Hum Genet, 2020 Oct 1. PMID 32961112, Free PMC Article
    3. ZC3H12B/MCPIP2, a new active member of the ZC3H12 family. Wawro M, et al. RNA, 2019 Jul. PMID 30988100, Free PMC Article
    4. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. Liang J, et al. J Biol Chem, 2008 Mar 7. PMID 18178554
    5. POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1. Wang B, et al. EBioMedicine, 2019 Mar. PMID 30745168, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The homeostatic function of Regnase-2 restricts neuroinflammation.
      Title: The homeostatic function of Regnase-2 restricts neuroinflammation.
    2. Bayesian Genome-wide TWAS Method to Leverage both cis- and trans-eQTL Information through Summary Statistics.
      Title: Bayesian Genome-wide TWAS Method to Leverage both cis- and trans-eQTL Information through Summary Statistics.
    3. MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage activation.
      Title: A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable ribonuclease ZC3H12B
    Names
    MCP-induced protein 2
    zinc finger CCCH domain-containing protein 12B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021264.2 RefSeqGene

      Range
      5001..24153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001010888.4 → NP_001010888.3  probable ribonuclease ZC3H12B

      See identical proteins and their annotated locations for NP_001010888.3

      Status: VALIDATED

      Source sequence(s)
      AL050306, AL355606, AL441964, AL591202, Z83841
      Consensus CDS
      CCDS48131.2
      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69
      Related
      ENSP00000340839.4, ENST00000338957.5
      Conserved Domains (1) summary
      pfam11977
      Location:189 → 345
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      65034826..65507887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442075.1 → XP_047298031.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    2. XM_047442077.1 → XP_047298033.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    3. XM_047442076.1 → XP_047298032.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    4. XM_047442074.1 → XP_047298030.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    5. XM_047442079.1 → XP_047298035.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    6. XM_017029484.2 → XP_016884973.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69
      Conserved Domains (1) summary
      pfam11977
      Location:189 → 345
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

    7. XM_047442078.1 → XP_047298034.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    8. XM_047442080.1 → XP_047298036.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    9. XM_017029479.2 → XP_016884968.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69
      Conserved Domains (1) summary
      pfam11977
      Location:189 → 345
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

    10. XM_017029480.2 → XP_016884969.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69
      Conserved Domains (1) summary
      pfam11977
      Location:189 → 345
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

    11. XM_017029481.2 → XP_016884970.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69
      Conserved Domains (1) summary
      pfam11977
      Location:189 → 345
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

    12. XM_017029482.2 → XP_016884971.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69
      Conserved Domains (1) summary
      pfam11977
      Location:189 → 345
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

    13. XM_017029483.2 → XP_016884972.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69
      Conserved Domains (1) summary
      pfam11977
      Location:189 → 345
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

    14. XM_011530939.3 → XP_011529241.1  probable ribonuclease ZC3H12B isoform X1

      See identical proteins and their annotated locations for XP_011529241.1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69
      Related
      ENSP00000512584.1, ENST00000696370.1
      Conserved Domains (1) summary
      pfam11977
      Location:189 → 345
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      63460180..63934332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326986.1 → XP_054182961.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    2. XM_054326980.1 → XP_054182955.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    3. XM_054326981.1 → XP_054182956.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    4. XM_054326975.1 → XP_054182950.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    5. XM_054326985.1 → XP_054182960.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    6. XM_054326983.1 → XP_054182958.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    7. XM_054326984.1 → XP_054182959.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    8. XM_054326987.1 → XP_054182962.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    9. XM_054326976.1 → XP_054182951.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    10. XM_054326977.1 → XP_054182952.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    11. XM_054326978.1 → XP_054182953.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    12. XM_054326979.1 → XP_054182954.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    13. XM_054326982.1 → XP_054182957.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69

    14. XM_054326988.1 → XP_054182963.1  probable ribonuclease ZC3H12B isoform X1

      UniProtKB/Swiss-Prot
      B2RTQ3, E9PAJ6, Q5H9C0, Q5HYM0
      UniProtKB/TrEMBL
      A0A8Q3WM69
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HYM0.3 GenPept UniProtKB/Swiss-Prot:Q5HYM0

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