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    HAC4 histone acetyltransferase of the CBP family 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842048, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HAC4
    Official Full Name
    histone acetyltransferase of the CBP family 4
    Primary source
    TAIR:AT1G55970
    Locus tag
    AT1G55970
    See related
    Araport:AT1G55970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA P300/CBP ACETYLTRANSFERASE-RELATED PROTEIN 2; ATHPCAT2; F14J16.27; F14J16_27; HAC02; HAC04; HAC6; HAG04; HAG4; histone acetyltransferase of the CBP family 4; HISTONE ACETYLTRANSFERASE OF THE CBP FAMILY 6; HISTONE ACETYLTRANSFERASE OF THE GNAT/MYST SUPERFAMILY 04; HISTONE ACETYLTRANSFERASE OF THE GNAT/MYST SUPERFAMILY 4
    Summary
    HAC4 is most likely to be an expressed pseudogene that lacks HAT function. there is a single nucleotide deletion in both the HAC4 genomic and cDNA sequences relative to its homologs. The resulting frameshift within the open reading frame causes a stop codon to occur within the predicted acetyltransferase catalytic domain.
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    Genomic context

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    See HAC4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    16
    Sequence:
    Chromosome: 1; NC_003070.9 (20932451..20938352, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein Neighboring gene miscRNA Neighboring gene FAD/NAD(P)-binding oxidoreductase family protein Neighboring gene glycine-rich protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes. Pandey R, et al. Nucleic Acids Res, 2002 Dec 1. PMID 12466527, Free PMC Article
    2. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001333753.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    histone acetyltransferase of the CBP family 4
    NP_001319247.1
    • histone acetyltransferase of the CBP family 4 (HAC4); FUNCTIONS IN: histone acetyltransferase activity; INVOLVED IN: regulation of transcription, DNA-dependent; LOCATED IN: nucleus, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, TAZ-type (InterPro:IPR000197), Histone H3-K56 acetyltransferase, RTT109 (InterPro:IPR013178), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, ZZ-type (InterPro:IPR000433), Zinc finger, PHD-finger (InterPro:IPR019787); BEST Arabidopsis thaliana protein match is: histone acetyltransferase of the CBP family 5 (TAIR:AT3G12980.1); Has 778 Blast hits to 575 proteins in 103 species: Archae - 0; Bacteria - 0; Metazoa - 394; Fungi - 19; Plants - 254; Viruses - 0; Other Eukaryotes - 111 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20932451..20938352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104475.3 → NP_564706.1  histone acetyltransferase of the CBP family 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564706.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I3I0, Q8LRK3, Q8LRK4, Q94EW2, Q9LG11, Q9SGS6
      UniProtKB/TrEMBL
      A0A1P8AQG0
      Conserved Domains (5) summary
      smart00551
      Location:417 → 495
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd15614
      Location:767 → 838
      PHD_HAC_like; PHD finger found in Arabidopsis thaliana histone acetyltransferases (HATs) HAC and similar proteins
      cl00295
      Location:1284 → 1325
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
      cl02120
      Location:898 → 1095
      HAT_KAT11; Histone acetylation protein
      cl02660
      Location:1359 → 1420
      zf-TAZ; TAZ zinc finger

    2. NM_001333753.1 → NP_001319247.1  histone acetyltransferase of the CBP family 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I3I0, Q8LRK3, Q8LRK4, Q94EW2, Q9LG11, Q9SGS6
    Nucleotide Protein
    Heading Accession and Version

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