Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pkmyt1provided by RGD
Official Full Name: protein kinase, membrane associated tyrosine/threonine 1provided by RGD
Primary source: RGD:1305434
See related: EnsemblRapid:ENSRNOG00000003657 AllianceGenome:RGD:1305434
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305434
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in meiotic cell cycle; negative regulation of G2/M transition of mitotic cell cycle; and negative regulation of G2/MI transition of meiotic cell cycle. Predicted to be located in Golgi apparatus; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 44.4), Thymus (RPKM 39.7) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (13252805..13263584)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (12748221..12758995)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (13061077..13072277)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G2/MI transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

NP_001099236.1

EC 2.7.11.1

XP_017452548.1

EC 2.7.11.1

XP_063124618.1

EC 2.7.11.1

XP_063124619.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105766.1 → NP_001099236.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

See identical proteins and their annotated locations for NP_001099236.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A6HCL6, B5DFC5, G3V6G8

Conserved Domains (2) summary

smart00220
Location:101 → 350

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14050
Location:99 → 348

PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

13252805..13263584

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597059.3 → XP_017452548.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

UniProtKB/TrEMBL

A6HCL6, B5DFC5, G3V6G8

Related

ENSRNOP00000004936.4, ENSRNOT00000004936.8

Conserved Domains (2) summary

smart00220
Location:101 → 350

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14050
Location:99 → 348

PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
XM_063268549.1 → XP_063124619.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2
XM_063268548.1 → XP_063124618.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2