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    Tmem65 transmembrane protein 65 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500874, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem65provided by RGD
    Official Full Name
    transmembrane protein 65provided by RGD
    Primary source
    RGD:1563224
    See related
    EnsemblRapid:ENSRNOG00000008934 AllianceGenome:RGD:1563224
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563224
    Summary
    Predicted to be involved in cardiac conduction; cardiac ventricle development; and regulation of cardiac conduction. Predicted to be located in intercalated disc; mitochondrial inner membrane; and plasma membrane. Predicted to be active in mitochondrion. Orthologous to human TMEM65 (transmembrane protein 65). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 516.2), Muscle (RPKM 387.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem65 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (92163632..92268430, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (90336997..90378930, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (98668589..98709613, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene fer-1-like family member 6 Neighboring gene uncharacterized LOC134479914 Neighboring gene uncharacterized LOC120093661 Neighboring gene uncharacterized LOC103690428 Neighboring gene developmental pluripotency associated 3 like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A mutation in the TMEM65 gene results in mitochondrial myopathy with severe neurological manifestations. Nazli A, et al. Eur J Hum Genet, 2017 Jun. PMID 28295037, Free PMC Article
    2. TMEM65 is a mitochondrial inner-membrane protein. Nishimura N, et al. PeerJ, 2014. PMID 24765583, Free PMC Article
    3. Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Sharma P, et al. Nat Commun, 2015 Sep 25. PMID 26403541
    4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiac ventricle development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiac ventricle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cardiac conduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 65

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100995.1 → NP_001094465.1  transmembrane protein 65

      See identical proteins and their annotated locations for NP_001094465.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129127
      UniProtKB/TrEMBL
      A1L1L9, A6HRK7
      Related
      ENSRNOP00000093575.1, ENSRNOT00000107015.2
      Conserved Domains (1) summary
      pfam10507
      Location:141 → 248
      DUF2453; Protein of unknown function (DUF2453)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      92163632..92268430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264121.1 → XP_063120191.1  transmembrane protein 65 isoform X2

    2. XM_063264123.1 → XP_063120193.1  transmembrane protein 65 isoform X4

    3. XM_039079755.2 → XP_038935683.1  transmembrane protein 65 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AVM0, A6HRK7
      Related
      ENSRNOP00000097891.1, ENSRNOT00000113387.2
      Conserved Domains (1) summary
      pfam10507
      Location:114 → 221
      TMEM65; Transmembrane protein 65

    4. XM_063264122.1 → XP_063120192.1  transmembrane protein 65 isoform X3

    RNA

    1. XR_005486706.2 RNA Sequence

    2. XR_005486707.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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