U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Derl1 Der1-like domain family, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 67819, updated on 9-Dec-2024

    Summary

    Official Symbol
    Derl1provided by MGI
    Official Full Name
    Der1-like domain family, member 1provided by MGI
    Primary source
    MGI:MGI:1915069
    See related
    Ensembl:ENSMUSG00000022365 AllianceGenome:MGI:1915069
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Derlin-1; 1110021N07Rik
    Summary
    Predicted to enable several functions, including enzyme binding activity; identical protein binding activity; and signal recognition particle binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Acts upstream of or within cellular response to unfolded protein. Located in early endosome; endoplasmic reticulum quality control compartment; and late endosome. Is expressed in embryo; gut; pancreas epithelium; yolk sac; and yolk sac endoderm. Orthologous to human DERL1 (derlin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 131.2), mammary gland adult (RPKM 73.3) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Derl1 in Genome Data Viewer
    Location:
    15 D1; 15 24.06 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (57732898..57755814, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (57869502..57892418, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4133 Neighboring gene predicted gene, 35682 Neighboring gene predicted gene, 35771 Neighboring gene STARR-positive B cell enhancer ABC_E9418 Neighboring gene predicted gene 16006 Neighboring gene zinc fingers and homeoboxes 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:57624620-57624846 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:57670229-57670416 Neighboring gene STARR-positive B cell enhancer ABC_E2441 Neighboring gene STARR-seq mESC enhancer starr_38745 Neighboring gene STARR-positive B cell enhancer ABC_E1905 Neighboring gene STARR-positive B cell enhancer ABC_E7368 Neighboring gene TBC1 domain family, member 31 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:57804514-57804715 Neighboring gene STARR-positive B cell enhancer ABC_E5478 Neighboring gene nuclear encoded tRNA methionine 16 (anticodon CAT) Neighboring gene predicted gene, 57624

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables MHC class I protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MHC class I protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signal recognition particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signal recognition particle binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signal recognition particle binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-specific protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to misfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to misfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to unfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum unfolded protein response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to unfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde protein transport, ER to cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Derlin-1 retrotranslocation complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Derlin-1 retrotranslocation complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Derlin-1-VIMP complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Derlin-1-VIMP complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum quality control compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    derlin-1
    Names
    degradation in endoplasmic reticulum protein 1
    der1-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024207.4NP_077169.1  derlin-1

      See identical proteins and their annotated locations for NP_077169.1

      Status: PROVISIONAL

      Source sequence(s)
      AC154874
      Consensus CDS
      CCDS27484.1
      UniProtKB/Swiss-Prot
      Q3U6Z2, Q99J56, Q9D918
      UniProtKB/TrEMBL
      Q3UGB8
      Related
      ENSMUSP00000022993.6, ENSMUST00000022993.7
      Conserved Domains (1) summary
      pfam04511
      Location:11204
      DER1; Der1-like family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      57732898..57755814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)