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    ADPRH ADP-ribosylarginine hydrolase [ Homo sapiens (human) ]

    Gene ID: 141, updated on 3-Dec-2024

    Summary

    Official Symbol
    ADPRHprovided by HGNC
    Official Full Name
    ADP-ribosylarginine hydrolaseprovided by HGNC
    Primary source
    HGNC:HGNC:269
    See related
    Ensembl:ENSG00000144843 MIM:603081; AllianceGenome:HGNC:269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARH1; hARH1
    Summary
    The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014]
    Expression
    Ubiquitous expression in lung (RPKM 7.2), spleen (RPKM 6.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ADPRH in Genome Data Viewer
    Location:
    3q13.33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (119579492..119589945)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (122299217..122309670)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (119298339..119308792)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CD80 molecule Neighboring gene CSRP2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20305 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20306 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20308 Neighboring gene Sharpr-MPRA regulatory region 12076 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20311 Neighboring gene uncharacterized LOC107986118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:119287249-119287750 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:119297943-119298444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20314 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:119300593-119301792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20317 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:119319749-119320248 Neighboring gene phospholipase A1 member A Neighboring gene ReSE screen-validated silencer GRCh37_chr3:119331548-119331710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20318 Neighboring gene ribosomal protein L10 pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ADP-ribosylarginine hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ADP-ribosylarginine hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables potassium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein de-ADP-ribosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein modification process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ADP-ribosylarginine hydrolase
    Names
    ADP-ribose-L-arginine cleaving enzyme
    ADP-ribosylhydrolase ARH1
    [Protein ADP-ribosylarginine] hydrolase
    NP_001116.1
    NP_001278878.1
    NP_001278879.1
    NP_001358021.1
    NP_001378921.1
    XP_047303432.1
    XP_054201282.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001125.4NP_001116.1  ADP-ribosylarginine hydrolase isoform 1

      See identical proteins and their annotated locations for NP_001116.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein. Variants 1, 2 and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC073352, BC063883, BC074769
      Consensus CDS
      CCDS2990.1
      UniProtKB/Swiss-Prot
      B2R8H1, D3DN83, P54922
      UniProtKB/TrEMBL
      A8K6X2
      Related
      ENSP00000349496.3, ENST00000357003.8
      Conserved Domains (1) summary
      pfam03747
      Location:6323
      ADP_ribosyl_GH; ADP-ribosylglycohydrolase
    2. NM_001291949.2NP_001278878.1  ADP-ribosylarginine hydrolase isoform 1

      See identical proteins and their annotated locations for NP_001278878.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC073352, AK291787, BC063883, BC074769
      Consensus CDS
      CCDS2990.1
      UniProtKB/Swiss-Prot
      B2R8H1, D3DN83, P54922
      UniProtKB/TrEMBL
      A8K6X2
      Related
      ENSP00000417528.1, ENST00000478927.5
      Conserved Domains (1) summary
      pfam03747
      Location:6323
      ADP_ribosyl_GH; ADP-ribosylglycohydrolase
    3. NM_001291950.2NP_001278879.1  ADP-ribosylarginine hydrolase isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two exons, differs in the 5' UTR, and initiates translation at a downstream start codon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC073352, AK304560, BC063883
      UniProtKB/Swiss-Prot
      P54922
      UniProtKB/TrEMBL
      B4E341
      Conserved Domains (1) summary
      pfam03747
      Location:25216
      ADP_ribosyl_GH; ADP-ribosylglycohydrolase
    4. NM_001371092.1NP_001358021.1  ADP-ribosylarginine hydrolase isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs from variant 1 in the 5' UTR. Variants 1, 2 and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC073352
      Consensus CDS
      CCDS2990.1
      UniProtKB/Swiss-Prot
      B2R8H1, D3DN83, P54922
      UniProtKB/TrEMBL
      A8K6X2
      Conserved Domains (1) summary
      pfam03747
      Location:6323
      ADP_ribosyl_GH; ADP-ribosylglycohydrolase
    5. NM_001391992.1NP_001378921.1  ADP-ribosylarginine hydrolase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC073352
      Consensus CDS
      CCDS2990.1
      UniProtKB/Swiss-Prot
      B2R8H1, D3DN83, P54922
      UniProtKB/TrEMBL
      A8K6X2
      Related
      ENSP00000420200.1, ENST00000478399.5
      Conserved Domains (1) summary
      pfam03747
      Location:6323
      ADP_ribosyl_GH; ADP-ribosylglycohydrolase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      119579492..119589945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447476.1XP_047303432.1  ADP-ribosylarginine hydrolase isoform X1

      UniProtKB/Swiss-Prot
      B2R8H1, D3DN83, P54922
      UniProtKB/TrEMBL
      A8K6X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      122299217..122309670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345307.1XP_054201282.1  ADP-ribosylarginine hydrolase isoform X1

      UniProtKB/Swiss-Prot
      B2R8H1, D3DN83, P54922
      UniProtKB/TrEMBL
      A8K6X2