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    Spopl speckle type BTB/POZ protein like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296532, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spoplprovided by RGD
    Official Full Name
    speckle type BTB/POZ protein likeprovided by RGD
    Primary source
    RGD:1305847
    See related
    EnsemblRapid:ENSRNOG00000005070 AllianceGenome:RGD:1305847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305847
    Summary
    Predicted to enable identical protein binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of proteolysis. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SPOPL (speckle type BTB/POZ protein like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 216.8), Lung (RPKM 188.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spopl in Genome Data Viewer
    Location:
    3p13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (26478535..26552344, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (6074681..6148508, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (397834..471651, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein L, pseudogene 2 Neighboring gene neurexophilin 2 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 21 Neighboring gene ecdysoneless cell cycle regulator, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase. Errington WJ, et al. Structure, 2012 Jul 3. PMID 22632832
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    speckle-type POZ protein-like
    Names
    speckle-type POZ protein-like A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134447.2 → NP_001127919.1  speckle-type POZ protein-like isoform b

      See identical proteins and their annotated locations for NP_001127919.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5Y679, B2RZC7, F7FKB4
      Related
      ENSRNOP00000035106.4, ENSRNOT00000033653.6
      Conserved Domains (3) summary
      cd18519
      Location:297 → 392
      BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
      cl02446
      Location:28 → 166
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl38908
      Location:179 → 301
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    2. NM_001431570.1 → NP_001418499.1  speckle-type POZ protein-like isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2KB38, A0A8I5Y679

    3. NM_001431571.1 → NP_001418500.1  speckle-type POZ protein-like isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5Y679, B2RZC7, F7FKB4

    RNA

    1. NR_197235.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      26478535..26552344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591625.3 → XP_017447114.1  speckle-type POZ protein-like isoform X1

      Related
      ENSRNOP00000075640.1, ENSRNOT00000081816.3
      Conserved Domains (3) summary
      cd18519
      Location:329 → 424
      BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
      cl02446
      Location:28 → 160
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl38908
      Location:211 → 333
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    2. XM_063283453.1 → XP_063139523.1  speckle-type POZ protein-like isoform X1

      UniProtKB/TrEMBL
      A0A0G2KB38, A0A8I5Y679

    3. XM_017591627.3 → XP_017447116.1  speckle-type POZ protein-like isoform X2

      Conserved Domains (3) summary
      cd18519
      Location:297 → 392
      BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
      cl02446
      Location:28 → 166
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl38908
      Location:179 → 301
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    4. XM_039104707.2 → XP_038960635.1  speckle-type POZ protein-like isoform X1

      UniProtKB/TrEMBL
      A0A0G2KB38, A0A8I5Y679
      Conserved Domains (3) summary
      cd18519
      Location:329 → 424
      BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
      cl02446
      Location:28 → 160
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl38908
      Location:211 → 333
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    5. XM_017591626.3 → XP_017447115.1  speckle-type POZ protein-like isoform X1

      UniProtKB/TrEMBL
      A0A0G2KB38, A0A8I5Y679
      Conserved Domains (3) summary
      cd18519
      Location:329 → 424
      BACK_SPOPL; BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL)
      cl02446
      Location:28 → 160
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl38908
      Location:211 → 333
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    RNA

    1. XR_005501835.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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