Tlr2 toll-like receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tlr2provided by RGD
Official Full Name: toll-like receptor 2provided by RGD
Primary source: RGD:735138
See related: EnsemblRapid:ENSRNOG00000009822 AllianceGenome:RGD:735138
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables lipopeptide binding activity. Involved in several processes, including central nervous system myelin formation; positive regulation of interleukin-10 production; and response to molecule of bacterial origin. Located in cell body; cell projection; and cell surface. Used to study carotid stenosis; ileitis; keratitis; lung disease (multiple); and renal fibrosis. Biomarker of acute necrotizing pancreatitis; kidney failure; lung disease; pancreatitis; and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 134.2), Spleen (RPKM 104.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (171499189..171504831, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (169200620..169206819, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (182840171..182846061, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chronic activation of Toll-like receptor 2 induces an ichthyotic skin phenotype.
Title: Chronic activation of Toll-like receptor 2 induces an ichthyotic skin phenotype.
Sodium butyrate alleviates LPS-induced kidney injury via inhibiting TLR2/4 to regulate rBD2 expression.
Title: Sodium butyrate alleviates LPS-induced kidney injury via inhibiting TLR2/4 to regulate rBD2 expression.
Toll-like receptor-2 mediates systemic inflammation in gentamicin-induced rat nephrotoxicity.
Title: Toll-like receptor-2 mediates systemic inflammation in gentamicin-induced rat nephrotoxicity.
TLR2- and TLR3-activated microglia induce different levels of neuronal network dysfunction in a context-dependent manner.
Title: TLR2- and TLR3-activated microglia induce different levels of neuronal network dysfunction in a context-dependent manner.
Toll-like receptor 2 signaling deficiency in cardiac cells ameliorates Ang II-induced cardiac inflammation and remodeling.
Title: Toll-like receptor 2 signaling deficiency in cardiac cells ameliorates Ang II-induced cardiac inflammation and remodeling.
Toll-Like Receptor 2 Attenuates Traumatic Brain Injury-Induced Neural Stem Cell Proliferation in Dentate Gyrus of Rats.
Title: Toll-Like Receptor 2 Attenuates Traumatic Brain Injury-Induced Neural Stem Cell Proliferation in Dentate Gyrus of Rats.
Ischemic postconditioning attenuates the inflammatory response in ischemia/reperfusion myocardium by upregulating miR499 and inhibiting TLR2 activation.
Title: Ischemic postconditioning attenuates the inflammatory response in ischemia/reperfusion myocardium by upregulating miR‑499 and inhibiting TLR2 activation.
this study provided evidence that Dex could alleviate isoflurane-induced neurotoxicity through inhibition of the TLR2/NF-kappaB signaling pathway. The findings may offer novel insights for the clinical usage of anesthetics.
Title: Dexmedetomidine pretreatment attenuates isoflurane-induced neurotoxicity via inhibiting the TLR2/NF-κB signaling pathway in neonatal rats.
TLR2/4 mediated adipose inflammation plays a key role in renin-angiotensin system activation induced by uric acid in adipose tissue.
Title: TLR2 and TLR4 mediate an activation of adipose tissue renin-angiotensin system induced by uric acid.
this study reveals that pFTY720 depends on S1PR3 to protect astrocytes against OGD-induced neuroinflammation, due to inhibiting TLR2/4-PI3K-NFkappaB signalling pathway.
Title: S1PR3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen-glucose deprivation-induced neuroinflammation via inhibiting TLR2/4-NFκB signalling.

Submit: New GeneRIF Correction See all GeneRIFs (96)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Toll-like receptor binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables diacyl lipopeptide binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipopeptide binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables lipoteichoic acid binding	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	ISO Inferred from Sequence Orthology more info
enables peptidoglycan binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables triacyl lipopeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables triacyl lipopeptide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in I-kappaB phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within MyD88-dependent toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell surface pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to diacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to diacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lipoteichoic acid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipoteichoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to peptidoglycan	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to triacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to triacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in central nervous system myelin formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within detection of diacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of triacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
involved_in immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in leukotriene metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in microglia development	ISO Inferred from Sequence Orthology more info
involved_in microglial cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of neutrophil migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular response to macrophage colony-stimulating factor stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-10 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-18 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of leukocyte migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of matrix metallopeptidase secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neutrophil migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of xenophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of dendritic cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in response to bacterial lipoprotein	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fatty acid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to molecule of fungal origin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to peptidoglycan	ISO Inferred from Sequence Orthology more info
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in toll-like receptor 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor TLR6:TLR2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in toll-like receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of xenophagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of Toll-like receptor 1-Toll-like receptor 2 protein complex	ISO Inferred from Sequence Orthology more info
part_of Toll-like receptor 2-Toll-like receptor 6 protein complex	ISO Inferred from Sequence Orthology more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: toll-like receptor 2

NP_942064.1

EC 3.2.2.6

XP_008759324.3

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198769.2 → NP_942064.1 toll-like receptor 2 precursor

See identical proteins and their annotated locations for NP_942064.1

Status: PROVISIONAL

Source sequence(s)

AY151255

UniProtKB/TrEMBL

A0A8K0ZGH5, A6J5V7, E9PTD9, Q6YGU2

Related

ENSRNOP00000095767.1, ENSRNOT00000097289.2

Conserved Domains (6) summary

PRK15370
Location:340 → 558

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00031
Location:54 → 77

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:362 → 388

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

171499189..171504831 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008761102.4 → XP_008759324.3 toll-like receptor 2 isoform X1

UniProtKB/TrEMBL

E9PTD9

Related

ENSRNOP00000103742.1, ENSRNOT00000167617.1

Conserved Domains (6) summary

PRK15370
Location:387 → 605

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00082
Location:580 → 633

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:687 → 831

TIR; Toll - interleukin 1 - resistance

sd00031
Location:101 → 124

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:409 → 435

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:124 → 182

LRR_8; Leucine rich repeat