Kcnj9 potassium inwardly-rectifying channel, subfamily J, member 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnj9provided by RGD
Official Full Name: potassium inwardly-rectifying channel, subfamily J, member 9provided by RGD
Primary source: RGD:621440
See related: AllianceGenome:RGD:621440
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Girk3; Kir3.3
Summary: Enables PDZ domain binding activity. Predicted to be involved in potassium ion import across plasma membrane; regulation of monoatomic ion transmembrane transport; and regulation of presynaptic membrane potential. Predicted to be part of monoatomic ion channel complex. Predicted to be active in parallel fiber to Purkinje cell synapse and presynaptic membrane. Orthologous to human KCNJ9 (potassium inwardly rectifying channel subfamily J member 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 117.0), Testes (RPKM 21.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (87313191..87320293, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (84780826..84787928, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (90703046..90710148, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a decisive role for the neuronal K(+) channel in regulating NCAM-dependent neurite outgrowth and attribute a physiologically meaningful role to the functional interplay of Kir3.3, NCAM, and TrkB in ontogeny
Title: Functional consequences of the interactions among the neural cell adhesion molecule NCAM, the receptor tyrosine kinase TrkB, and the inwardly rectifying K+ channel KIR3.3.
The Kir3.3 subunit protein is expressed in raphe-derived axons at the light and electron microscopic level.
Title: Expression of Kir3.3 potassium channel subunits in supraependymal axons.
Data describe localization of GIRK1, GIRK2, and GIRK3 subunits and 5-HT(1A) receptor in rat brain, and their co-expression with markers of glutamatergic, gamma-aminobutyric acid (GABA)ergic, cholinergic, and serotonergic neurons.
Title: Distribution and neurochemical characterization of neurons expressing GIRK channels in the rat brain.

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General gene information

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Markers

G42052 (e-PCR)
- UniSTS:105077

Kcnj9 (e-PCR), detects polymorphism
- UniSTS:260575

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein activated inward rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in parallel fiber to Purkinje cell synapse	IEA Inferred from Electronic Annotation more info
is_active_in parallel fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G protein-activated inward rectifier potassium channel 3

Names: GIRK-3; inward rectifier K(+) channel Kir3.3; inwardly rectifier K(+) channel Kir3.3; potassium channel, inwardly rectifying subfamily J member 9; potassium voltage-gated channel subfamily J member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053834.2 → NP_446286.1 G protein-activated inward rectifier potassium channel 3

See identical proteins and their annotated locations for NP_446286.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q63511

UniProtKB/TrEMBL

A0A0G2JZD9, A6JG51

Conserved Domains (2) summary

pfam01007
Location:25 → 164

IRK; Inward rectifier potassium channel

pfam17655
Location:171 → 334

IRK_C; Inward rectifier potassium channel C-terminal domain