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    PAQR3 progestin and adipoQ receptor family member 3 [ Homo sapiens (human) ]

    Gene ID: 152559, updated on 3-Dec-2024

    Summary

    Official Symbol
    PAQR3provided by HGNC
    Official Full Name
    progestin and adipoQ receptor family member 3provided by HGNC
    Primary source
    HGNC:HGNC:30130
    See related
    Ensembl:ENSG00000163291 MIM:614577; AllianceGenome:HGNC:30130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RKTG
    Summary
    This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
    Expression
    Broad expression in testis (RPKM 20.7), brain (RPKM 8.5) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PAQR3 in Genome Data Viewer
    Location:
    4q21.21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (78887076..78939438, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (82222838..82275056, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (79833032..79860592, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:79696740-79697370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:79698003-79698633 Neighboring gene uncharacterized LOC124900722 Neighboring gene uncharacterized LOC105377299 Neighboring gene BMP2K divergent transcript Neighboring gene BMP2 inducible kinase Neighboring gene Sharpr-MPRA regulatory region 10702 Neighboring gene RNA, 7SL, cytoplasmic 127, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15515 Neighboring gene long intergenic non-protein coding RNA 1088 Neighboring gene uncharacterized LOC124900723 Neighboring gene MPRA-validated peak5059 silencer Neighboring gene N-alpha-acetyltransferase 11, NatA catalytic subunit Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:80169419-80169920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:80218690-80219258

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-membrane adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    progestin and adipoQ receptor family member 3
    Names
    Raf kinase trapping to Golgi
    progestin and adipoQ receptor family member III

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053104.1 RefSeqGene

      Range
      5001..32561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001040202.2NP_001035292.1  progestin and adipoQ receptor family member 3 isoform 1

      See identical proteins and their annotated locations for NP_001035292.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC093841, AY424281, BX648346, DA410845
      Consensus CDS
      CCDS34020.1
      UniProtKB/Swiss-Prot
      A8K5B7, B3KP59, Q6PIQ1, Q6TCH7, Q86X05, Q8NCP9
      UniProtKB/TrEMBL
      F8W784
      Related
      ENSP00000421981.1, ENST00000512733.5
      Conserved Domains (1) summary
      pfam03006
      Location:64283
      HlyIII; Haemolysin-III related
    2. NM_001350105.2NP_001337034.1  progestin and adipoQ receptor family member 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1. Both variants 2 and 3 encode the same protein.
      Source sequence(s)
      AC093841
      Conserved Domains (1) summary
      cl03831
      Location:1165
      HlyIII; Haemolysin-III related
    3. NM_001350106.2NP_001337035.1  progestin and adipoQ receptor family member 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1. Both variants 2 and 3 encode the same protein.
      Source sequence(s)
      AC093841
      Conserved Domains (1) summary
      cl03831
      Location:1165
      HlyIII; Haemolysin-III related

    RNA

    1. NR_146462.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC093841
    2. NR_146463.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC093841
    3. NR_146464.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC093841
    4. NR_146465.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC093841

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      78887076..78939438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449645.1XP_047305601.1  progestin and adipoQ receptor family member 3 isoform X4

    2. XM_005262769.6XP_005262826.1  progestin and adipoQ receptor family member 3 isoform X2

      See identical proteins and their annotated locations for XP_005262826.1

      UniProtKB/TrEMBL
      F8W784
      Related
      ENSP00000344203.6, ENST00000342820.10
      Conserved Domains (1) summary
      cl03831
      Location:64264
      HlyIII; Haemolysin-III related
    3. XM_024453910.2XP_024309678.1  progestin and adipoQ receptor family member 3 isoform X3

      Conserved Domains (1) summary
      cl03831
      Location:1165
      HlyIII; Haemolysin-III related
    4. XM_047449643.1XP_047305599.1  progestin and adipoQ receptor family member 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5B7, B3KP59, Q6PIQ1, Q6TCH7, Q86X05, Q8NCP9
      UniProtKB/TrEMBL
      F8W784
      Related
      ENSP00000425080.1, ENST00000511594.5

    RNA

    1. XR_938694.4 RNA Sequence

    2. XR_007096371.1 RNA Sequence

    3. XR_007096372.1 RNA Sequence

    4. XR_002959712.2 RNA Sequence

    5. XR_007096373.1 RNA Sequence

      Related
      ENST00000515853.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      82222838..82275056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348992.1XP_054204967.1  progestin and adipoQ receptor family member 3 isoform X4

    2. XM_054348991.1XP_054204966.1  progestin and adipoQ receptor family member 3 isoform X3

    3. XM_054348990.1XP_054204965.1  progestin and adipoQ receptor family member 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5B7, B3KP59, Q6PIQ1, Q6TCH7, Q86X05, Q8NCP9
      UniProtKB/TrEMBL
      F8W784

    RNA

    1. XR_008486927.1 RNA Sequence

    2. XR_008486926.1 RNA Sequence

    3. XR_008486925.1 RNA Sequence

    4. XR_008486928.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177453.2: Suppressed sequence

      Description
      NM_177453.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.