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    Xkr7 X-linked Kx blood group related 7 [ Mus musculus (house mouse) ]

    Gene ID: 228787, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Xkr7provided by MGI
    Official Full Name
    X-linked Kx blood group related 7provided by MGI
    Primary source
    MGI:MGI:3526711
    See related
    Ensembl:ENSMUSG00000042631 AllianceGenome:MGI:3526711
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in apoptotic process involved in development; engulfment of apoptotic cell; and phosphatidylserine exposure on apoptotic cell surface. Is active in plasma membrane. Orthologous to human XKR7 (XK related 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 4.3), CNS E18 (RPKM 3.2) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Xkr7 in Genome Data Viewer
    Location:
    2 H1; 2 75.41 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152873772..152902214)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (153031852..153060294)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene tubulin tyrosine ligase-like family, member 9 Neighboring gene predicted gene 14199 Neighboring gene STARR-positive B cell enhancer mm9_chr2:152840956-152841257 Neighboring gene p53 and DNA damage regulated 1 Neighboring gene predicted gene, 32286 Neighboring gene cerebral cavernous malformation 2-like Neighboring gene hemopoietic cell kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exposure of phosphatidylserine by Xk-related protein family members during apoptosis. Suzuki J, et al. J Biol Chem, 2014 Oct 31. PMID 25231987, Free PMC Article
    2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process involved in development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in engulfment of apoptotic cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylserine exposure on apoptotic cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    XK-related protein 7
    Names
    X Kell blood group precursor related family member 7 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011732.1 → NP_001011732.1  XK-related protein 7

      See identical proteins and their annotated locations for NP_001011732.1

      Status: PROVISIONAL

      Source sequence(s)
      AY534253
      Consensus CDS
      CCDS16905.1
      UniProtKB/Swiss-Prot
      A2ATH3, Q5GH64
      Related
      ENSMUSP00000049346.7, ENSMUST00000037235.7
      Conserved Domains (1) summary
      pfam09815
      Location:59 → 442
      XK-related; XK-related protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      152873772..152902214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250595.1 → XP_030106455.1  XK-related protein 7 isoform X3

      Conserved Domains (2) summary
      PHA02682
      Location:219 → 315
      PHA02682; ORF080 virion core protein; Provisional
      pfam09815
      Location:1 → 222
      XK-related; XK-related protein

    2. XM_006499323.4 → XP_006499386.1  XK-related protein 7 isoform X2

      Conserved Domains (2) summary
      PHA02682
      Location:246 → 372
      PHA02682; ORF080 virion core protein; Provisional
      pfam09815
      Location:2 → 249
      XK-related; XK-related protein

    3. XM_006499321.4 → XP_006499384.1  XK-related protein 7 isoform X1

      Conserved Domains (2) summary
      PHA02682
      Location:253 → 379
      PHA02682; ORF080 virion core protein; Provisional
      pfam09815
      Location:10 → 256
      XK-related; XK-related protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5GH64.1 GenPept UniProtKB/Swiss-Prot:Q5GH64

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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