Klra22 killer cell lectin-like receptor subfamily A, member 22 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klra22provided by RGD
Official Full Name: killer cell lectin-like receptor subfamily A, member 22provided by RGD
Primary source: RGD:3023
See related: EnsemblRapid:ENSRNOG00000053772 AllianceGenome:RGD:3023
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ly49; Klra1; Ly49s2
Summary: Predicted to enable signaling receptor activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 44.2), Thymus (RPKM 4.6) and 1 other tissue See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4q42

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (165721602..165743025, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (164036378..164057805, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (164384701..164406096, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The distal upstream promoter in Ly49 genes, Pro1, is active in mature NK cells and T cells, does not require TATA boxes, and displays enhancer activity
Title: The distal upstream promoter in Ly49 genes, Pro1, is active in mature NK cells and T cells, does not require TATA boxes, and displays enhancer activity.
L. monocytogenes infection may have multiple effects on NK cells in vivo, and Ly49-expressing NK cells may be involved in the immune responses towards L. monocytogenes
Title: Listeria monocytogenes infection affects a subset of Ly49-expressing NK cells in the rat.
molecular cloning and gene mapping
Title: The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex.
Ly-49 stimulatory receptor 3 (Ly-49s3)is a promiscuous activating rat NK cell receptor for nonclassical MHC class I (RT1-C/E/M)-encoded target ligands.
Title: Ly-49s3 is a promiscuous activating rat NK cell receptor for nonclassical MHC class I-encoded target ligands.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: killer cell lectin-like receptor subfamily A, member 22

Names: Ly49 stimulatory receptor 2; Lymphocye antigen 49 complex

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173291.2 → NP_775413.2 killer cell lectin-like receptor subfamily A, member 22

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A0G2JXE9, Q5MPW6, Q62978

Related

ENSRNOP00000071779.2, ENSRNOT00000080017.3

Conserved Domains (2) summary

cd03593
Location:143 → 258

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:38 → 156

Ly49; Ly49-like protein, N-terminal region