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    Plekhb2 pleckstrin homology domain containing, family B (evectins) member 2 [ Mus musculus (house mouse) ]

    Gene ID: 226971, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plekhb2provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family B (evectins) member 2provided by MGI
    Primary source
    MGI:MGI:2385825
    See related
    Ensembl:ENSMUSG00000026123 AllianceGenome:MGI:2385825
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Evt2; Phdc; evt-2; 2310009M15Rik
    Summary
    Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in regulation of cell differentiation. Predicted to be located in recycling endosome membrane. Predicted to be active in membrane. Is expressed in gut. Orthologous to human PLEKHB2 (pleckstrin homology domain containing B2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in colon adult (RPKM 50.2), large intestine adult (RPKM 42.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plekhb2 in Genome Data Viewer
    Location:
    1 B; 1 13.34 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (34889040..34918666)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (34849959..34879585)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:34859246-34859433 Neighboring gene small integral membrane protein 39 Neighboring gene family with sequence similarity 168, member B Neighboring gene STARR-seq mESC enhancer starr_00587 Neighboring gene STARR-positive B cell enhancer mm9_chr1:34924123-34924424 Neighboring gene uncharacterized protein C19orf29 homolog Neighboring gene STARR-seq mESC enhancer starr_00589 Neighboring gene STARR-seq mESC enhancer starr_00590 Neighboring gene charged multivesicular body protein 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evectins: vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes. Krappa R, et al. Proc Natl Acad Sci U S A, 1999 Apr 13. PMID 10200314, Free PMC Article
    2. Gene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung disease. Chatterjee S, et al. Proc Natl Acad Sci U S A, 2019 Dec 26. PMID 31818953, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family B member 2
    Names
    PH domain-containing family B member 2
    evectin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357425.1 → NP_001344354.1  pleckstrin homology domain-containing family B member 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC107738
      Consensus CDS
      CCDS14874.1
      UniProtKB/Swiss-Prot
      Q3UDH6, Q8C4I4, Q8CA27, Q9QZC7
      Conserved Domains (2) summary
      cd13265
      Location:1 → 108
      PH_evt; Evectin Pleckstrin homology (PH) domain
      pfam11029
      Location:127 → 188
      DAZAP2; DAZ associated protein 2 (DAZAP2)

    2. NM_145516.2 → NP_663491.1  pleckstrin homology domain-containing family B member 2 isoform 1

      See identical proteins and their annotated locations for NP_663491.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AK039771, AK149868, AV382273, CK625615
      Consensus CDS
      CCDS14874.1
      UniProtKB/Swiss-Prot
      Q3UDH6, Q8C4I4, Q8CA27, Q9QZC7
      Related
      ENSMUSP00000027297.5, ENSMUST00000027297.11
      Conserved Domains (2) summary
      cd13265
      Location:1 → 108
      PH_evt; Evectin Pleckstrin homology (PH) domain
      pfam11029
      Location:127 → 188
      DAZAP2; DAZ associated protein 2 (DAZAP2)

    3. NM_175421.1 → NP_780630.1  pleckstrin homology domain-containing family B member 2 isoform 2

      See identical proteins and their annotated locations for NP_780630.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC107738
      Consensus CDS
      CCDS78558.1
      UniProtKB/TrEMBL
      Q3UFC9
      Related
      ENSMUSP00000140475.2, ENSMUST00000156687.8
      Conserved Domains (2) summary
      cd13265
      Location:1 → 108
      PH_evt; Evectin Pleckstrin homology (PH) domain
      pfam00169
      Location:4 → 100
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      34889040..34918666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495898.3 → XP_006495961.1  pleckstrin homology domain-containing family B member 2 isoform X1

      See identical proteins and their annotated locations for XP_006495961.1

      UniProtKB/Swiss-Prot
      Q3UDH6, Q8C4I4, Q8CA27, Q9QZC7
      Conserved Domains (2) summary
      cd13265
      Location:1 → 108
      PH_evt; Evectin Pleckstrin homology (PH) domain
      pfam11029
      Location:127 → 188
      DAZAP2; DAZ associated protein 2 (DAZAP2)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZC7.1 GenPept UniProtKB/Swiss-Prot:Q9QZC7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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