Dock2 dedicator of cytokinesis 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Dock2provided by RGD
Full Name: dedicator of cytokinesis 2provided by RGD
Primary source: RGD:1564189
See related: EnsemblRapid:ENSRNOG00000006932 AllianceGenome:RGD:1564189
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AABR07029272.1
Summary: Predicted to enable GTPase activator activity; T cell receptor binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in macropinocytosis; myeloid dendritic cell activation involved in immune response; and positive regulation of phagocytosis. Predicted to act upstream of or within several processes, including T cell activation; immunological synapse formation; and membrane raft polarization. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in immunodeficiency 40. Orthologous to human DOCK2 (dedicator of cytokinesis 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 457.3), Thymus (RPKM 455.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 55

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (19331412..19748987, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (18827237..19244832, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (19181512..19603171, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DOCK2 silencing gene therapy effectively attenuates neointimal hyperplasia in vein grafts. Knock-down of DOCK2 would be a potential therapeutic approach for the treatment of vein graft failure.
Title: Dedicator of cytokinesis 2 silencing therapy inhibits neointima formation and improves blood flow in rat vein grafts.
Identify DOCK2 as a novel regulator for smooth muscle cell phenotypic modulation and vascular lesion formation after vascular injury.
Title: Dedicator of cytokinesis 2, a novel regulator for smooth muscle phenotypic modulation and vascular remodeling.

Submit: New GeneRIF Correction

General gene information

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Markers

RH143987 (e-PCR)
- UniSTS:233233

d10rat118 (e-PCR)
- UniSTS:120640

RH138702 (e-PCR)
- UniSTS:220789

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables T cell receptor binding	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within alpha-beta T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of T cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immunological synapse formation	ISO Inferred from Sequence Orthology more info
involved_in macropinocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within membrane raft polarization	ISO Inferred from Sequence Orthology more info
involved_in myeloid dendritic cell activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in myoblast fusion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative thymic T cell selection	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive thymic T cell selection	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dedicator of cytokinesis protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034001.2 → NP_001029173.1 dedicator of cytokinesis protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I5ZX73, Q3MIE5

Related

ENSRNOP00000087663.1, ENSRNOT00000118123.2
NM_001419946.1 → NP_001406875.1 dedicator of cytokinesis protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I5ZRT6

Related

ENSRNOP00000081338.1, ENSRNOT00000116913.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

19331412..19748987 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039087140.2 → XP_038943068.1 dedicator of cytokinesis protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZX73

Conserved Domains (3) summary

pfam16172
Location:71 → 414

DOCK_N; DOCK N-terminus

cl14603
Location:422 → 617

C2; C2 domain

cl17036
Location:12 → 67

SH3; Src Homology 3 domain superfamily
XM_039087142.2 → XP_038943070.1 dedicator of cytokinesis protein 2 isoform X2

UniProtKB/TrEMBL

A0A8I5ZX73

Conserved Domains (3) summary

pfam16172
Location:71 → 414

DOCK_N; DOCK N-terminus

cl14603
Location:422 → 617

C2; C2 domain

cl17036
Location:12 → 67

SH3; Src Homology 3 domain superfamily