Atad2 ATPase family, AAA domain containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atad2provided by RGD
Official Full Name: ATPase family, AAA domain containing 2provided by RGD
Primary source: RGD:1304849
See related: EnsemblRapid:ENSRNOG00000025604 AllianceGenome:RGD:1304849
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATP hydrolysis activity; chromatin binding activity; and histone binding activity. Predicted to be involved in chromatin remodeling and positive regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human ATAD2 (ATPase family AAA domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 206.0), Spleen (RPKM 178.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q33

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (91523626..91566238, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (89634123..89676738, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (97984754..98027379)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in nucleosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation-coupled chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATPase family AAA domain-containing protein 2

NP_001128351.1

EC 3.6.1.3

XP_038935135.1

EC 3.6.1.3

XP_038935137.1

EC 3.6.1.3

XP_038935138.1

EC 3.6.1.3

XP_063119629.1

EC 3.6.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134879.1 → NP_001128351.1 ATPase family AAA domain-containing protein 2

See identical proteins and their annotated locations for NP_001128351.1

Status: PROVISIONAL

Source sequence(s)

CH473950

UniProtKB/TrEMBL

A0A8I5ZNS1, A6HRJ6, D3ZJD2

Related

ENSRNOP00000079642.1, ENSRNOT00000112469.2

Conserved Domains (3) summary

cd05528
Location:972 → 1082

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

smart00382
Location:444 → 585

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:449 → 583

AAA; ATPase family associated with various cellular activities (AAA)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

91523626..91566238 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079207.2 → XP_038935135.1 ATPase family AAA domain-containing protein 2 isoform X1

UniProtKB/TrEMBL

D3ZJD2

Related

ENSRNOP00000111379.1, ENSRNOT00000123197.1

Conserved Domains (3) summary

cd05528
Location:919 → 1029

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

COG0464
Location:377 → 866

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

cd19517
Location:359 → 528

RecA-like_Yta7-like; ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains
XM_063263559.1 → XP_063119629.1 ATPase family AAA domain-containing protein 2 isoform X3
XM_039079210.2 → XP_038935138.1 ATPase family AAA domain-containing protein 2 isoform X4

UniProtKB/TrEMBL

A0A8I5ZVR6

Conserved Domains (3) summary

cd05528
Location:547 → 657

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

COG0464
Location:5 → 494

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

cl38936
Location:1 → 156

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039079209.2 → XP_038935137.1 ATPase family AAA domain-containing protein 2 isoform X2

UniProtKB/TrEMBL

A0A8I5ZVR6

Related

ENSRNOP00000081791.2, ENSRNOT00000117872.2

Conserved Domains (3) summary

cd05528
Location:643 → 753

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

COG0464
Location:101 → 590

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

cd19517
Location:83 → 252

RecA-like_Yta7-like; ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains