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    Panx2 pannexin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362979, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Panx2provided by RGD
    Official Full Name
    pannexin 2provided by RGD
    Primary source
    RGD:735191
    See related
    EnsemblRapid:ENSRNOG00000055530 AllianceGenome:RGD:735191
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables gap junction channel activity. Involved in cell-cell signaling. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human PANX2 (pannexin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 50.3), Kidney (RPKM 21.3) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Panx2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (122018937..122032009)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (120139259..120153056)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (130042948..130053034)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479953 Neighboring gene modulator of VRAC current 1 Neighboring gene Mov10 like RNA helicase 1 Neighboring gene uncharacterized LOC120093824 Neighboring gene TraB domain containing Neighboring gene selenoprotein O Neighboring gene tubulin gamma complex component 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of pannexin2 protein in healthy and ischemized brain of adult rats. Zappalà A, et al. Neuroscience, 2007 Sep 7. PMID 17692470
    2. Pannexin protein expression in the rat middle cerebral artery. Burns AR, et al. J Vasc Res, 2012. PMID 22301733, Free PMC Article
    3. Pannexin-2-deficiency sensitizes pancreatic β-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo. Berchtold LA, et al. Mol Cell Endocrinol, 2017 Jun 15. PMID 28390953
    4. Expression and roles of pannexins in ATP release in the pituitary gland. Li S, et al. Endocrinology, 2011 Jun. PMID 21467198, Free PMC Article
    5. Pannexins in ischemia-induced neurodegeneration. Bargiotas P, et al. Proc Natl Acad Sci U S A, 2011 Dec 20. PMID 22147915, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Panx2 is an important regulator of the insulin secretory capacity and apoptosis in pancreatic beta-cells.
      Title: Pannexin-2-deficiency sensitizes pancreatic β-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo.
    2. pannexin 2 is expressed in both endothelium and smooth muscle of middle cerebral arteries.
      Title: Pannexin protein expression in the rat middle cerebral artery.
    3. Overexpression of pannexins 1 and 2 in pituitary cells enhanced the release of ATP.
      Title: Expression and roles of pannexins in ATP release in the pituitary gland.
    4. Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other
      Title: Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other.
    5. Results show that pannexins 1, 2, and 3 are abundantly expressed in the mouse and rat cochlea and demonstrate distinct cellular distributions.
      Title: Identification and characterization of pannexin expression in the mammalian cochlea.
    6. We noted the expression of Px2 in astrocytes of reactive gliosis in the hippocampus after I/R injury. Px2 mediates the formation of hemichannels for the release of signaling molecules devoted to influence the cellular metabolism .
      Title: Expression of pannexin2 protein in healthy and ischemized brain of adult rats.
    7. Panx1 and Panx2 are abundantly expressed in the retina, and may therefore contribute to the electrical and metabolic coupling, or to signaling between retinal neurons
      Title: Expression of pannexin family of proteins in the retina.
    8. the different expression patterns of pannexin 1 (Panx1) and pannexin 2 (Panx2) in the brain indicate that pannexins form cell type-specific gap junctions with distinct properties that may subserve different functions.
      Title: Pannexins, a family of gap junction proteins expressed in brain.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables gap junction channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT enables gap junction hemi-channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-containing complex binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables structural molecule activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables wide pore channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic cation transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interleukin-1 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to ischemia ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pannexin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199409.2 → NP_955441.2  pannexin-2

      See identical proteins and their annotated locations for NP_955441.2

      Status: VALIDATED

      Source sequence(s)
      AJ557016, BC112319, BQ204587
      UniProtKB/Swiss-Prot
      P60571
      UniProtKB/TrEMBL
      A6K7I7
      Conserved Domains (2) summary
      PRK11633
      Location:400 → 469
      PRK11633; cell division protein DedD; Provisional
      cl03000
      Location:58 → 150
      Innexin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      122018937..122032009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079619.2 → XP_038935547.1  pannexin-2 isoform X1

      UniProtKB/TrEMBL
      A6K7I7
      Related
      ENSRNOP00000069647.3, ENSRNOT00000089707.3
      Conserved Domains (1) summary
      cl03000
      Location:58 → 150
      Innexin

    2. XM_039079620.2 → XP_038935548.1  pannexin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A329, A6K7I7
      Related
      ENSRNOP00000085314.1, ENSRNOT00000111032.2
      Conserved Domains (2) summary
      PRK11633
      Location:400 → 469
      PRK11633; cell division protein DedD; Provisional
      cl03000
      Location:58 → 150
      Innexin

    3. XM_039079622.2 → XP_038935550.1  pannexin-2 isoform X3

      UniProtKB/TrEMBL
      R9PXY9

    4. XM_039079621.2 → XP_038935549.1  pannexin-2 isoform X3

      UniProtKB/TrEMBL
      R9PXY9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60571.2 GenPept UniProtKB/Swiss-Prot:P60571

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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