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    Xpo7 exportin 7 [ Mus musculus (house mouse) ]

    Gene ID: 65246, updated on 9-Dec-2024

    Summary

    Official Symbol
    Xpo7provided by MGI
    Official Full Name
    exportin 7provided by MGI
    Primary source
    MGI:MGI:1929705
    See related
    Ensembl:ENSMUSG00000022100 AllianceGenome:MGI:1929705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    exp7; Ranbp16; 4930506C02Rik
    Summary
    Predicted to enable nuclear export signal receptor activity. Predicted to be involved in protein export from nucleus. Predicted to act upstream of or within nucleocytoplasmic transport. Predicted to be located in nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. Is expressed in heart and liver. Orthologous to human XPO7 (exportin 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14.5 (RPKM 28.1), liver E14 (RPKM 26.2) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Xpo7 in Genome Data Viewer
    Location:
    14 D2; 14 36.44 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70899566..71004075, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70662126..70770864, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37085 Neighboring gene predicted gene, 38605 Neighboring gene fibroblast growth factor 17 Neighboring gene predicted gene, 52133 Neighboring gene nucleophosmin/nucleoplasmin 2 Neighboring gene STARR-seq mESC enhancer starr_37090 Neighboring gene PCNA-associated factor pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7334 Neighboring gene STARR-seq mESC enhancer starr_37093 Neighboring gene docking protein 2 Neighboring gene predicted gene, 34442 Neighboring gene predicted gene, 34500

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Clone Names

    • mKIAA0745

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity  
    enables nuclear export signal receptor activity  
    enables nuclear export signal receptor activity  
    enables protein binding PubMed 
    enables small GTPase binding PubMed 
    Process Evidence Code Pubs
    involved_in intracellular protein transport  
    involved_in nuclear export  
    acts_upstream_of_or_within nucleocytoplasmic transport PubMed 
    involved_in protein export from nucleus  
    involved_in protein export from nucleus  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    part_of nuclear pore  
    part_of nuclear pore  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    exportin-7
    Names
    RAN binding protein 16
    ran-binding protein 16

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359888.1NP_001346817.1  exportin-7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AA051428, AI431041, AK036837, AK039776, AK143729
      Consensus CDS
      CCDS88710.1
      UniProtKB/TrEMBL
      A0A2I3BQV5, E9PUW7
      Related
      ENSMUSP00000154350.2, ENSMUST00000228346.2
      Conserved Domains (2) summary
      smart00913
      Location:3197
      IBN_N; Importin-beta N-terminal domain
      COG5101
      Location:30306
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    2. NM_023045.3NP_075532.1  exportin-7 isoform 2

      See identical proteins and their annotated locations for NP_075532.1

      Status: VALIDATED

      Source sequence(s)
      AA051428, AC125180, AI431041, AK036837, AK039776, AK164595, CA325231
      Consensus CDS
      CCDS36974.1
      UniProtKB/Swiss-Prot
      Q3TP94, Q80TS9, Q8BSK5, Q8C9M7, Q8CB42, Q8CBL8, Q8CEF5, Q9EPK7
      UniProtKB/TrEMBL
      E9PUW7
      Related
      ENSMUSP00000022696.7, ENSMUST00000022696.8
      Conserved Domains (2) summary
      smart00913
      Location:3096
      IBN_N; Importin-beta N-terminal domain
      COG5101
      Location:29305
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      70899566..71004075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247914.2XP_030103774.1  exportin-7 isoform X2

      UniProtKB/TrEMBL
      E9PUW7
      Related
      ENSMUSP00000153855.2, ENSMUST00000226448.2
      Conserved Domains (2) summary
      smart00913
      Location:3096
      IBN_N; Importin-beta N-terminal domain
      COG5101
      Location:29314
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    2. XM_006519359.4XP_006519422.1  exportin-7 isoform X1

      UniProtKB/TrEMBL
      E9PUW7
      Conserved Domains (2) summary
      smart00913
      Location:3197
      IBN_N; Importin-beta N-terminal domain
      COG5101
      Location:30315
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    3. XM_011245132.4XP_011243434.1  exportin-7 isoform X3

      UniProtKB/TrEMBL
      E9PUW7
      Conserved Domains (1) summary
      pfam03810
      Location:448
      IBN_N; Importin-beta N-terminal domain
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