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    Cpvl carboxypeptidase, vitellogenic-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502774, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cpvlprovided by RGD
    Official Full Name
    carboxypeptidase, vitellogenic-likeprovided by RGD
    Primary source
    RGD:1563609
    See related
    EnsemblRapid:ENSRNOG00000009172 AllianceGenome:RGD:1563609
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type carboxypeptidase activity. Predicted to be involved in proteolysis. Orthologous to human CPVL (carboxypeptidase vitellogenic like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 39.1), Testes (RPKM 14.1) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cpvl in Genome Data Viewer
    Location:
    4q24
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (84311853..84422098, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (82981421..83091730, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (84026851..84137172, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene TLR4 interactor with leucine-rich repeats Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120102282 Neighboring gene chimerin 2 Neighboring gene uncharacterized LOC102553678

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114536

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable serine carboxypeptidase CPVL
    NP_001025098.1
    XP_006236573.2
    XP_008761137.1
    XP_038964175.1
    XP_038964177.1
    XP_038964178.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029927.1 → NP_001025098.1  probable serine carboxypeptidase CPVL precursor

      See identical proteins and their annotated locations for NP_001025098.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097471
      UniProtKB/Swiss-Prot
      Q4QR71
      UniProtKB/TrEMBL
      A0A8L2R2T7, A6K0U2
      Related
      ENSRNOP00000012196.6, ENSRNOT00000012196.7
      Conserved Domains (1) summary
      pfam00450
      Location:74 → 468
      Peptidase_S10; Serine carboxypeptidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      84311853..84422098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108247.2 → XP_038964175.1  probable serine carboxypeptidase CPVL isoform X2

      UniProtKB/Swiss-Prot
      Q4QR71
      UniProtKB/TrEMBL
      A0A8L2R2T7, A6K0U2
      Conserved Domains (1) summary
      pfam00450
      Location:74 → 468
      Peptidase_S10; Serine carboxypeptidase

    2. XM_008762915.4 → XP_008761137.1  probable serine carboxypeptidase CPVL isoform X2

      See identical proteins and their annotated locations for XP_008761137.1

      UniProtKB/Swiss-Prot
      Q4QR71
      UniProtKB/TrEMBL
      A0A8L2R2T7, A6K0U2
      Conserved Domains (1) summary
      pfam00450
      Location:74 → 468
      Peptidase_S10; Serine carboxypeptidase

    3. XM_006236511.5 → XP_006236573.2  probable serine carboxypeptidase CPVL isoform X1

      UniProtKB/TrEMBL
      A0A8L2R2T7, A6K0U2
      Related
      ENSRNOP00000107506.1, ENSRNOT00000144804.1
      Conserved Domains (2) summary
      COG2939
      Location:48 → 478
      Kex1; Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]
      pfam00450
      Location:80 → 474
      Peptidase_S10; Serine carboxypeptidase

    4. XM_039108249.2 → XP_038964177.1  probable serine carboxypeptidase CPVL isoform X3

      Conserved Domains (1) summary
      cl08270
      Location:15 → 334
      Peptidase_S10; Serine carboxypeptidase

    5. XM_039108250.2 → XP_038964178.1  probable serine carboxypeptidase CPVL isoform X4

      Conserved Domains (1) summary
      cl08270
      Location:4 → 288
      Peptidase_S10; Serine carboxypeptidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4QR71.1 GenPept UniProtKB/Swiss-Prot:Q4QR71

    Gene LinkOut

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