Agxt2 alanine-glyoxylate aminotransferase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Agxt2provided by MGI
Official Full Name: alanine-glyoxylate aminotransferase 2provided by MGI
Primary source: MGI:MGI:2146052
See related: Ensembl:ENSMUSG00000089678 AllianceGenome:MGI:2146052
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables (R)-3-amino-2-methylpropionate-pyruvate transaminase activity and beta-alanine:pyruvate transaminase activity. Predicted to be involved in carboxylic acid metabolic process and positive regulation of nitric oxide biosynthetic process. Is active in mitochondrion. Is expressed in alimentary system and liver. Human ortholog(s) of this gene implicated in artery disease (multiple); atrial fibrillation; cerebral infarction; congestive heart failure; and mild cognitive impairment. Orthologous to human AGXT2 (alanine--glyoxylate aminotransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 21.6), kidney adult (RPKM 19.3) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 5.35 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (10358602..10410244)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (10358516..10410158)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DMGV Is a Rheostat of T Cell Survival and a Potential Therapeutic for Inflammatory Diseases and Cancers.
Title: DMGV Is a Rheostat of T Cell Survival and a Potential Therapeutic for Inflammatory Diseases and Cancers.
Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling.
Title: Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling.
this study shows that diabetes-linked transcription factor HNF4alpha regulates maminotransferase 2etabolism of endogenous methylarginines and beta-aminoisobutyric acid by controlling expression of alanine-glyoxylate
Title: Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2.
we experimentally proved the presence of a new pathway of homoarginine catabolism - its transamination by AGXT2 with formation of GOCA and demonstrated that endogenous AGXT2 is required for maintenance of homoarginine levels in mice.
Title: A Novel Pathway for Metabolism of the Cardiovascular Risk Factor Homoarginine by alanine:glyoxylate aminotransferase 2.
In this work, we describe an assay for the AGXT2 activity in mouse liver and kidney tissue. The overall production rates of DMGV-d(6) in mice were 195.37 pmol/min/mg total protein in liver and 85.21 pmol/min/mg total protein in kidney tissue.
Title: Probing AGXT2 enzyme activity in mouse tissue by applying stable isotope-labeled asymmetric dimethyl arginine as substrate.
Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure.
Title: Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Agxt2 (e-PCR), detects polymorphism
- UniSTS:546639

AI663818 (e-PCR)
- UniSTS:186019

AI303810 (e-PCR)
- UniSTS:160438

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables (R)-3-amino-2-methylpropionate-pyruvate transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables (R)-3-amino-2-methylpropionate-pyruvate transaminase activity	ISO Inferred from Sequence Orthology more info
enables alanine-glyoxylate transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alanine-glyoxylate transaminase activity	ISO Inferred from Sequence Orthology more info
enables alanine-glyoxylate transaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables beta-alanine:pyruvate transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-alanine:pyruvate transaminase activity	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-alanine catabolic process, by transamination	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-alanine catabolic process, by transamination	ISO Inferred from Sequence Orthology more info
involved_in N(omega),N(omega)-dimethyl-L-arginine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in N(omega),N(omega)-dimethyl-L-arginine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycine biosynthetic process, by transamination of glyoxylate	ISO Inferred from Sequence Orthology more info
involved_in glyoxylate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glyoxylate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alanine--glyoxylate aminotransferase 2, mitochondrial

Names: (R)-3-amino-2-methylpropionate--pyruvate transaminase; AGT 2; D-3-aminoisobutyrate-pyruvate aminotransferase; D-AIBAT; D-beta-aminoisobutyrate-pyruvate aminotransferase; beta-ALAAT II; beta-alanine-pyruvate aminotransferase

NP_001027021.1

EC 2.6.1.18

EC 2.6.1.40

EC 2.6.1.44

NP_001297664.1

EC 2.6.1.18

EC 2.6.1.40

EC 2.6.1.44

NP_001297665.1

EC 2.6.1.18

EC 2.6.1.40

EC 2.6.1.44

XP_006520132.1

EC 2.6.1.18

EC 2.6.1.40

EC 2.6.1.44

XP_006520133.1

EC 2.6.1.18

EC 2.6.1.40

EC 2.6.1.44

XP_036015326.1

EC 2.6.1.18

EC 2.6.1.40

EC 2.6.1.44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031851.1 → NP_001027021.1 alanine--glyoxylate aminotransferase 2, mitochondrial isoform 3

See identical proteins and their annotated locations for NP_001027021.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses alternate, in-frame donor and acceptor splice sites in the mid-coding region compared to variant 1. The resulting isoform (3) is longer containing an internal protein segment not found in isoform 1.

Source sequence(s)

AC087113

Consensus CDS

CCDS27378.1

UniProtKB/TrEMBL

H7BWY3

Related

ENSMUSP00000022858.8, ENSMUST00000022858.8

Conserved Domains (2) summary

cd00610
Location:66 → 532

OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...

COG0160
Location:54 → 532

GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]
NM_001310735.1 → NP_001297664.1 alanine--glyoxylate aminotransferase 2, mitochondrial isoform 1

See identical proteins and their annotated locations for NP_001297664.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.

Source sequence(s)

AI098750, AK149538

Consensus CDS

CCDS79362.1

UniProtKB/Swiss-Prot

B9EIZ8, Q3UEG6

Related

ENSMUSP00000106171.2, ENSMUST00000110542.8

Conserved Domains (2) summary

cd00610
Location:66 → 504

OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...

COG0160
Location:54 → 504

GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]
NM_001310736.1 → NP_001297665.1 alanine--glyoxylate aminotransferase 2, mitochondrial isoform 2

See identical proteins and their annotated locations for NP_001297665.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site in the 5' coding region compared to variant 1. The resulting isoform (2) is 1 aa shorter than isoform 1.

Source sequence(s)

AI098750, AK149538, BC145576

UniProtKB/TrEMBL

B7ZP16

Conserved Domains (2) summary

cd00610
Location:65 → 503

OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...

COG0160
Location:53 → 503

GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

10358602..10410244

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520069.4 → XP_006520132.1 alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1

Conserved Domains (1) summary

cd00610
Location:66 → 464

OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...
XM_006520070.4 → XP_006520133.1 alanine--glyoxylate aminotransferase 2, mitochondrial isoform X3

Conserved Domains (1) summary

cd00610
Location:19 → 298

OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...
XM_036159433.1 → XP_036015326.1 alanine--glyoxylate aminotransferase 2, mitochondrial isoform X2

Conserved Domains (1) summary

cd00610
Location:1 → 360

OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...