Irak3 interleukin-1 receptor-associated kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Irak3provided by RGD
Official Full Name: interleukin-1 receptor-associated kinase 3provided by RGD
Primary source: RGD:1308846
See related: EnsemblRapid:ENSRNOG00000004226 AllianceGenome:RGD:1308846
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and protein dimerization activity. Predicted to be involved in several processes, including regulation of cytokine production; regulation of innate immune response; and response to bacterium. Predicted to act upstream of or within positive regulation of NF-kappaB transcription factor activity and protein autophosphorylation. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IRAK3 (interleukin 1 receptor associated kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 64.3), Heart (RPKM 58.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (57538522..57600166, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (55653949..55714371, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (64922830..64982224, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-539-5p inhibits the inflammatory injury in septic H9c2 cells by regulating IRAK3.
Title: MiR-539-5p inhibits the inflammatory injury in septic H9c2 cells by regulating IRAK3.
Differential gene expression of interleukin-1 receptor associated kinase-1 and interleukin-1 receptor associated kinase-M in peripheral blood mononuclear cells of young and aged rats following preconditioning with endotoxin.
Title: Differential gene expression of interleukin-1 receptor associated kinase-1 and interleukin-1 receptor associated kinase-M in peripheral blood mononuclear cells of young and aged rats following preconditioning with endotoxin.

Submit: New GeneRIF Correction

General gene information

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Markers

RH141464 (e-PCR)
- UniSTS:223458

RH133525 (e-PCR)
- UniSTS:216808

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Toll signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-1-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipopolysaccharide-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex disassembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage tolerance induction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein-containing complex disassembly	ISO Inferred from Sequence Orthology more info
involved_in response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to peptidoglycan	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-1 receptor-associated kinase 3

NP_001101571.1

EC 2.7.11.1

XP_017450343.1

EC 2.7.11.1

XP_038935060.1

EC 2.7.11.1

XP_038935061.1

EC 2.7.11.1

XP_038935062.1

EC 2.7.11.1

XP_038935063.1

EC 2.7.11.1

XP_038935064.1

EC 2.7.11.1

XP_063119570.1

EC 2.7.11.1

XP_063119571.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108101.1 → NP_001101571.1 interleukin-1 receptor-associated kinase 3

See identical proteins and their annotated locations for NP_001101571.1

Status: PROVISIONAL

Source sequence(s)

CH473960

UniProtKB/TrEMBL

B2RYC8, F6QZN4

Related

ENSRNOP00000005686.3, ENSRNOT00000005686.6

Conserved Domains (3) summary

cd08796
Location:15 → 102

Death_IRAK-M; Death domain of Interleukin 1 Receptor Associated Kinase-M

cd14160
Location:185 → 460

PK_IRAK3; Pseudokinase domain of Interleukin-1 Receptor Associated Kinase 3

pfam00069
Location:179 → 455

Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

57538522..57600166 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079133.2 → XP_038935061.1 interleukin-1 receptor-associated kinase 3 isoform X3

Conserved Domains (1) summary

cd14160
Location:46 → 321

PK_IRAK3; Pseudokinase domain of Interleukin-1 Receptor Associated Kinase 3
XM_017594854.3 → XP_017450343.1 interleukin-1 receptor-associated kinase 3 isoform X1
XM_039079132.2 → XP_038935060.1 interleukin-1 receptor-associated kinase 3 isoform X2

Conserved Domains (1) summary

cd14160
Location:52 → 327

PK_IRAK3; Pseudokinase domain of Interleukin-1 Receptor Associated Kinase 3
XM_039079134.2 → XP_038935062.1 interleukin-1 receptor-associated kinase 3 isoform X4

Conserved Domains (1) summary

cl21453
Location:12 → 265

PKc_like; Protein Kinases, catalytic domain
XM_063263501.1 → XP_063119571.1 interleukin-1 receptor-associated kinase 3 isoform X6
XM_039079135.2 → XP_038935063.1 interleukin-1 receptor-associated kinase 3 isoform X6

Conserved Domains (1) summary

cl21453
Location:2 → 213

PKc_like; Protein Kinases, catalytic domain
XM_063263500.1 → XP_063119570.1 interleukin-1 receptor-associated kinase 3 isoform X5
XM_039079136.2 → XP_038935064.1 interleukin-1 receptor-associated kinase 3 isoform X7

Conserved Domains (2) summary

cd08796
Location:15 → 102

Death_IRAK-M; Death domain of Interleukin 1 Receptor Associated Kinase-M

cl21453
Location:185 → 309

PKc_like; Protein Kinases, catalytic domain