SNI1 negative regulator of systemic acquired resistance (SNI1) [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SNI1
Official Full Name: negative regulator of systemic acquired resistance (SNI1)
Primary source: TAIR:AT4G18470
Locus tag: AT4G18470
See related: Araport:AT4G18470
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F28J12.3; F28J12_3; INDUCIBLE 1; SUPPRESSOR OF NPR1-1
Summary: Negative regulator of systemic acquired resistance (SAR), repressor of pathogenesis-related PR gene expression which is removed by NPR1 upon induction of SAR. Encodes leucine-rich nuclear protein. Conserved in plants, with putative orthologs found in several plant species. Many NPR1-dependent PR gene are specifically derepressed in the sni1 mutant. The structural similarity of SNI1 to Armadillo repeat proteins implies that SNI1 may form a scaffold for interaction with proteins that modulate transcription. Histone modification may be involved in SNI1-mediated repression of PR genes.
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Genomic context

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See SNI1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 15

Sequence:: Chromosome: 4; NC_003075.7 (10192909..10195662)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAD51 supports DMC1 by inhibiting the SMC5/6 complex during meiosis.
Title: RAD51 supports DMC1 by inhibiting the SMC5/6 complex during meiosis.
Natural variation identifies SNI1, the SMC5/6 component, as a modifier of meiotic crossover in Arabidopsis.
Title: Natural variation identifies SNI1, the SMC5/6 component, as a modifier of meiotic crossover in Arabidopsis.
Transfected Arabidopsis negative regulator of systemic acquired resistance (SNI1) protein inhibited DNA damage repair in human osteosarcoma U2OS cancer cells.
Title: Influence of Human p53 on Plant Development.
SNI1 (suppressor of npr1-1, inducible 1) and ASAP1 (Arabidopsis SNI1 Associated Protein 1) are the two missing subunits of the SMC5/6 complex required for controlling DNA damage. [SNI1]
Title: Salicylic acid activates DNA damage responses to potentiate plant immunity.
CBNAC and SNI1 are hypothesized to work together as repressor proteins in the cooperative suppression of plant basal defense.
Title: A NAC transcription factor and SNI1 cooperatively suppress basal pathogen resistance in Arabidopsis thaliana.
the configuration of two TGA binding sites within the PR-1 promoter determines whether NPR1 can induce and whether SNI1 can repress the promoter
Title: Exchanging the as-1-like element of the PR-1 promoter by the as-1 element of the CaMV 35S promoter abolishes salicylic acid responsiveness and regulation by NPR1 and SNI1.
analyzed the importance of the TGA-binding sites LS5 and LS7 and the WKRY box LS4 for regulation by NPR1 and SNI1
Title: The Arabidopsis PR-1 promoter contains multiple integration sites for the coactivator NPR1 and the repressor SNI1.
RAD51D and SNI1 have dual roles in pathogenesis-related gene transcription and DNA recombination
Title: Arabidopsis SNI1 and RAD51D regulate both gene transcription and DNA recombination during the defense response.
Results suggest that due to the structural similarity of SNI1 to Armadillo repeat proteins, SNI1 may form a scaffold for interaction with proteins that modulate transcription.
Title: A comprehensive structure-function analysis of Arabidopsis SNI1 defines essential regions and transcriptional repressor activity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_117959.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to nematode	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of defense response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of systemic acquired resistance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic cell DNA recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within systemic acquired resistance	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of Smc5-Smc6 complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: negative regulator of systemic acquired resistance (SNI1)

NP_567557.1

SUPPRESSOR OF NPR1-1, INDUCIBLE 1 (SNI1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).