U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cwf19l1 CWF19 like cell cycle control factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 72502, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cwf19l1provided by MGI
    Official Full Name
    CWF19 like cell cycle control factor 1provided by MGI
    Primary source
    MGI:MGI:1919752
    See related
    Ensembl:ENSMUSG00000025200 AllianceGenome:MGI:1919752
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable RNA lariat debranching enzyme activator activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of post-mRNA release spliceosomal complex. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 17. Orthologous to human CWF19L1 (CWF19 like cell cycle control factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 3.0), CNS E18 (RPKM 3.0) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cwf19l1 in Genome Data Viewer
    Location:
    19 C3; 19 36.72 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44097076..44124324, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44108637..44135876, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ER lipid raft associated 1 Neighboring gene uracil DNA glycosylase pseudogene Neighboring gene conserved helix-loop-helix ubiquitous kinase Neighboring gene STARR-positive B cell enhancer ABC_E11678 Neighboring gene STARR-seq mESC enhancer starr_46219 Neighboring gene predicted gene, 24336 Neighboring gene predicted gene, 52383 Neighboring gene STARR-seq mESC enhancer starr_46220 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 2 Neighboring gene polycystic kidney disease 2-like 1 Neighboring gene stearoyl-coenzyme A desaturase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • 2610528C06Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA lariat debranching enzyme activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of post-mRNA release spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    CWF19-like protein 1
    Names
    CWF19-like 1, cell cycle control

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081077.1NP_001074546.1  CWF19-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001074546.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1)
      Source sequence(s)
      AC125101
      Consensus CDS
      CCDS37995.1
      UniProtKB/Swiss-Prot
      E9QNL3, Q05CB7, Q3UT85, Q8C2J2, Q8CI33
      Related
      ENSMUSP00000026218.6, ENSMUST00000026218.7
      Conserved Domains (3) summary
      cd07380
      Location:9229
      MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain
      pfam04676
      Location:446534
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:327422
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
    2. NM_001356578.1NP_001343507.1  CWF19-like protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' structure, resulting in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC125101
      Conserved Domains (3) summary
      cd07380
      Location:991
      MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain
      pfam04676
      Location:304396
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:189284
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      44097076..44124324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527364.3XP_006527427.1  CWF19-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006527427.1

      UniProtKB/Swiss-Prot
      Q8CI33
      Conserved Domains (3) summary
      cd07380
      Location:991
      MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain
      pfam04676
      Location:304396
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:189284
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
    2. XM_030251084.1XP_030106944.1  CWF19-like protein 1 isoform X2

      Conserved Domains (2) summary
      pfam04676
      Location:197289
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:82177
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
    3. XM_036161696.1XP_036017589.1  CWF19-like protein 1 isoform X2

      Conserved Domains (2) summary
      pfam04676
      Location:197289
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:82177
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
    4. XM_011247358.3XP_011245660.1  CWF19-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011245660.1

      UniProtKB/Swiss-Prot
      Q8CI33
      Conserved Domains (3) summary
      cd07380
      Location:991
      MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain
      pfam04676
      Location:304396
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:189284
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
    5. XM_030251083.2XP_030106943.1  CWF19-like protein 1 isoform X1

      Conserved Domains (3) summary
      cd07380
      Location:991
      MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain
      pfam04676
      Location:304396
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:189284
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
    6. XM_017318296.2XP_017173785.1  CWF19-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8CI33
      Related
      ENSMUST00000237067.2
      Conserved Domains (3) summary
      cd07380
      Location:991
      MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain
      pfam04676
      Location:304396
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:189284
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
    7. XM_036161695.1XP_036017588.1  CWF19-like protein 1 isoform X1

      Conserved Domains (3) summary
      cd07380
      Location:991
      MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain
      pfam04676
      Location:304396
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:189284
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
    8. XM_017318297.2XP_017173786.1  CWF19-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8CI33
      Conserved Domains (3) summary
      cd07380
      Location:991
      MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain
      pfam04676
      Location:304396
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:189284
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
    9. XM_036161698.1XP_036017591.1  CWF19-like protein 1 isoform X2

      Conserved Domains (2) summary
      pfam04676
      Location:197289
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:82177
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
    10. XM_030251087.2XP_030106947.1  CWF19-like protein 1 isoform X2

      Conserved Domains (2) summary
      pfam04676
      Location:197289
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:82177
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
    11. XM_030251086.2XP_030106946.1  CWF19-like protein 1 isoform X2

      Conserved Domains (2) summary
      pfam04676
      Location:197289
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:82177
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
    12. XM_030251085.2XP_030106945.1  CWF19-like protein 1 isoform X2

      Conserved Domains (2) summary
      pfam04676
      Location:197289
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:82177
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
    13. XM_036161697.1XP_036017590.1  CWF19-like protein 1 isoform X2

      Conserved Domains (2) summary
      pfam04676
      Location:197289
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:82177
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
    14. XM_011247357.2XP_011245659.1  CWF19-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011245659.1

      UniProtKB/Swiss-Prot
      Q8CI33
      Conserved Domains (3) summary
      cd07380
      Location:991
      MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain
      pfam04676
      Location:304396
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:189284
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...