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    Gstm7 glutathione S-transferase, mu 7 [ Mus musculus (house mouse) ]

    Gene ID: 68312, updated on 3-Dec-2024

    Summary

    Official Symbol
    Gstm7provided by MGI
    Official Full Name
    glutathione S-transferase, mu 7provided by MGI
    Primary source
    MGI:MGI:1915562
    See related
    Ensembl:ENSMUSG00000004035 AllianceGenome:MGI:1915562
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd203c; 0610005A07Rik
    Summary
    Predicted to enable several functions, including anion binding activity; glutathione peroxidase activity; and glutathione transferase activity. Predicted to be involved in several processes, including cellular detoxification of nitrogen compound; long-chain fatty acid metabolic process; and regulation of release of sequestered calcium ion into cytosol. Predicted to be located in cytosol; intercellular bridge; and sarcoplasmic reticulum. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and sensory organ. Orthologous to human GSTM2 (glutathione S-transferase mu 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 289.7), liver adult (RPKM 39.7) and 8 other tissues See more
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    Genomic context

    See Gstm7 in Genome Data Viewer
    Location:
    3 F2.3; 3 46.83 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107833650..107839193, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107926334..107931877, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933431E20 gene Neighboring gene glutathione S-transferase, mu 5 Neighboring gene predicted gene 9515 Neighboring gene glutathione S-transferase, mu 6 Neighboring gene glutathione S-transferase, mu 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fatty acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutathione binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular detoxification of nitrogen compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular detoxification of nitrogen compound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to caffeine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to caffeine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hepoxilin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hepoxilin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in linoleic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in linoleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nitrobenzene metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nitrobenzene metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutathione S-transferase Mu 7
    Names
    GST class-mu 7
    NP_001343280.1
    NP_080948.2
    XP_006502034.1
    XP_006502036.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356351.2NP_001343280.1  glutathione S-transferase Mu 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC079042
      Consensus CDS
      CCDS89676.1
      UniProtKB/TrEMBL
      D3YVP5
      Related
      ENSMUSP00000102299.2, ENSMUST00000106688.8
      Conserved Domains (2) summary
      cd03209
      Location:88208
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:980
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    2. NM_001429089.1NP_001416018.1  glutathione S-transferase Mu 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC079042
    3. NM_001429090.1NP_001416019.1  glutathione S-transferase Mu 7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC079042
      UniProtKB/TrEMBL
      D3YVP6
    4. NM_026672.4NP_080948.2  glutathione S-transferase Mu 7 isoform 1

      See identical proteins and their annotated locations for NP_080948.2

      Status: VALIDATED

      Source sequence(s)
      AC079042
      Consensus CDS
      CCDS38595.1
      UniProtKB/Swiss-Prot
      Q3TRV7, Q3V4E2, Q80W21
      UniProtKB/TrEMBL
      D3YVP6
      Related
      ENSMUSP00000004137.4, ENSMUST00000004137.11
      Conserved Domains (2) summary
      cd03209
      Location:92212
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:384
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      107833650..107839193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501971.4XP_006502034.1  glutathione S-transferase Mu 7 isoform X1

      Conserved Domains (2) summary
      cd03209
      Location:99219
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:2091
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    2. XM_006501973.4XP_006502036.1  glutathione S-transferase Mu 7 isoform X2

      Conserved Domains (2) summary
      cd03209
      Location:82202
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:374
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...