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    Unc5cl unc-5 family C-terminal like [ Mus musculus (house mouse) ]

    Gene ID: 76589, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Unc5clprovided by MGI
    Official Full Name
    unc-5 family C-terminal likeprovided by MGI
    Primary source
    MGI:MGI:1923839
    See related
    Ensembl:ENSMUSG00000043592 AllianceGenome:MGI:1923839
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zud; 2510009H09Rik
    Summary
    Predicted to enable peptidase activity. Acts upstream of or within positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in membrane. Is expressed in central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human UNC5CL (unc-5 family C-terminal like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in duodenum adult (RPKM 18.8), small intestine adult (RPKM 18.4) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Unc5cl in Genome Data Viewer
    Location:
    17 C; 17 24.14 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48761155..48846737)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48454127..48539709)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42751 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48567545-48567654 Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 Neighboring gene VISTA enhancer mm243 Neighboring gene predicted gene, 30283 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48601436-48601659 Neighboring gene translocator protein 2 Neighboring gene STARR-seq mESC enhancer starr_42753 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48649023-48649224 Neighboring gene predicted gene, 30419 Neighboring gene predicted gene, 24071

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade.
      Title: The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade.
    2. Focuses on identification and characterization of human UNC5CL, but also identifies mouse Unc5cl.
      Title: Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables netrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in netrin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UNC5C-like protein
    Names
    ZU5 and death domain-containing inhibitor of NF-kB
    ZU5 and death domain-containing protein
    protein unc-5 homolog C-like
    unc-5 homolog C-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152823.4 → NP_690036.4  UNC5C-like protein

      See identical proteins and their annotated locations for NP_690036.4

      Status: VALIDATED

      Source sequence(s)
      AC165291
      Consensus CDS
      CCDS28870.1
      UniProtKB/Swiss-Prot
      Q3UMF8, Q501N0, Q6R653, Q8BTQ8, Q8BYF7, Q8C1L0, Q8K3C8
      UniProtKB/TrEMBL
      E9QLC2
      Related
      ENSMUSP00000074159.7, ENSMUST00000074574.13
      Conserved Domains (3) summary
      pfam00791
      Location:108 → 185
      ZU5; ZU5 domain
      pfam17217
      Location:243 → 346
      UPA; UPA domain
      cl14633
      Location:408 → 488
      DD; Death Domain Superfamily of protein-protein interaction domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      48761155..48846737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317717.2 → XP_017173206.1  UNC5C-like protein isoform X2

      UniProtKB/Swiss-Prot
      Q3UMF8, Q501N0, Q6R653, Q8BTQ8, Q8BYF7, Q8C1L0, Q8K3C8
      Conserved Domains (3) summary
      pfam00791
      Location:108 → 185
      ZU5; ZU5 domain
      pfam17217
      Location:243 → 346
      UPA; UPA domain
      cl14633
      Location:408 → 445
      DD; Death Domain Superfamily of protein-protein interaction domains

    2. XM_006525099.4 → XP_006525162.1  UNC5C-like protein isoform X1

      See identical proteins and their annotated locations for XP_006525162.1

      UniProtKB/Swiss-Prot
      Q3UMF8, Q501N0, Q6R653, Q8BTQ8, Q8BYF7, Q8C1L0, Q8K3C8
      UniProtKB/TrEMBL
      E9QLC2
      Conserved Domains (3) summary
      pfam00791
      Location:108 → 185
      ZU5; ZU5 domain
      pfam17217
      Location:243 → 346
      UPA; UPA domain
      cl14633
      Location:408 → 488
      DD; Death Domain Superfamily of protein-protein interaction domains

    3. XM_006525101.4 → XP_006525164.1  UNC5C-like protein isoform X3

      UniProtKB/Swiss-Prot
      Q3UMF8, Q501N0, Q6R653, Q8BTQ8, Q8BYF7, Q8C1L0, Q8K3C8
      Conserved Domains (3) summary
      pfam00791
      Location:108 → 185
      ZU5; ZU5 domain
      pfam17217
      Location:243 → 346
      UPA; UPA domain
      cl14633
      Location:408 → 445
      DD; Death Domain Superfamily of protein-protein interaction domains

    4. XM_006525102.4 → XP_006525165.1  UNC5C-like protein isoform X4

      See identical proteins and their annotated locations for XP_006525165.1

      Conserved Domains (2) summary
      pfam00791
      Location:108 → 185
      ZU5; ZU5 domain
      pfam17217
      Location:243 → 346
      UPA; UPA domain

    5. XM_006525104.4 → XP_006525167.1  UNC5C-like protein isoform X4

      See identical proteins and their annotated locations for XP_006525167.1

      Conserved Domains (2) summary
      pfam00791
      Location:108 → 185
      ZU5; ZU5 domain
      pfam17217
      Location:243 → 346
      UPA; UPA domain

    RNA

    1. XR_876580.3 RNA Sequence

    2. XR_876582.3 RNA Sequence

    3. XR_876583.3 RNA Sequence

    4. XR_385383.4 RNA Sequence

    5. XR_876584.3 RNA Sequence

    6. XR_003952210.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6R653.2 GenPept UniProtKB/Swiss-Prot:Q6R653

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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