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    TDT tonoplast dicarboxylate transporter [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834806, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TDT
    Official Full Name
    tonoplast dicarboxylate transporter
    Primary source
    TAIR:AT5G47560
    Locus tag
    AT5G47560
    See related
    Araport:AT5G47560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSDAT; ATTDT; tonoplast dicarboxylate transporter; TONOPLAST DICARBOXYLATE TRANSPORTER
    Summary
    Encodes a tonoplast malate/fumarate transporter.
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    Genomic context

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    See TDT in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (19287369..19291103, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Auxin-responsive family protein Neighboring gene Mo25 family protein Neighboring gene Cystatin/monellin superfamily protein Neighboring gene NADH dehydrogenase ubiquinone 1 beta subcomplex subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall. Pizzi M, et al. Hum Pathol, 2018 Nov. PMID 29969607
    2. Purification and functional characterization of the vacuolar malate transporter tDT from Arabidopsis. Frei B, et al. J Biol Chem, 2018 Mar 16. PMID 29367340, Free PMC Article
    3. Impaired Malate and Fumarate Accumulation Due to the Mutation of the Tonoplast Dicarboxylate Transporter Has Little Effects on Stomatal Behavior. Medeiros DB, et al. Plant Physiol, 2017 Nov. PMID 28899959, Free PMC Article
    4. Impaired pH homeostasis in Arabidopsis lacking the vacuolar dicarboxylate transporter and analysis of carboxylic acid transport across the tonoplast. Hurth MA, et al. Plant Physiol, 2005 Mar. PMID 15728336, Free PMC Article
    5. The plant homolog to the human sodium/dicarboxylic cotransporter is the vacuolar malate carrier. Emmerlich V, et al. Proc Natl Acad Sci U S A, 2003 Sep 16. PMID 12947042, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Small subsets of TdT-positive cells are a normal finding in the lymph nodes of both pediatric and adult patients, and their occurrence does not apparently correlate with any clinical-pathological parameter.
      Title: Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall.
    2. tDT from Arabidopsis is the first member of the well-known and widely present SLC13 group of carrier proteins, exhibiting an antiport mode of transport
      Title: Purification and functional characterization of the vacuolar malate transporter tDT from Arabidopsis.
    3. manipulation of the tonoplastic organic acid transporter impacted mitochondrial metabolism, while the overall stomatal and photosynthetic capacity were unaffected.
      Title: Impaired Malate and Fumarate Accumulation Due to the Mutation of the Tonoplast Dicarboxylate Transporter Has Little Effects on Stomatal Behavior.
    4. AttDT is critical for regulation of pH homeostasis under certain conditions. [AttDT] [tonoplast dicarboxylate transporter]
      Title: Impaired pH homeostasis in Arabidopsis lacking the vacuolar dicarboxylate transporter and analysis of carboxylic acid transport across the tonoplast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_124129.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables malate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables malate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within malate transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of intracellular pH TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tonoplast dicarboxylate transporter
    NP_199567.1
    • tonoplast dicarboxylate transporter (TDT); CONTAINS InterPro DOMAIN/s: Sodium/sulphate symporter (InterPro:IPR001898); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19287369..19291103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124129.4 → NP_199567.1  tonoplast dicarboxylate transporter [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199567.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LG88, Q9FEH9, Q9FGK1, Q9MAW4
      UniProtKB/TrEMBL
      A0A178UJ16
      Conserved Domains (2) summary
      COG0471
      Location:74 → 529
      CitT; Di- and tricarboxylate transporter [Carbohydrate transport and metabolism]
      cd01115
      Location:76 → 534
      SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LG88.2

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