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    Jmjd7 jumonji domain containing 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100137086, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jmjd7provided by RGD
    Official Full Name
    jumonji domain containing 7provided by RGD
    Primary source
    RGD:2290039
    See related
    EnsemblRapid:ENSRNOG00000050072 AllianceGenome:RGD:2290039
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including methylated histone binding activity; peptidase activity; and peptidyl-lysine 3-dioxygenase activity. Predicted to be involved in protein hydroxylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human JMJD7 (jumonji domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 106.9), Heart (RPKM 79.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Jmjd7 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (127452238..127458326)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (106998454..107004538)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (111818150..111824211)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene MAX dimerization protein MGA Neighboring gene mitogen activated protein kinase binding protein 1 Neighboring gene phospholipase A2 group IVB Neighboring gene spectrin, beta, non-erythrocytic 5 Neighboring gene EH-domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Clipping of arginine-methylated histone tails by JMJD5 and JMJD7. Liu H, et al. Proc Natl Acad Sci U S A, 2017 Sep 12. PMID 28847961, Free PMC Article
    2. The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. Markolovic S, et al. Nat Chem Biol, 2018 Jul. PMID 29915238, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyl-lysine 3-dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein hydroxylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7
    Names
    jmjC domain-containing protein 7
    NP_001108128.1
    XP_063139009.1
    XP_063139010.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114656.1 → NP_001108128.1  bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D3ZZV5
      Related
      ENSRNOP00000063762.1, ENSRNOT00000067181.3
      Conserved Domains (1) summary
      pfam13621
      Location:38 → 297
      Cupin_8; Cupin-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      127452238..127458326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282939.1 → XP_063139009.1  bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 isoform X1

    2. XM_063282940.1 → XP_063139010.1  bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 isoform X2

    RNA

    1. XR_005501743.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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