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    Ly49i2 Ly49 inhibitory receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 260324, updated on 9-Dec-2024

    Summary

    Symbol
    Ly49i2provided by RGD
    Full Name
    Ly49 inhibitory receptor 2provided by RGD
    Primary source
    RGD:628669
    See related
    EnsemblRapid:ENSRNOG00000069072 AllianceGenome:RGD:628669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signaling receptor activity. Involved in negative regulation of signal transduction. Predicted to be located in plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 8.7), Testes (RPKM 5.3) and 4 other tissues See more
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    Genomic context

    See Ly49i2 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (166156061..166206865, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (164470840..164495461, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (164876252..164901832, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene Ly49 inhibitory receptor 3 Neighboring gene killer cell lectin-like receptor 4 Neighboring gene uncharacterized LOC134486850 Neighboring gene killer cell lectin-like receptor, subfamily A, member 4, pseudogene 1 Neighboring gene killer cell lectin-like receptor, subfamily A, member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Ly49 inhibitory receptor 2; ly49 inhibitory receptor 2
    Names
    killer cell lectin-like receptor 5-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152848.2NP_690061.2  Ly49 inhibitory receptor 2

      Status: VALIDATED

      Source sequence(s)
      AY115572, JAXUCZ010000004
      UniProtKB/TrEMBL
      Q8K3G1
      Related
      ENSRNOP00000068787.3, ENSRNOT00000078690.3
      Conserved Domains (1) summary
      cd03593
      Location:145260
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      166156061..166206865 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285636.1XP_063141706.1  ly49 inhibitory receptor 2 isoform X2

      UniProtKB/TrEMBL
      A6IM89
    2. XM_063285635.1XP_063141705.1  ly49 inhibitory receptor 2 isoform X1