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    Pld5 phospholipase D family member 5 [ Mus musculus (house mouse) ]

    Gene ID: 319455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pld5provided by MGI
    Official Full Name
    phospholipase D family member 5provided by MGI
    Primary source
    MGI:MGI:2442056
    See related
    Ensembl:ENSMUSG00000055214 AllianceGenome:MGI:2442056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B230365F16Rik
    Summary
    Predicted to enable catalytic activity. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human PLD5 (phospholipase D family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 5.0), whole brain E14.5 (RPKM 0.7) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pld5 in Genome Data Viewer
    Location:
    1 H4; 1 81.9 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (175789867..176109078, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (175962301..176281512, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23805 Neighboring gene exonuclease 1 Neighboring gene STARR-seq mESC enhancer starr_03104 Neighboring gene beclin 2 Neighboring gene STARR-seq mESC enhancer starr_03106 Neighboring gene RNA binding motif protein 8A2 Neighboring gene STARR-seq mESC enhancer starr_03107 Neighboring gene STARR-seq mESC enhancer starr_03109 Neighboring gene STARR-seq mESC enhancer starr_03110 Neighboring gene predicted gene, 46173 Neighboring gene predicted gene, 17965 Neighboring gene predicted gene, 36536

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development. López-Juárez A, et al. Glia, 2011 Apr. PMID 21319224, Free PMC Article
    2. Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Adissu HA, et al. Dis Model Mech, 2014 May. PMID 24652767, Free PMC Article
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inactive phospholipase D5
    Names
    inactive PLD 5
    inactive choline phosphatase 5
    inactive phosphatidylcholine-hydrolyzing phospholipase D5
    phospholipase D5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195816.1 → NP_001182745.1  inactive phospholipase D5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC124684, AC153644, AK136851, AK136888, BU609501, CK626039
      Consensus CDS
      CCDS56660.1
      UniProtKB/TrEMBL
      D3YYN6
      Related
      ENSMUSP00000106797.2, ENSMUST00000111167.2
      Conserved Domains (3) summary
      cd09146
      Location:49 → 211
      PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
      cd09149
      Location:247 → 440
      PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
      PHA02820
      Location:42 → 445
      PHA02820; phospholipase-D-like protein; Provisional

    2. NM_001357844.1 → NP_001344773.1  inactive phospholipase D5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124463, AC124684, AC147236, AC153644
      Conserved Domains (2) summary
      cd09146
      Location:19 → 181
      PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
      cd09149
      Location:217 → 410
      PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5

    3. NM_001357845.1 → NP_001344774.1  inactive phospholipase D5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124463, AC124684, AC147236, AC153644
      Conserved Domains (2) summary
      cd09146
      Location:19 → 181
      PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
      cd09149
      Location:217 → 410
      PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5

    4. NM_001357846.1 → NP_001344775.1  inactive phospholipase D5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153644, AK136888
      Conserved Domains (2) summary
      cd09149
      Location:101 → 294
      PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
      cl15239
      Location:1 → 65
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    5. NM_001357847.1 → NP_001344776.1  inactive phospholipase D5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC124463, AC124684, AC147236, AC153644
      Conserved Domains (2) summary
      cd09149
      Location:101 → 294
      PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
      cl15239
      Location:1 → 65
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    6. NM_176916.4 → NP_795890.2  inactive phospholipase D5 isoform 1

      See identical proteins and their annotated locations for NP_795890.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC124684, AC153644, AK136888, BU609501
      Consensus CDS
      CCDS15552.1
      UniProtKB/Swiss-Prot
      Q3UNN8, Q3UVW3, Q497Q7
      Related
      ENSMUSP00000069326.8, ENSMUST00000065967.14
      Conserved Domains (3) summary
      cd09146
      Location:111 → 273
      PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
      cd09149
      Location:309 → 502
      PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
      PHA02820
      Location:104 → 507
      PHA02820; phospholipase-D-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      175789867..176109078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496897.4 → XP_006496960.1  inactive phospholipase D5 isoform X1

      Conserved Domains (2) summary
      cd09149
      Location:258 → 451
      PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
      cl15239
      Location:111 → 222
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    2. XM_006496900.5 → XP_006496963.1  inactive phospholipase D5 isoform X7

      See identical proteins and their annotated locations for XP_006496963.1

      UniProtKB/Swiss-Prot
      Q3UNN8
      Conserved Domains (2) summary
      cd09149
      Location:101 → 294
      PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
      cl15239
      Location:1 → 65
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    3. XM_030254909.1 → XP_030110769.1  inactive phospholipase D5 isoform X7

      Conserved Domains (2) summary
      cd09149
      Location:101 → 294
      PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
      cl15239
      Location:1 → 65
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    4. XM_030254898.2 → XP_030110758.1  inactive phospholipase D5 isoform X3

      Conserved Domains (2) summary
      cd09146
      Location:19 → 181
      PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
      cd09149
      Location:217 → 410
      PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5

    5. XM_030254896.2 → XP_030110756.1  inactive phospholipase D5 isoform X2

      Conserved Domains (2) summary
      cd09146
      Location:20 → 182
      PLDc_vPLD5_1; Putative catalytic domain, repeat 1, of inactive veterbrate phospholipase PLD5
      cd09149
      Location:218 → 411
      PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5

    6. XM_036165683.1 → XP_036021576.1  inactive phospholipase D5 isoform X7

      Conserved Domains (2) summary
      cd09149
      Location:101 → 294
      PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
      cl15239
      Location:1 → 65
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    7. XM_030254901.2 → XP_030110761.1  inactive phospholipase D5 isoform X4

      Conserved Domains (2) summary
      cd09149
      Location:166 → 359
      PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
      cl15239
      Location:19 → 130
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    8. XM_006496898.5 → XP_006496961.1  inactive phospholipase D5 isoform X5

      Conserved Domains (2) summary
      cd09149
      Location:146 → 339
      PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
      cl15239
      Location:3 → 110
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    9. XM_011238827.4 → XP_011237129.1  inactive phospholipase D5 isoform X6

      Conserved Domains (2) summary
      cd09149
      Location:111 → 304
      PLDc_vPLD5_2; Putative catalytic domain, repeat 2, of inactive veterbrate phospholipase PLD5
      cl15239
      Location:4 → 75
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UNN8.1 GenPept UniProtKB/Swiss-Prot:Q3UNN8

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