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    Gstm5 glutathione S-transferase, mu 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64352, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gstm5provided by RGD
    Official Full Name
    glutathione S-transferase, mu 5provided by RGD
    Primary source
    RGD:61964
    See related
    EnsemblRapid:ENSRNOG00000049743 AllianceGenome:RGD:61964
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gstm3
    Summary
    Enables glutathione transferase activity and identical protein binding activity. Predicted to be involved in several processes, including cellular detoxification of nitrogen compound; glutathione metabolic process; and response to estrogen. Predicted to be located in cytosol; intercellular bridge; and sperm fibrous sheath. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; cystic fibrosis; larynx cancer; multiple sclerosis; and osteosarcoma. Orthologous to human GSTM3 (glutathione S-transferase mu 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 3680.8), Brain (RPKM 397.5) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Gstm5 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (198219769..198222732)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (195531599..195534562)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) Unplaced Scaffold NW_007906853.1 (53050..55845)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550122 Neighboring gene EPS8 like 3 Neighboring gene glutathione S-transferase, mu 5-like Neighboring gene uncharacterized LOC120100916 Neighboring gene glutathione S-transferase, mu 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis of peripheral T-lymphocytes in patients with asthma. Jeong HC, et al. Chest, 2007 Aug. PMID 17550934
    2. Expression profiling identifies genes involved in emphysema severity. Francis SM, et al. Respir Res, 2009 Sep 2. PMID 19723343, Free PMC Article
    3. Glutathione S-transferase GSTM3 and GSTP1 genotypes and larynx cancer risk. Jourenkova-Mironova N, et al. Cancer Epidemiol Biomarkers Prev, 1999 Feb. PMID 10067818
    4. Multiple glutathione S-transferase isoforms are present on male germ cell plasma membrane. Rao AV, et al. FEBS Lett, 2001 Oct 26. PMID 11684093
    5. Glutathione S-transferase hGSTM3 and ageing-associated neurodegeneration: relationship to Alzheimer's disease. Tchaikovskaya T, et al. Mech Ageing Dev, 2005 Feb. PMID 15621212

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular detoxification of nitrogen compound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutathione metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nitrobenzene metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to estrogen ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm fibrous sheath ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase Mu 5
    Names
    GST class-mu 5
    glutathione S-transferase mu 3
    NP_742035.1
    XP_038958976.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172038.2 → NP_742035.1  glutathione S-transferase Mu 5

      See identical proteins and their annotated locations for NP_742035.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q9Z1B2
      UniProtKB/TrEMBL
      A0A8L2R3A5, A6HUV7
      Related
      ENSRNOP00000065389.1, ENSRNOT00000072342.4
      Conserved Domains (2) summary
      cd03209
      Location:96 → 216
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:7 → 88
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      198219769..198222732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103048.2 → XP_038958976.1  glutathione S-transferase Mu 5 isoform X1

      UniProtKB/TrEMBL
      A6HUV8
      Conserved Domains (2) summary
      cd03209
      Location:56 → 176
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cl00388
      Location:24 → 48
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1B2.3 GenPept UniProtKB/Swiss-Prot:Q9Z1B2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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